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National Collaborating Centre for Chronic Conditions (UK). Parkinson's Disease: National Clinical Guideline for Diagnosis and Management in Primary and Secondary Care. London: Royal College of Physicians (UK); 2006. (NICE Clinical Guidelines, No. 35.)

Appendix BDetails of questions and literature searches

Table B1Details of questions and literature searches

Question IDQuestion wordingStudy type filters usedDatabase and year
DIAG1How effective is clinical expert diagnosis (using UK PDS Brain Bank Criteria) vs non-expert diagnosis in diagnosing patients with Parkinson’s disease?DiagnosisMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
DIAG2How effective is clinical expert diagnosis (using UK PDS Brain Bank Criteria) vs the post-mortem gold standard in diagnosing patients with Parkinson’s disease?DiagnosisMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
DIAG3How effective is acute levodopa testing and apomorphine testing vs long-term clinical follow-up in determining an accurate diagnosis in patients with a parkinsonian syndrome?DiagnosisMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
DIAG4aHow effective is magnetic resonance imaging vs long-term clinical follow-up in determining an accurate diagnosis in patients with a parkinsonian syndrome?DiagnosisMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
DIAG4bHow effective is magnetic resonance volumetry vs long-term clinical follow-up in determining an accurate diagnosis in patients with a parkinsonian syndrome?DiagnosisMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
DIAG4cHow effective is magnetic resonance spectroscopy vs long-term clinical follow-up in determining an accurate diagnosis in patients with a parkinsonian syndrome?DiagnosisMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
DIAG6How effective is positron emission tomography vs long-term clinical follow-up in determining an accurate diagnosis in patients with a parkinsonian syndrome?DiagnosisMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
DIAG7How effective is single photon emission computed tomography vs long-term clinical follow-up in determining an accurate diagnosis in patients with a parkinsonian syndrome?
* Redone to include differential diagnosis of PD.
DiagnosisMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
DIAG8How effective is objective smell testing vs long-term clinical follow-up in determining an accurate diagnosis in patients with suspected Parkinson’s disease?All study typesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
MON1What is the most appropriate frequency of follow-up after the initial diagnosis of Parkinson’s disease?All study typesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
COMM1What approach to patient engagement best aids patient understanding on diagnosis of Parkinson’s disease?All study types including qualitativeMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
BNI 1985–2005
PsycInfo 1887–2005
TxNP1Is MAO-B vs placebo or levodopa effective in reducing the rate of progression of early Parkinson’s disease?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
TxNP2Are dopamine agonists vs placebo or levodopa effective in reducing the rate of progression of early Parkinson’s disease?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
TxNP3Is co-enzyme Q10 vs placebo or levodopa effective in reducing the rate of progression of early Parkinson’s disease?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
AMED 1985–2005
TxNP4Are specific vitamins vs placebo or levodopa effective in reducing the rate of progression of early Parkinson’s disease?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
AMED 1985–2005
TxMN1What is the effectiveness of MAO-B vs placebo or levodopa in the treatment of early Parkinson’s disease?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
TxMN2What is the effectiveness of dopamine-agonists vs placebo or levodopa in the treatment of functionally disabled early Parkinson’s disease?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
TxMN3What is the effectiveness of amantadine vs placebo or levodopa in the treatment of functionally disabled early Parkinson’s disease?Systematic reviews, RCTs and comparative studiesMedline 2000–2005
Embase 2000–2005
*Cochrane 2000–2005
CINAHL 2000–2005
*Cochrane search update only
TxMN4What is the effectiveness of MAO-B vs dopamine agonists in the treatment of early Parkinson’s disease?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
TxMN5What is the effectiveness of immediate-release levodopa vs placebo in the treatment of functionally disabled early Parkinson’s disease?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
TxMN6What is the effectiveness of modified-release levodopa vs immediate-release levodopa in the treatment of early Parkinson’s disease?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
TxMN9What is the effectiveness of anticholinergics vs placebo in the treatment of functionally disabled early Parkinson’s disease?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
TxMN10What is the effectiveness of beta-blockers vs placebo in the treatment of functionally disabled early Parkinson’s disease?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
TxCM1What is the effectiveness of adding MAO-B vs placebo in the treatment of later Parkinson’s disease patients with motor complications?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
TxCM2What is the effectiveness of adding dopamine- agonists vs placebo in the treatment of later Parkinson’s disease patients with motor complications?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
TxCM3What is the effectiveness of adding amantadine vs placebo in the treatment of later Parkinson’s disease patients with motor complications?Systematic reviews, RCTs and comparative studiesMedline 2000–2005
Embase 2000–2005
*Cochrane 2000–2005
CINAHL 2000–2005
*Cochrane search update only
TxCM4What is the effectiveness of adding dopamine agonists vs MAOB inhibitors in the treatment of later Parkinson’s disease patients with motor complications?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
TxCM5What is the effectiveness of adding dopamine-agonists vs amantadine in the treatment of later Parkinson’s disease patients with motor complications?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
TxCM6What is the effectiveness of adding dopamine-agonists vs COMT inhibitors in the treatment of later Parkinson’s disease patients with motor complications?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
TxCM7What is the effectiveness of adding COMT inhibitors vs placebo in the treatment of later Parkinson’s disease patients with motor complications?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
TxCM8What is the effect of controlled-release levodopa vs immediate-release levodopa in the treatment of later Parkinson’s disease?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
TxCM9What is the effectiveness of apomorphine vs standard oral treatment in later Parkinson’s disease?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
SURG1What is the effectiveness and safety of any deep brain stimulation procedure vs standard medical therapy in the treatment of motor fluctuations and complications in patients with Parkinson’s disease?All study typesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
SURG2Which is the most effective form of deep brain stimulation in the treatment of motor fluctuations and complications in patients with Parkinson’s disease?All study typesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
AHP1What is the effectiveness of physiotherapy vs standard medical therapy or placebo in the treatment of Parkinson’s disease?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
AMED 1985– 2005
AHP2What is the effectiveness of speech and language therapy vs standard medical therapy or placebo in the treatment of speech disturbance in Parkinson’s disease?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
AMED 1985–2005
AHP3What is the effectiveness of occupational therapy vs standard medical therapy or placebo in the treatment of Parkinson’s disease?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
AMED 1985–2005
AHP4What is the effectiveness of Parkinson’s disease nursing specialist care vs standard care or placebo in the treatment of Parkinson’s disease?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
AMED 1985–2005
BNI 1985–2005
PSYC1What is the effectiveness of antidepressant therapies vs placebo or active comparator in the treatment of depression in Parkinson’s disease?Systematic reviews, RCTs and comparative studiesMedline 2001–2005
Embase 2001–2005
*Cochrane 2001–2005
CINAHL 2001–2005
PsycINFO 2001–2005
*Cochrane search update only
PSYC2What is the effectiveness of atypical antipsychotic therapies vs placebo or active comparator in the treatment of psychosis in patients with Parkinson’s disease?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
PsycINFO 1887–2005
PSYC3Is cognitive enhancement therapy effective in dementia in Parkinson’s disease and Lewy body dementia?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
CINAHL 1982–2005
PsycINFO 1887–2005

Note: The final cut-off date for all searches was 28 February 2005.

Copyright © 2006, Royal College of Physicians of London.

All rights reserved. No part of this publication may be reproduced in any form (including photocopying or storing it in any medium by electronic means and whether or not transiently or incidentally to some other use of this publication) without the written permission of the copyright owner. Applications for the copyright owner’s written permission to reproduce any part of this publication should be addressed to the publisher.

Cover of Parkinson's Disease
Parkinson's Disease: National Clinical Guideline for Diagnosis and Management in Primary and Secondary Care.
NICE Clinical Guidelines, No. 35.
National Collaborating Centre for Chronic Conditions (UK).

NICE (National Institute for Health and Care Excellence)

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