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Drug Class Review: Nasal Corticosteroids: Final Report Update 1 [Internet]

Drug Class Review: Nasal Corticosteroids: Final Report Update 1 [Internet]

Drug Class Reviews - Oregon Health & Science University

Version: June 2008

Summary

Table 15 summarizes the main findings of this review.

Results

We identified 1,404 (Update 1: 282) articles from literature searches and reviews of reference lists. This includes citations from dossiers submitted by the manufacturers of mometasone, fluticasone, and budesonide (Update 1: budesonide aqueous, fluticasone furoate, mometasone furoate, and triamcinolone acetonide.) After applying the eligibility and exclusion criteria to the titles and abstracts, we obtained copies of 489 (Update 1: 77) full-text articles. After re-applying the criteria for inclusion, we ultimately included 84 (Update 1: 29) publications, including 9 from submitted dossiers. The results of our literature search are detailed in Appendix C.

Introduction

Allergic rhinitis is a condition characterized by sneezing, watery rhinorrhea, nasal itching, congestion, itchy palate, and itchy, red, and watery eyes. The prevalence of allergic rhinitis has increased significantly over the last 15 years and the disease currently affects twenty to forty million Americans. It is estimated that in 2002, approximately 14 million medical office visits were attributed to allergic rhinitis. Many suffering from allergic rhinitis are children and young adults, whom, if treated early, may avoid later stage complications. If left untreated, this condition could lead to the development or worsening of comorbidities including chronic or recurrent sinusitis, asthma, otitis media, an respiratory infections., Moderate to severe allergic rhinitis may also lead to sleep disorders, fatigue, and learning problems.,

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