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Peterson K, McDonagh M, Carson S, et al. Drug Class Review: Newer Antiemetics: Final Report Update 1 [Internet]. Portland (OR): Oregon Health & Science University; 2009 Jan.

Appendix B. US Food and Drug Administration recommendations for pediatric dosages

I. Prevention of emesis following chemotherapy with moderate to high emetic risk

Drug (brand name)FormAge rangeDosageb
Aprepitant/fosaprepitant (Emend®)Injection/CapsuleN/ANot established
Dolasetron (Anzemet®)Injection, Tableta2 to 16 years1.8 mg/kg once (maximum of 100 mg)
Granisetron (Kytril®)Injection2 to 16 years10 mcg/kg once
Tablet, oral solution2 to 16 years2 mg once or 1 mg BID
Ondansetron (Zofran®)Injection6 months to 18 years0.15 mg/kg TID
Tableta, orally disintegrating tableta, oral solutiona4 to 11 years4 mg TID (days 1 to 3)
≥ 12 years8 mg BID (days 1 to 3)
Palonosetron (Aloxi®)Injection, tabletN/ANot established

Abbreviations: BID, twice daily; IV, intravenous; N/A, not applicable; TID, three times daily.

a

Moderate emetic risk only.

b

Administered prior to chemotherapy, unless otherwise specified.

II. Prevention of postoperative emesis

Drug (Brand Name)FormAge rangeDosagea
Aprepitant/fosaprepitant (Emend®)Injection/CapsuleN/ANot established
Dolasetron (Anzemet®)Injection (prevention or treatment)2 to 16 years0.35 mg/kg once (maximum of 12.5 mg)
Tablet2 to 16 years1.2 mg/kg once (maximum of 100 mg)
Granisetron (Kytril®)Injection, tablet, oral solutionN/ANot established
Ondansetron (Zofran®)Injection1 month to 12 years0.1 mg/kg once (for weight of 40 kg or less); 4 mg once (for weight above 40 kg)
Tablet, orally disintegrating tablet, oral solutionN/ANot established
Palonosetron (Aloxi®)Injection, tabletN/ANot established

Abbreviations: BID, twice daily; IV, intravenous; N/A, not applicable; TID, three times daily.

a

Administered before postoperative procedure or before cessation of anesthesia.

Moderate emetic risk only.

Administered prior to chemotherapy, unless otherwise specified.

Administered before postoperative procedure or before cessation of anesthesia.

Copyright © 2008, Oregon Health & Science University, Portland, Oregon.
Cover of Drug Class Review: Newer Antiemetics
Drug Class Review: Newer Antiemetics: Final Report Update 1 [Internet].
Peterson K, McDonagh M, Carson S, et al.
Portland (OR): Oregon Health & Science University; 2009 Jan.

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