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Diagnosed coronary heart disease (including post-myocardial infarction)


The renin-angiotensin system is a complex biologic system between the heart, brain, blood vessels, and kidneys that leads to the production of biologically active agents, including angiotensin I and II and aldosterone, which act together to impact a variety of bodily functions including blood vessel tone, sodium balance, and glomerular filtration pressure. The multiple and varied effects of these agents allows the renin-angiotensin system to play a wide role in the pathology of hypertension, cardiovascular health, and renal function.


Literature searches identified 1328 citations. We received dossiers from the manufacturers of aliskiren, irbesartan, olmesartan, telmisartan, and valsartan. The results of the study selection process are outlined in Figure 1. See Appendix D for the list of studies that were excluded at the full-text level and the reasons for their exclusion.

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