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17.1Health of children born as a result of assisted reproduction

StudyPopulationOutcomesResultsCommentsStudy typeEL
Tanbo et al. 2003113330 studies (13 cohort; 17 case studies)Birth defectsNon-significant difference:

RR 1.13 (CI 1.00 to 1.29)
Conclusions uncertain in these outcomes: chromosomal abnormalities, neurological and growth disturbances due to small number of accepted studiesSR2b–3
Ludwig 20021128ICSI infants (n = 3372)

Population-based control (n = 30,940)
Major malformation rateSignificant difference:

ICSI infants: 291/3372 (8.6%)
Population-based control: 2140/30940 (6.9%)
Major malformations defined by the EUROCAT:
International Clearinghouse of Birth Defects Monitoring Systems, 1999)
OB3
Klip et al. 20011137IVF children (n = 9484)

Naturally conceived children (n = 7532) (mothers diagnosed with subfertility)
Cancer incidenceNo significant difference:

16 cancers observed in both groups versus
15.5 expected: SIR 1.0 (CI 0.6 to 1.7)

IVF versus naturally conceived children: RR 0.8 (CI 0.3 to 2.3
6 years of follow-upOB3
Golombok et al. 19951141184 families with a child conceived by IVF and donor insemination (n = 86) and a child conceived naturally or adopted (n = 98)

Children aged 4–8 years
Separation Anxiety Test

Family Relations Test

Pictorial Scale of Perceived Competence and Social Acceptance
No significant differencesExclusion criteria: children with congenital abnormality, brain damage and result of multiple birthOB3
Montgomery et al. 19991142743 IVF children aged > 4 years compared with normative sample used for establishing the Achenbach behavioural questionnairesThought problems

Internalising problems

Externalising problems

Attention problems

Social problems
No significant differencesSV3

From: Evidence tables

Cover of Fertility
Fertility: Assessment and Treatment for People with Fertility Problems.
NICE Clinical Guidelines, No. 11.
National Collaborating Centre for Women's and Children's Health (UK).
London (UK): RCOG Press; 2004 Feb.
Copyright © 2004, National Collaborating Centre for Women’s and Children’s Health.

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