Table 173DCRT vs. 2DRT: Summary of study design, quality, and key outcomes

SiteStudiesnRCTProspective ObservationalAssessor BlindedGroups ComparableTreatments in same time periodWell-done multivariable analysis/intention- to-treatUSPSTF Good/Fair
NPC33701100100/0
OPH11300000000/0
PNS22310000000/0
UNP1870000000/0
LAR11220000000/0
MIX45570201200/0
Total1214971301300/0
OutcomeTotal No. studiesLarge (> 15 pctg pts) 3DCRT-2DRT differenceModerate (6–15 pctg pts) 3DCRT-2DRT differenceSmall (0–5 pctg pts) 3DCRT-2DRT differenceUnquantifiable 3DCRT-2DRT difference
No. StudiesSigNSP NRNo. StudiesSigNSp NRNo. StudiesSigNSp NRNo. StudiesSigNSp NR
Acute xerostomia111?
Late xerostomia421+1+21+1−
Acute mucositis411+31?1+
1−
Late mucositis221?1+
Acute dysphagia111?
Late dysphagia0
Acute skin toxicity331?2+
Late skin toxicity311+21+
1=
Acute osteoradionecrosis/bone toxicity0
Late osteoradionecrosis/bone toxicity221−
1=
Tumor control821+1+22+42+
2?
Patient survival711+22+41+
1−
2?

+: favors IMRT; −: favors 3DCRT; ?: unclear which group is favored; =: same result for both groups

Statistical significance is based on multivariable analyses, where available; if only univariate results are reported, those are used.

From: Results

Cover of Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer
Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer [Internet].
Comparative Effectiveness Reviews, No. 20.
Samson DJ, Ratko TA, Rothenberg BM, et al.

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