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Table 3Summary of disease-specific quality-of-life instruments and symptom-specific instruments used in abstracted articles

InstrumentArticles Using InstrumentDomains Covered, # itemsScoringTest- Retest ReliabilityInternal ConsistencyConstruct ValidityCriterion ValidityResponsiveness to Change over Time
Generic and Global Quality of Life
Short Form 36 (SF-36)Pow et al. 2006[28]; McMillan et al. 2006[29]Physical: Physical functioning, 10 Limitations of role functioning from physical limitations, 4 Bodily pain, 2 General perception of health, 5

Mental health: Vitality, 4 Role limitations from emotional problems, 3 Social functioning, 2 Mental health, 5

Self-reported health transition, 1
Two composite scores from 0 to 100 for physical and for mental health; higher scores= better functioningYesYesYesYesYes
Disease-Specific Quality of Life
Head and Neck Cancer- Specific Quality of Life (HNQOL)Jabbari et al. 2005[30]; Feng et al. 2007[31]Eating, 6
Communication, 4
Pain, 4
Emotion, 4
Lower scores= lower QOLYesYesYesUncertainYes
European Organization for Research and Treatment of Cancer QLQ- C30 (EORTC QLQ-C30)Pow et al. 2006[28]; Fang et al. 2007[32]; McMillan et al. 2006[29]; Fang et al. 2008[33]; Vergeer et al. 2008[34]Functioning
--Physical, 5
--Role, 2
--Emotional, 4
--Cognitive, 2
--Social, 2
--Global QOL, 2
Fatigue, 3
Pain, 2
Nausea/vomiting, 2
Dyspnea
Insomnia
Appetite loss
Constipation
Diarrhea
Financial problems
0 to 100; high score=high level of symptoms or high level of functioning or global QOLYesYesYesYesYes
European Organization for Research and Treatment of Cancer QLQ- HN35 (EORTC QLQ-HN35 [1 of 10 modules to accompany EORTC QLQ- C30])Pow et al. 2006[28]; Fang et al. 2007[31]; McMillan et al. 2006[29]; Fang et al. 2008[33]; Vergeer et al. 2008[34]; van Rij et al. 2008[35]Pain, 4
Swallowing, 4
Senses, 2
Speech, 3
Social eating, 4
Social contact, 5
Sexuality, 2
Single items, 11
0 to 100; high score=high level of symptomsYes (Chinese translation)*YesYesYesYes
Head and Neck Cancer Inventory (HNCI)Yao et al. 2007[36]; Dornfeld et al. 2007[37]Speech, eating, aesthetics, social disruption; 30 items0 to 100 for each domain; higher scores represent better outcomesYesYesYesYesYes
University of Washington Quality of Life (UWQOL)Feng et al. 2007[31]; Scrimger et al. 2007[38]Version 4: Domain-specific (pain, appearance, activity level, recreation, swallowing, chewing, speech, shoulder function, taste, saliva function, depression, anxiety), 12

Generic QOL, Free text question, importance ranking
0 (worst) to 100 (best QOL) based on 12 domain- specific questions. Generic QOL reported separatelyYes (Brazilian Portuguese translation)YesYes (Brazilian Portuguese translation)YesYes
Symptom-Specific
Xerostomia questionnaire from #10300 Eisbruch et al. 2001 (XQ)Jabbari et al. 2005[30]; Daly et al. 2007[39]; Pacholke et al. 2005[40]; van Rij et al. 2008[35]Dryness while eating or chewing, 4
Dryness while not eating or chewing, 4
0 to 100; higher scores= greater xerostomiaYesYesYesYesYes
Unnamed xerostomia questionnaire from Johnson et al. 1993Kam et al. 2007[41]6 itemsNo summary score reported; item response= increase ≥25 mm on visual analog scaleNo studies of reliability and validity found.
Unnamed xerostomia questionnaireBraaksma et al. 2003[42]3 yes/no questions and visual analog scale, all re: dry mouthNo summary score reportedNo studies of reliability and validity found.
*

Kappa low for some items, e.g., 0.38 for opening mouth; questionnaires administered 2 weeks apart.

Sources: 36,43–63

Kappa low for some items, e.g., 0.38 for opening mouth; questionnaires administered 2 weeks apart.

From: Methods

Cover of Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer
Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer [Internet].
Comparative Effectiveness Reviews, No. 20.
Samson DJ, Ratko TA, Rothenberg BM, et al.

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