ParametersRated as NO limitationRated as SERIOUS limitationRated as VERY SERIOUS limitation
Limitation in designNegligible limitationThis may downgrade the quality of evidence by 1 levelThis may downgrade the quality of evidence by 2 levels
Inconsistency
Indirectness
Imprecision
Publication bias

From: Appendix H, GRADE Tables, Assessing the Evidence

Cover of Comparative Effectiveness of Lipid-Modifying Agents
Comparative Effectiveness of Lipid-Modifying Agents [Internet].
Comparative Effectiveness Reviews, No. 16.
Sharma M, Ansari MT, Soares-Weiser K, et al.

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