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Table 8Population Characteristics of Studies Measuring Serum LH/FSH Levels in Men with Erectile Dysfunction

Study Details8Study DesignSettingED ScaleAgeComorbiditySerum LevelsTest timeCut-off (LH/FSH)Normal Range
(LH/FSH)
Assay
Mean(SD)Range
Jaffe 1996 (Israel)Prospectiveclinic-55.3HypertensionTT, BT, PRL, LH, FSHMorningLH: >15 mIU/mL; FSH: NRNREIA
Earle 2003 (Australia)ProspectiveDepartment of Endocrinology and DiabetesNR54.916–82Prostate cancer, secondary hypogonadismTT, PRL, LH, FSHNR>10U/LLH: 2–9 U/LRIA
Bunch 2002 (USA)RetrospectiveoutpatientsNR64.6 ± 10.851–85DM, IHD, hypertension, hyperlipidemia, depression, sleep apnea, CVA, AF, hypothyroidism, prostate cancer, CRF, head tumors, compression fracturesTT, LHNRLH: <13nIU/mlNRRIA
Fahmy 1999 (UK)ProspectiveED clinicsexual activity questionneireNRNRNRTT, FSH,
PRL
morning (9–11 am)NRNRNR
Akpunonu 1994 (USA)ProspectivePrimary care clinicNR55.4±1024–76Renal failure, DMTT, PRL, LH, FSHNRNRLH: 5–20 IU/L; FSH: 5–20 IU/LNR
Johnson 1992 (USA)ProspectiveUrology clinicNRNRNRTT, PRL, LHNRNRNRNR
El-Sakka 2005 (Egypt) Prospective Andrology clinic IIEF Endocrinopathy (297) -51.9 ± 12.2
No endocrinopathy (951) -52.3 ± 11.7
Obesity, diabetes, hypertension,
ischemic heart disease, dyslipidemia, cerebrovasular stroke
TT, PRL, LH, FSH NR LH <1.3 mIU/mL; FSH <0.9 mIU/mL NR ECLA
Guay 1991 (USA)ProspectiveEndocrinology clinic-53.2 ± 9.1NRTT, LH, FSHMorningNRLH: 2–20 mIU/L; FSH: 2–10 mIU/LRIA
Low 2006 (MalaysiaProspectiveCommunityIIEF-559.3 ± 7.38DepressioncFT, TT, PRL, LHMorning (before 11am)>12 IU/lNRdirect CMI
8

Baseline serum levels: T = total testosterone; Pr = prolactin; LH = luteinizing hormone; FSH = follicle-stimulating hormone SD = standard deviation; n = number of events; N = total number of participants; % = prevalence

Assay: chemiluminescent microparticle immunoassay (CMI); electrochemiluminescence immunoassay (ECLA), radioimunoassay (RIA), enzyme immunoassay (EIA)

8

calculated free testosterone; the cut for LH > 15mIU/ml was used to define primary hypogonadism

Scales: Sex Health Inventory for Men (SHIM); sexual functioning questionnaire (SFQ);

From: 3, Results

Cover of Diagnosis and Treatment of Erectile Dysfunction
Diagnosis and Treatment of Erectile Dysfunction.
Evidence Reports/Technology Assessments, No. 171.
Tsertsvadze A, Yazdi F, Fink HA, et al.

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