Table 22Ovarian stimulation - gonadotropin dosing regimens

StudyInterventionNEfficacy
Clinical Pregnancy Ongoing Pregnancy/Live Birth
Rel EffLower 95% CIUpper 95% CIRel EffLower 95% CIUpper 95% CI
Aboulghar et al., 2004190Reference Standard dose gonadotropins 72
↑ by 75 IU from time of GnRH antagonist 79 1.15 0.74 1.79 - - -
GnRH antagonistMultiples 0.97 (0.49, 1.93)
Klinkert et al., 2005191Reference 150 IU rFSH 26
300 IU rFSH 26 0.30 0.04 3.00 0.50 0.05 5.18
Low antral follicle count
Out et al., 2004192Reference 150 IU rFSH 132
200 IU rFSH132---0.780.531.16
Popovic-Todorovic et al., 2003166Reference Standard step-up FSH 131
Individualized dose based on nomogram1311.501.032.18---
Hoomans et al., 2002193 and Ng et al., 2000194Reference 200 IU rFSH 166
100 IU rFSH1631.120.721.751.100.671.81
Latin-American Puregon IVF Study Group, 2001195Reference 150 IU rFSH 201
250 IU rFSH2030.990.641.53---
Hugues et al., 2003196Reference rFSH dose prepared by bioassay 65
rFSH dose prepared by mass661.160.672.01---
Propst et al., 2006197Reference Constant dose rFSH 30
Step-up protocol300.860.591.251.060.691.62
Scholtes et al., 2004198Reference 150 IU rFSH daily 51
450 IU rFSH every 3 days511.860.814.270.830.272.56

From: 3, Results

Cover of Effectiveness of Assisted Reproductive Technology
Effectiveness of Assisted Reproductive Technology.
Evidence Reports/Technology Assessments, No. 167.
Myers ER, McCrory DC, Mills AA, et al.

PubMed Health. A service of the National Library of Medicine, National Institutes of Health.