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Table 25Impact of tumor grade on the effectiveness of lumpectomy plus radiation vs. lumpectomy alone

TreatmentAuthor, YearNumber of WomenEstimate/DesignMonths of FollowupTumor GradeRelative Measure of the Association (95% CI)
Distant Recurrence
LR vs. LBijker, 2001357284RR/Randomized control trial*64.8Well0.214 (0.0104; 4.428)
LR vs. LBijker, 2001357198RR/Randomized control trial*64.8Intermediate3 (0.317; 28.348)
LR vs. LBijker, 2001357293RR/Randomized control trial*64.8Poor1.124 (0.4; 3.158)
All-Cause Mortality
LR vs. LBijker, 2001357284RR/Randomized control trial*64.8Well0.536 (0.049; 5.85)
LR vs. LBijker, 2001357198RR/Randomized control trial*64.8Intermediate1 (0.063; 15.765)
LR vs. LBijker, 2001357293RR/Randomized control trial*64.8Poor1.264 (0.462; 3.461)
Local DCIS or Invasive
LR vs. LBijker, 2001357313RR/Randomized control trial*64.8Low0.575 (0.293; 1.128)
LR vs. LBijker, 2001357250RR/Randomized control trial*64.8Moderate0.607 (0.351; 1.052)
LR vs. LBijker, 2001357210RR/Randomized control trial*64.8High0.648 (0.389; 1.08)
LR vs. LFisher, 1999295321RR/Randomized control trial*102Good0.416 (0.255; 0.677)
LR vs. LFisher, 1999295302RR/Randomized control trial*102Poor0.444 (0.287; 0.685)
LR vs. LNeuschatz, 2001339109OR/Observational studies60Low0.455 (0.007; 30.173)
LR vs. LNeuschatz, 2001339109OR/Observational studies60High0.629 (0.166; 2.38)

Bold = statistically significant

*

Multivariate adjusted

Multivariate adjusted

From: 3, Results

Cover of Diagnosis and Management of Ductal Carcinoma in Situ (DCIS)
Diagnosis and Management of Ductal Carcinoma in Situ (DCIS).
Evidence Reports/Technology Assessments, No. 185.
Virnig BA, Shamliyan T, Tuttle TM, et al.

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