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Table 78Zotepine vs. FGA (Analysis of side effects)

Outcome or SubgroupkTotal NStatistical MethodEffect [95% CI]
8.1 Leaving the study early: 3. Due to adverse event (medium-term)1125RR (M-H, Fixed, 95% CI)1.32 [0.76, 2.26]
 8.1.1 vs HAL1125RR (M-H, Fixed, 95% CI)1.32 [0.76, 2.26]
8.2 AE: 1. Metabolic side effects - Weight change from baseline (kg) (medium-term)1125MD (IV, Fixed, 95% CI)Not estimable
 8.2.1 vs HAL1125MD (IV, Fixed, 95% CI)Not estimable
8.3 AE: 1. Metabolic side effects - Weight change (kg) (short-term)1105MD (IV, Fixed, 95% CI)−1.30 [−6.26, 3.66]
 8.3.1 vs HAL00MD (IV, Fixed, 95% CI)Not estimable
 8.3.2 vs other FGA1105MD (IV, Fixed, 95% CI)−1.30 [−6.26, 3.66]
8.4 AE: 2. Neurologic side effects - Use of anticholinergic medication (short-term)3221RR (M-H, Random, 95% CI)0.66 [0.56, 0.78]
 8.4.1 vs HAL3221RR (M-H, Random, 95% CI)0.66 [0.56, 0.78]
8.5 AE: 2. Neurologic side effects - Movement disorders (treatment-emergent) (short- term)5RR (M-H, Fixed, 95% CI)Subtotals only
 8.5.1 vs HAL: any extrapyramidal event1125RR (M-H, Fixed, 95% CI)0.28 [0.08, 0.94]
 8.5.3 vs HAL: tremor4324RR (M-H, Fixed, 95% CI)0.60 [0.39, 0.94]
 8.5.5 vs HAL: akathisia3196RR (M-H, Fixed, 95% CI)0.65 [0.48, 0.88]
 8.5.7 vs HAL: asthenia1125RR (M-H, Fixed, 95% CI)1.68 [0.50, 5.66]
 8.5.10 vs HAL: dystonia270RR (M-H, Fixed, 95% CI)0.47 [0.24, 0.93]
 8.5.12 vs HAL: dyskinesia2251RR (M-H, Fixed, 95% CI)0.77 [0.54, 1.10]
 8.5.13 vs HAL: rigidity270RR (M-H, Fixed, 95% CI)0.50 [0.30, 0.83]

From: 10, Clinical evidence summary tables

Cover of Schizophrenia
Schizophrenia: Core Interventions in the Treatment and Management of Schizophrenia in Primary and Secondary Care (Update) [Internet].
NICE Clinical Guidelines, No. 82.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2009 Mar.
Copyright © 2009, National Collaborating Centre for Mental Health.

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