Table 77Sertindole vs. FGA (Analysis of side effects)

Outcome or SubgroupkTotal NStatistical MethodEffect [95% CI]
7.1 Leaving the study early: 3: Adverse event (short-term)21195RR (M-H, Fixed, 95% CI)2.26 [1.52, 3.36]
 7.1.1 sertindole 8mg vs HAL1245RR (M-H, Fixed, 95% CI)17.70 [1.03, 303.37]
 7.1.2 sertindole 16mg vs HAL1252RR (M-H, Fixed, 95% CI)22.64 [1.35, 380.11]
 7.1.3 sertindole 20mg vs HAL1253RR (M-H, Fixed, 95% CI)12.70 [0.72, 223.04]
 7.1.4 sertindole 24mg vs HAL2445RR (M-H, Fixed, 95% CI)1.44 [0.94, 2.20]
7.2 AE: 2. Neurologic side effects - Akathisia (short-term)1RR (M-H, Fixed, 95% CI)Subtotals only
 7.2.1 sertindole 8mg vs HAL1245RR (M-H, Fixed, 95% CI)0.17 [0.06, 0.46]
 7.2.2 sertindole 16mg vs HAL1252RR (M-H, Fixed, 95% CI)0.08 [0.02, 0.33]
 7.2.3 sertindole 20mg vs HAL1253RR (M-H, Fixed, 95% CI)0.31 [0.15, 0.67]
 7.2.4 sertindole 24mg vs HAL1242RR (M-H, Fixed, 95% CI)0.34 [0.16, 0.73]
7.3 AE: 2. Neurologic side effects - Asthenia (short-term)1RR (M-H, Fixed, 95% CI)Subtotals only
 7.3.1 sertindole 8mg vs HAL1245RR (M-H, Fixed, 95% CI)0.43 [0.16, 1.19]
 7.3.2 sertindole 16mg vs HAL1252RR (M-H, Fixed, 95% CI)0.57 [0.23, 1.41]
 7.3.3 sertindole 20mg vs HAL1253RR (M-H, Fixed, 95% CI)0.81 [0.36, 1.82]
 7.3.4 sertindole 24mg vs HAL1242RR (M-H, Fixed, 95% CI)0.36 [0.12, 1.07]
7.4 AE: 2. Neurologic side effects - Dystonia (short-term)1RR (M-H, Fixed, 95% CI)Subtotals only
 7.4.1 sertindole 8mg vs HAL1245RR (M-H, Fixed, 95% CI)0.06 [0.00, 1.05]
 7.4.2 sertindole 16mg vs HAL1252RR (M-H, Fixed, 95% CI)0.06 [0.00, 0.99]
 7.4.3 sertindole 20mg vs HAL1253RR (M-H, Fixed, 95% CI)0.37 [0.10, 1.35]
 7.4.4 sertindole 24mg vs HAL1242RR (M-H, Fixed, 95% CI)0.27 [0.06, 1.23]
7.5 AE: 2. Neurologic side effects - Extrapyramidal syndrome (short-term)1RR (M-H, Fixed, 95% CI)Subtotals only
 7.5.1 sertindole 8mg vs HAL1245RR (M-H, Fixed, 95% CI)0.09 [0.01, 0.66]
 7.5.2 sertindole 16mg vs HAL1252RR (M-H, Fixed, 95% CI)0.33 [0.11, 0.99]
 7.5.3 sertindole 20mg vs HAL1253RR (M-H, Fixed, 95% CI)0.24 [0.07, 0.84]
 7.5.4 sertindole 24mg vs HAL1242RR (M-H, Fixed, 95% CI)0.36 [0.12, 1.07]
7.6 AE: 2. Neurologic side effects - Hypertonia (short-term)1RR (M-H, Fixed, 95% CI)Subtotals only
 7.6.1 sertindole 8mg vs HAL1245RR (M-H, Fixed, 95% CI)0.40 [0.15, 1.09]
 7.6.2 sertindole 16mg vs HAL1252RR (M-H, Fixed, 95% CI)0.45 [0.18, 1.16]
 7.6.3 sertindole 20mg vs HAL1253RR (M-H, Fixed, 95% CI)0.68 [0.30, 1.52]
 7.6.4 sertindole 24mg vs HAL1242RR (M-H, Fixed, 95% CI)0.41 [0.15, 1.12]
7.7 AE: 2. Neurologic side effects - Hypokinesia (short-term)1RR (M-H, Fixed, 95% CI)Subtotals only
 7.7.1 sertindole 8mg vs HAL1245RR (M-H, Fixed, 95% CI)0.15 [0.01, 2.85]
 7.7.2 sertindole 16mg vs HAL1252RR (M-H, Fixed, 95% CI)0.66 [0.11, 3.86]
 7.7.3 sertindole 20mg vs HAL1253RR (M-H, Fixed, 95% CI)0.65 [0.11, 3.83]
 7.7.4 sertindole 24mg vs HAL1242RR (M-H, Fixed, 95% CI)2.14 [0.55, 8.35]
7.8 AE: 2. Neurologic side effects - Tremor (short-term)1RR (M-H, Fixed, 95% CI)Subtotals only
 7.8.1 sertindole 8mg vs HAL1245RR (M-H, Fixed, 95% CI)0.30 [0.12, 0.71]
 7.8.2 sertindole 16mg vs HAL1252RR (M-H, Fixed, 95% CI)0.19 [0.07, 0.53]
 7.8.3 sertindole 20mg vs HAL1253RR (M-H, Fixed, 95% CI)0.23 [0.09, 0.60]
 7.8.4 sertindole 24mg vs HAL1242RR (M-H, Fixed, 95% CI)0.25 [0.10, 0.65]

From: 10, Clinical evidence summary tables

Cover of Schizophrenia
Schizophrenia: Core Interventions in the Treatment and Management of Schizophrenia in Primary and Secondary Care (Update) [Internet].
NICE Clinical Guidelines, No. 82.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2009 Mar.
Copyright © 2009, National Collaborating Centre for Mental Health.

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