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Table 114Family intervention vs. any control – subgroup analysis by format

Outcome or SubgroupkTotal NStatsEffect (95% CI)
6.1 Mortality - suicide6342RR (M-H, Fixed, 95% CI)0.72 [0.28, 1.88]
 6.1.1 suicide (single)292RR (M-H, Fixed, 95% CI)0.11 [0.01, 1.92]
 6.1.2 suicide (group)199RR (M-H, Fixed, 95% CI)0.48 [0.07, 3.24]
 6.1.3 suicide (mixed)3151RR (M-H, Fixed, 95% CI)2.37 [0.49, 11.54]
6.2 Service outcomes: 1. Hospital admission (0–12 months into treatment)8RR (M-H, Random, 95% CI)Subtotals only
 6.2.1 1–12 months into treatment (Single)4197RR (M-H, Random, 95% CI)0.46 [0.26, 0.81]
 6.2.2 1–12 months into treatment (Multi)3289RR (M-H, Random, 95% CI)0.58 [0.19, 1.77]
 6.2.3 1–12 months into treatment (Multi -studies with a few individual sessions/queries removed)199RR (M-H, Random, 95% CI)1.30 [0.83, 2.02]
 6.2.4 1–12 months into treatment (Mixed)163RR (M-H, Random, 95% CI)0.39 [0.15, 0.99]
6.3 Service outcomes: 1. Hospital admission (13–24 months into treatment)4RR (M-H, Random, 95% CI)Subtotals only
 6.3.1 13–24 months into treatment (Single)139RR (M-H, Random, 95% CI)0.52 [0.24, 1.12]
 6.3.3 13–24 months into treatment (Multi)197RR (M-H, Random, 95% CI)1.42 [0.61, 3.30]
 6.3.4 13–24 months into treatment (Mixed)2146RR (M-H, Random, 95% CI)0.41 [0.25, 0.68]
6.4 Service outcomes: 1. Hospital admission (at follow up)9RR (M-H, Fixed, 95% CI)Subtotals only
 6.4.1 follow up (up to 2 years) after end of treatment (Single)5322RR (M-H, Fixed, 95% CI)0.87 [0.62, 1.23]
 6.4.2 follow up (up to 2 years) after end of treatment (Multi)4331RR (M-H, Fixed, 95% CI)0.87 [0.64, 1.17]
 6.4.3 follow up (up to 2 years) after end of treatment (Multi - papers with a few individual sessions removed)3234RR (M-H, Fixed, 95% CI)0.96 [0.70, 1.31]
 6.4.4 follow up (up to 2 years) after end of treatment (Mixed)00RR (M-H, Fixed, 95% CI)Not estimable
6.5 Global state: 1. Relapse (1–12 months into treatment)11RR (M-H, Fixed, 95% CI)Subtotals only
 6.5.1 1–12 months into treatment (Single)6355RR (M-H, Fixed, 95% CI)0.54 [0.41, 0.72]
 6.5.2 1–12 months into treatment (Single - Ran (had 2 group sessions) removed)3128RR (M-H, Fixed, 95% CI)0.60 [0.35, 1.02]
 6.5.3 1–12 months into treatment (Multi)159RR (M-H, Fixed, 95% CI)0.59 [0.29, 1.22]
 6.5.4 1–12 months into treatment (Mixed)4255RR (M-H, Fixed, 95% CI)0.56 [0.40, 0.78]
6.6 Global state: 1. Relapse (13–24 months into treatment)3150RR (M-H, Fixed, 95% CI)0.63 [0.46, 0.85]
 6.6.1 13–24 months into treatment (Single)287RR (M-H, Fixed, 95% CI)0.57 [0.38, 0.86]
 6.6.2 13–24 months into treatment (Multi)00RR (M-H, Fixed, 95% CI)Not estimable
 6.6.3 13–24 months into treatment (Mixed)163RR (M-H, Fixed, 95% CI)0.72 [0.46, 1.12]
6.7 Global state: 1. Relapse (at follow up)8RR (M-H, Fixed, 95% CI)Subtotals only
 6.7.1 follow up (4–24 months) after end of treatment (Single)3153RR (M-H, Fixed, 95% CI)0.59 [0.42, 0.83]
 6.7.2 follow up (4–24 months) after end of treatment (Multi)2110RR (M-H, Fixed, 95% CI)0.63 [0.41, 0.97]
 6.7.3 follow up (4–24 months) after end of treatment (Multi - studies with a few ind sessions removed)151RR (M-H, Fixed, 95% CI)0.75 [0.33, 1.70]
 6.7.4 follow up (4–24 months) after end of treatment (Mixed)3192RR (M-H, Fixed, 95% CI)0.74 [0.53, 1.02]
6.8 Treatment acceptability: 1. Leaving the study early for any reason22RR (M-H, Fixed, 95% CI)Subtotals only
 6.8.1 Single8417RR (M-H, Fixed, 95% CI)1.38 [0.82, 2.33]
 6.8.2 Single (studies with a few group sessions removed)7422RR (M-H, Fixed, 95% CI)1.18 [0.72, 1.94]
 6.8.3 Multi8597RR (M-H, Fixed, 95% CI)0.87 [0.56, 1.33]
 6.8.4 Multi (studies with a few individual sessions removed)3211RR (M-H, Fixed, 95% CI)0.52 [0.21, 1.29]
 6.8.5 Mixed5336RR (M-H, Fixed, 95% CI)1.39 [0.90, 2.16]

From: 10, Clinical evidence summary tables

Cover of Schizophrenia
Schizophrenia: Core Interventions in the Treatment and Management of Schizophrenia in Primary and Secondary Care (Update) [Internet].
NICE Clinical Guidelines, No. 82.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2009 Mar.
Copyright © 2009, National Collaborating Centre for Mental Health.

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