From: 6, Pharmacological interventions in the treatment and management of schizophrenia
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Clozapine vs. haloperidol | Clozapine vs. a non-haloperidol FGAa | |
---|---|---|
k (total N) | 4 (607) | 3 (459) |
Study ID | Buchanan1998
Klieser1989 Rosenheck1997 VOLAVKA2002 | Claghorn1987
Hong1997 Kane1988 |
Diagnostic criteria | DSM-III-R, DSM-IV | DSM-II, DSM -III, DSM-IV |
Selected inclusion criteria | b | c |
Setting | Inpatient/outpatient | Inpatient |
Duration of treatment | Short-term: 6–10
weeks Medium-term: 14 weeks Long-term: 52 weeks | Short-term: 4–8
weeks Medium-term: 12 weeks |
Medication dose (mg/day) | CLZ: 400–552 mg/d (range
of means); 100–900 mg/d (range) HAL: 20–28 mg/d (range of means); 5–30 mg/d (range) | CLZ: 417–543 mg/d (range
of means); 150–900 mg/d (range) CHL: 798–1163 mg/d (range of means); 300–1800 mg/d (range) |
a All three trials used chlorpromazine as the comparator.
b Buchanan1998: Non-complete response to at least two trials of therapeutic doses of antipsychotics for at least 6 weeks; Klieser1989: Chronic treatment-resistant (no diagnostic criteria); Rosenheck1997: Treatment-resistant, high level use of inpatient services; VOLAVKA2002: Sub-optimal response to previous treatment, defined by history of persistent positive symptoms after at least 6 contiguous weeks of treatment with one or more typical antipsychotics at ≥600 mg/d in CHL equivalents, and a poor level of functioning over past 2 years.
c Claghorn1987: Intolerant to at least two prior antipsychotics; Hong1997: Treatment-refractory (Severe psychotic symptoms according to BPRS item scores for >6 months despite treatment with antipsychotics from at least two different classes at dosages of at least 1000 mg CHL equivalents); Kane 1988: 3+ periods of antipsychotic treatment, 1000 mg/day of CHL equivalents without significant symptomatic relief & BPRS total score of at least 45.
From: 6, Pharmacological interventions in the treatment and management of schizophrenia
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.