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Creatinine is a breakdown product of creatine, which is an important part of muscle. This article discusses the laboratory test to measure the amount of creatinine in the blood.
Creatinine can also be measured with a urine test. See: Creatinine - urine
How the test is performed
A blood sample is needed. For information on how this is done, see: Venipuncture
How to prepare for the test
The health care provider may tell you to stop taking certain drugs that may affect the test. Such drugs include:
- Aminoglycosides (for example, gentamicin)
- Heavy metal chemotherapy drugs (for example, cisplatin)
- Kidney damaging drugs such as cephalosporins (for example, cephalexin)
- Nonsteroidal anti-inflammatory drugs (NSAIDs)
- Trimethoprim
How the test will feel
When the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.
Why the test is performed
The test is done to see how well your kidneys work. Creatinine is removed from the body entirely by the kidneys. If kidney function is abnormal, creatinine levels will increase in the blood (because less creatinine is released through your urine).
Creatinine levels also vary according to a person's size and muscle mass.
Normal Values
A normal result is 0.7 to 1.3 mg/dL for men and 0.6 to 1.1 mg/dL for women.
Females usually have a lower creatinine than males, because they usually have less muscle mass.
The examples above are common measurements for results of these tests. Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your doctor about the meaning of your specific test results.
What abnormal results mean
Higher than normal levels may be due to:
- Dehydration
- Eclampsia (a condition of pregnancy that includes seizures)
- Kidney failure
- Preeclampsia (pregnancy-induced hypertension)
- Pyelonephritis
- Reduced kidney blood flow (shock, congestive heart failure)
- Urinary tract obstruction
Lower than normal levels may be due to:
- Muscular dystrophy (late stage)
- Myasthenia gravis
Additional conditions under which the test may be performed:
- Amyloidosis
- Chronic kidney disease
- Cushing syndrome
- Dementia due to metabolic causes
- Dermatomyositis
- Diabetes
- Generalized tonic-clonic seizure
- Membranoproliferative GN I and GN II
- Thrombotic thrombocytopenic purpura
- Wilms' tumor
What the risks are
There is very little risk involved with having your blood taken. Veins and arteries vary in size from one patient to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.
Other risks associated with having blood drawn are slight but may include:
- Excessive bleeding
- Fainting or feeling light-headed
- Hematoma (blood accumulating under the skin)
- Infection (a slight risk any time the skin is broken)
References
- Landry DW, Bazari H. Approach to the patient with renal disease. In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 116.
Review Date: 8/20/2011.
Reviewed by: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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Drugs that aim to prevent the loss of protein or albumin through urine in people with sickle cell disease
Sickle cell disease is a group of inherited disorders that often lead to kidney damage. High protein or albumin levels in urine is a strong predictor of subsequent kidney failure. It is common practice to give angiotensin‐converting enzyme (ACE) inhibitors to reduce the level of protein or albumin in urine, thus protecting the kidneys from damage. However, little is known about how effective and safe these are in patients with sickle cell disease. This review included one study comparing captopril (an ACE inhibitor) to placebo. There were 22 participants in this study and the results were not convincing, with minor analysis changes leading to very different study conclusions. This study did not show that ACE inhibitors could reduce the level of protein or albumin in the urine. The level of creatinine and potassium in the blood were reported constant throughout the study. No serious adverse events were noted, although the potential for causing low blood pressure should be highlighted. More long‐term studies involving multiple centers and larger numbers of participants are warranted.
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- Acute tubular necrosis
- Diabetes and kidney disease
- Eclampsia
- Glomerulonephritis
- Muscular dystrophy
- Preeclampsia
- Rhabdomyolysis
- Acute nephritic syndrome
- Alport syndrome
- Atheroembolic renal disease
- Digitalis toxicity
- Ectopic Cushing syndrome
- Goodpasture syndrome
- Hemolytic-uremic syndrome
- Hepatorenal syndrome
- Interstitial nephritis
- Lupus nephritis
- Malignant hypertension
- Medullary cystic kidney disease
- Membranoproliferative GN
- Polymyositis - adult
- Prerenal azotemia
MedlinePlus.gov links to free, reliable, up-to-date health information from the National Institutes of Health (NIH) and other trusted health organizations.
- Creatinine - bloodCreatinine - bloodPubMed Health
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