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A.D.A.M. Medical Encyclopedia. Atlanta (GA): A.D.A.M.; 2011.

A.D.A.M. Medical Encyclopedia.

Panic disorder

Panic attacks

Last reviewed: April 11, 2011.

Panic disorder is a type of anxiety disorder in which you have repeated attacks of intense fear that something bad will occur when not expected.

See also: Generalized anxiety disorder

Causes, incidence, and risk factors

The cause is unknown. Genetics may play a role. Studies suggest that if one identical twin has panic disorder, the other twin will also develop the condition 40% of the time. However, panic disorder often occurs when there is no family history.

Panic disorder is twice as common in women as in men. Symptoms usually begin before age 25, but may occur in the mid 30s. Although panic disorder may occur in children, it is often not diagnosed until they are older.

Symptoms

A panic attack begins suddenly, and most often peaks within 10 - 20 minutes. Some symptoms may continue for an hour or more. A panic attack may be mistaken for a heart attack.

Panic attacks may include anxiety about being in a situation where an escape may be difficult (such as being in a crowd or traveling in a car or bus).

A person with panic disorder often lives in fear of another attack, and may be afraid to be alone or far from medical help.

People with panic disorder have at least four of the following symptoms during an attack:

Panic attacks may change behavior and function at home, school, or work. People with the disorder often worry about the effects of their panic attacks.

People with panic disorder may have symptoms of:

Panic attacks cannot be predicted. At least in the early stages of the disorder, there is no trigger that starts the attack. Recalling a past attack may trigger panic attacks.

Signs and tests

Many people with panic disorder first seek treatment in the emergency room, because the panic attack feels like a heart attack.

The health care provider will perform a physical examination, including a psychiatric evaluation.

Blood tests will be done. Other medical disorders must be ruled out before panic disorder can be diagnosed. Disorders related to substance abuse should be considered, because symptoms can mimic panic attacks.

Treatment

The goal of treatment is to help you function well during everyday life. A combination of medication and cognitive-behavioral therapy (CBT) works best.

Antidepressant medications called selective serotonin reuptake inhibitors (SSRIs) are most commonly prescribed for panic disorder. These include:

Other medications that may be used include:

  • Other types of antidepressants, such as serotonin-norepinephrine reuptake inhibitors (SNRIs)

  • Antiseizure drugs in severe cases

  • Benzodiazepines, including diazepam (Valium), alprazolam (Xanax), clonazepam (Klonopin), and lorazepam (Ativan) may be used for a short time.

  • Monoamine oxidase inhibitors (MAOIs) are only used when the other drugs do not work, however they can have serious side effects.

Your symptoms should slowly get better over a few weeks. Talk to your doctor if they do not. Do not stop taking your medications without talking with your health care provider.

Cognitive-behavioral therapy helps you understand your behaviors and how to change them. You should have 10 to 20 visits over a number of weeks. During therapy you will learn how to:

  • Understand and control distorted views of life stressors, such as other people's behavior or life events.

  • Recognize and replace panic-causing thoughts, and decrease the sense of helplessness.

  • Manage stress and relax when symptoms occur.

  • Imagine the things that cause the anxiety, starting with the least fearful. Slowly become involved in the real-life situation may help you overcome the fears.

The following may also help reduce the number or severity of panic attacks:

  • Regular exercise

  • Getting enough sleep

  • Regularly scheduled meals

  • Reduce or avoid caffeine, certain cold medicines, and stimulants

Expectations (prognosis)

Panic disorders may be long-lasting and difficult to treat. Some people with this disorder may not be cured with treatment. However, most people get better with a combination of medicine and behavioral therapy.

Complications

Substance abuse can occur when people who have panic attacks try to cope with their fear by using alcohol or illegal drugs.

People with panic disorder are more likely to be unemployed, less productive at work, and to have difficult personal relationships, including marital problems.

Agoraphobia is when the fear of future panic attacks causes someone to avoid situations or places that are thought to cause the attacks. This can lead a person to place severe restrictions on where they go or who they are around. See: Panic disorder with agoraphobia

Dependence on anti-anxiety medications is a possible complication of treatment. Dependence involves needing a medication to be able to function and to avoid withdrawal symptoms. It is not the same as addiction.

Calling your health care provider

Call for an appointment with your health care provider if panic attacks are interfering with your work, relationships, or self-esteem.

Prevention

If you get panic attacks, avoid the following:

  • Alcohol

  • Stimulants such as caffeine and cocaine

These substances may trigger or worsen the symptoms.

References

  1. Hofmann SG, Smits JA. Cognitive-behavioral therapy for adult anxiety disorders: a meta-analysis of randomized placebo-controlled trials. J Clin Psychiatry. 2008;69:621-632. [PubMed: 18363421]
  2. Taylor CT, Pollack MH, LeBeau RT, Simon NM. Anxiety disorders: Panic, social anxiety, and generalized anxiety. In: Stern TA, Rosenbaum JF, Fava M, Biederman J, Rauch SL, eds. Massachusetts General Hospital Comprehensive Clinical Psychiatry. 1st ed. Philadelphia, Pa: Mosby Elsevier;2008:chap 32.
  3. Pollack MH, Kinrys G, Delong H, Vasconcelos e Sá D, Simon NM. The pharmacotherapy of anxiety disorders. Stern TA, Rosenbaum JF, Fava M, Biederman J, Rauch SL, eds. Massachusetts General Hospital Comprehensive Clinical Psychiatry. 1st ed. Philadelphia, Pa: Mosby Elsevier;2008:chap 41.
  4. Stein MB, Goin MK, Pollack MH, Roy-Byrne P, Sareen J, Simon NM, et al. Practice guideline for the treatment of patients with panic disorder. Arlington, VA: American Psychiatric Association, 2009.

Review Date: 4/11/2011.

Reviewed by: David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc., and Fred K. Berger, MD, Addiction and Forensic Psychiatrist, Scripps Memorial Hospital, La Jolla, California.

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What works?

  • Psychotherapy and a benzodiazepine combined for treating panic disorder Psychotherapy and a benzodiazepine combined for treating panic disorder
    Panic disorder is characterised by the repeated occurrence of unexpected panic attacks, during which the individual experiences a strong fear with anticipation of death. These attacks are often accompanied by somatic symptoms such as palpitations, dyspnoea or faintness. Those suffering from panic disorder have persistent anticipatory fear of recurrent attacks and feel anxious even while they have no occurrence of panic attacks for a certain period. Panic disorder is strongly associated with an increased risk for agoraphobia and depression. The prevalence of panic disorder is reported to be around 2 to 3 percent in the general population. Two broad categories of treatment have been shown to be effective in treating panic disorder, one being pharmacotherapy with antidepressants or benzodiazepines, the other being psychotherapy. These treatments are often combined, yet the efficacy of combining psychotherapy and benzodiazepine for panic disorder is unclear, despite its widespread use. This review included randomised controlled trials comparing the combination of psychotherapy and a benzodiazepine with either the psychotherapy or the benzodiazapine alone for people with panic disorder. We were able to include only three trials in this review. Two could be used in the comparison of the combination of psychotherapy and benzodiazepine versus psychotherapy alone and one in the comparison of the combination with benzodiazepine. These comparisons involved just 166 patients and 77 patients, respectively. These small numbers make it difficult to detect any differences between combination treatments and either treatment alone. The trials which compared the combination of treatments with psychotherapy alone (both using behaviour therapy) indicated no differences in response between the two approaches, either during the intervention, at the end of the intervention, or at the last follow‐up time point. The trial which compared the combination of treatments with a benzodiazepine alone demonstrated no differences in response during the intervention. Although the combination of treatments appeared to be more effective than the benzodiazepine alone at the end of treatment, no significant differences were observed at the 7‐month follow‐up. Before evidence‐based treatment recommendations are possible, more randomised controlled trials are required, comparing the combination of psychotherapy and benzodiazepines with either treatment alone, and involving enough people to be able to detect a true difference between the treatments if one exists.
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