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A.D.A.M. Medical Encyclopedia [Internet]. Atlanta (GA): A.D.A.M.; 2013.

A.D.A.M. Medical Encyclopedia.

Calcium pyrophosphate arthritis (Pseudogout)

Calcium pyrophosphate dihydrate deposition disease; CPPD disease; Acute CPPD arthritis; Pseudogout

Last reviewed: April 18, 2014.

Calcium pyrophosphate arthritis (Pseudogout) is a joint disease that can cause attacks of arthritis. Like with gout, crystals form in the joints. But in calcium pyrophosphate arthritis, the crystals are not formed from uric acid.

Causes

Calcium pyrophosphate arthritis is caused by the collection of salt called calcium pyrophosphate dihydrate (CPPD). The buildup of this salt forms crystals in the joints. This leads to attacks of joint swelling and pain in the knees, wrists, ankles, and other joints.

Among older adults, calcium pyrophosphate arthritis is a common cause of sudden (acute) arthritis in one joint.

Calcium pyrophosphate arthritis mainly affects the elderly because joint degeneration and osteoarthritis increases with age. However, it can sometimes affect younger people who have conditions such as:

Because the symptoms are similar, calcium pyrophosphate arthritis can be misdiagnosed as:

Symptoms

  • Attacks of joint pain and fluid buildup in the joint, leading to joint pain, swelling, warmth and redness
  • Chronic (long-term) arthritis

There may be no symptoms between attacks.

Exams and Tests

Carefully testing the joint fluid for crystals can help the doctor diagnose the condition. Because most conditions involving joint pain are treated with the same medicines (such as steroids and nonsteroidal anti-inflammatory drugs), you may still get the right treatment, even if your diagnosis was incorrect at first.

Treatment

Treatment may involve removing fluid to relieve pressure in the joint. A needle is placed into the joint and fluid is removed (aspirated).

Steroid injections may help treat severely swollen joints. Oral steroids are sometimes used when many joints are swollen.

Nonsteroidal anti-inflammatory medications (NSAIDS) may help ease painful attacks. Colchicine may be useful in some people.

Outlook (Prognosis)

Most people do well with treatment to reduce the acute joint pain. A medicine such as colchicine may help prevent repeat attacks. There is no treatment to remove the CPPD crystals.

Possible Complications

Permanent joint damage can occur without treatment.

When to Contact a Medical Professional

Call for an appointment with your health care provider if you have attacks of joint swelling and joint pain.

Prevention

There is no known way to prevent this disorder. However, treating other problems that may cause pseudogout may make the condition less severe, and may help prevent it from developing in patients who don't already have it.

References

  1. Goldman L, Ausiello DA. Goldman's Cecil Medicine. 23rd ed. Philadelphia, PA: Saunders Elsevier; 2007.

Review Date: 4/18/2014.

Reviewed by: Gordon A. Starkebaum, MD, Professor of Medicine, Division of Rheumatology, University of Washington School of Medicine, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.

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The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only — they do not constitute endorsementscof those other sites. © 1997–2011 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

Copyright © 2013, A.D.A.M., Inc.

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org). URAC's accreditation program is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial policy, editorial process and privacy policy. A.D.A.M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health on the Net Foundation (www.hon.ch).

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only — they do not constitute endorsementscof those other sites. © 1997–2011 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

Copyright © 2013, A.D.A.M., Inc.

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