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A.D.A.M. Medical Encyclopedia [Internet]. Atlanta (GA): A.D.A.M.; 2013.

A.D.A.M. Medical Encyclopedia.

Gilbert's disease

Icterus intermittens juvenilis; Low-grade chronic hyperbilirubinemia; Familial non-hemolytic-non-obstructive jaundice; Constitutional liver dysfunction; Unconjugated benign bilirubinemia

Last reviewed: May 13, 2013.

Gilbert's disease is a common disorder passed down through families. It affects the way bilirubin is processed by the liver, and causes the skin to take on a yellow color (jaundice).

Causes

Gilbert's disease affects up 1 in 10 people in some Caucasian groups.

Symptoms

  • Fatigue
  • Yellowing of the skin and whites of the eyes (mild jaundice)

In people with Gilbert's syndrome, jaundice most often appears during times of exertion, stress, and infection, or when they do not eat.

Exams and Tests

A blood test for bilirubin shows changes that occur with Gilbert's disease. The total bilirubin level is mildly elevated, with most being unconjugated bilirubin. Usually the total level is less than 2 mg/dL, and the conjugated bilirubin level is normal.

Gilbert's disease is linked to a genetic problem, but genetic testing is not needed.

Treatment

No treatment is necessary for Gilbert's disease.

Outlook (Prognosis)

Jaundice may come and go throughout life. It is more likely to appear during illnesses such as colds. It does not cause health problems, but it can confuse the results of tests for jaundice.

Possible Complications

There are no known complications.

When to Contact a Medical Professional

Call your health care provider if you have jaundice or pain in the abdomen that does not go away.

Prevention

There is no proven prevention.

References

  1. Berk PD, Korenblat KM. Approach to the patient with jaundice or abnormal liver test results In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 149.
  2. Lidofsky SD. Jaundice. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 9th ed. Philadelphia, Pa: Saunders Elsevier; 2010:chap 20.

Review Date: 5/13/2013.

Reviewed by: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by A.D.A.M. Health Solutions, Ebix, Inc., Editorial Team: David Zieve, MD, MHA, Bethanne Black, Stephanie Slon, and Nissi Wang.

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The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only — they do not constitute endorsementscof those other sites. © 1997–2011 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

Copyright © 2013, A.D.A.M., Inc.

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org). URAC's accreditation program is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial policy, editorial process and privacy policy. A.D.A.M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health on the Net Foundation (www.hon.ch).

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only — they do not constitute endorsementscof those other sites. © 1997–2011 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

Copyright © 2013, A.D.A.M., Inc.

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