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Type 1 Diabetes in Adults: National Clinical Guideline for Diagnosis and Management in Primary and Secondary Care

Type 1 diabetes can, if poorly controlled, produce devastating problems in both the short and the long term. Good control of blood glucose levels reduces the risk of these problems arising, but can be very difficult for patients and carers to achieve. This guideline emphasises that the NHS should provide all patients with the means – and the necessary understanding – to control their diabetes, and that it should help patients integrate the disease management with their other activities and goals. It argues that every person with diabetes should be able to develop their own care plan and utilise effective treatment in a way agreeable to them. The input of various health professionals may be needed to achieve this, and should be readily available. A system of regular monitoring, so that any complications which do develop are picked up at an early stage and treated appropriately, should also be provided.

NICE Clinical Guidelines - National Collaborating Centre for Chronic Conditions (UK).

Version: 2004
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Rheumatoid Arthritis: National Clinical Guideline for Management and Treatment in Adults

There are over 400,000 people with rheumatoid arthritis (RA) in the UK. Although this makes it a common disorder, there are numerous other conditions ahead of it in terms of numbers, and indeed as causes of excess mortality. What this does not capture however, is the dreadful morbidity associated with the disease. The synovitis of RA affects multiple sites causing widespread pain, and the subsequent destruction of the joints can lead to severe disability affecting all aspects of motor function from walking to fine movements of the hand. Furthermore, RA is not simply a disease of the joints but can affect many other organs causing, for example, widespread vasculitis or severe lung fibrosis. More recently it has become apparent that RA is associated with an increased prevalence of coronary artery disease and significant increased risk of premature mortality.

NICE Clinical Guidelines - National Collaborating Centre for Chronic Conditions (UK).

Version: February 2009
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Impact of Gene Expression Profiling Tests on Breast Cancer Outcomes

To assess the evidence that three marketed gene expression-based assays improve prognostic accuracy, treatment choice, and health outcomes in women diagnosed with early stage breast cancer.

Evidence Reports/Technology Assessments - Agency for Healthcare Research and Quality (US).

Version: January 2008
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Introduction

Breast cancer is the most commonly diagnosed cancer in women. This tumor is currently the second leading cause of cancer-related deaths in women in the U.S., with approximately 178,000 new cases and 40,000 deaths expected among U.S. women in 2007. Treatment for breast cancer usually involves surgery to remove the tumor and involved lymph nodes. Frequently, surgery is followed by radiation therapy (in case of breast conservation or in women with large tumors or many involved lymph nodes), endocrine therapy (for essentially all women with tumors that are estrogen receptor (ER)-positive (see Appendix A a Appendixes cited in this report are provided electronically at: http://www.ahrq.gov/clinic/tp/brcgenetp.htm for a list of acronyms), and/or chemotherapy (for women having a high risk for a poor outcome, such as those with large tumors, involved lymph nodes, advanced disease, or inflammatory breast cancer). Chemotherapy administered in addition to surgery is called “adjuvant” chemotherapy. More than three-quarters of all patients are expected to survive with this multi-modality approach.

January 2008

Addressing Challenges in Genetic Test Evaluation: Evaluation Frameworks and Assessment of Analytic Validity [Internet]

This project pursued four objectives related to genetic testing: (1) assess the feasibility of clarifying a set of evaluation frameworks for common testing scenarios; (2) recommend a systematic approach to literature search for evaluating analytic validity; (3) assess the feasibility of clarifying an optimal quality rating instrument for analytic validity studies; and (4) identify existing gaps in evidence on analytic validity and recommend approaches to fill the gaps.

Methods Research Reports - Agency for Healthcare Research and Quality (US).

Version: June 2011
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Alcohol-Use Disorders: Diagnosis, Assessment and Management of Harmful Drinking and Alcohol Dependence

This clinical guideline on alcohol-use disorders was commissioned by NICE and developed by the National Collaborating Centre for Mental Health, and sets out the evidence for the treatment and management of harmful drinking and alcohol dependence in adults and in young people aged 10 to 17 years.

NICE Clinical Guidelines - National Collaborating Centre for Mental Health (UK).

Version: 2011
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Background

Breast cancer is the most common type of cancer in women, with 38,048 new cases registered in women in England and 2457 in Wales in 2007. The usual site of spread outside the breast in newly diagnosed cases is to the lymph nodes in the axilla (underarm). The presence of axillary metastases and the extent of their spread are important prognostic factors for staging disease and planning treatment, whilst removal of any spread is essential to prevent recurrence and wider metastatic spread.

January 2011

Bacterial Meningitis and Meningococcal Septicaemia: Management of Bacterial Meningitis and Meningococcal Septicaemia in Children and Young People Younger than 16 Years in Primary and Secondary Care

This guideline covers bacterial meningitis and meningococcal septicaemia, focusing on management of these conditions in children and young people aged younger than 16 years in primary and secondary care, and using evidence of direct relevance to these age groups where available.

NICE Clinical Guidelines - National Collaborating Centre for Women's and Children's Health (UK).

Version: 2010
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Non-Small Cell Lung Cancer Treatment (PDQ®): Patient Version

Expert-reviewed information summary about the treatment of non-small cell lung cancer.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: May 12, 2015

Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) for the Assessment of Axillary Lymph Node Metastases in Early Breast Cancer: Systematic Review and Economic Evaluation

Breast cancer is the most common type of cancer in women. Evaluation of axillary lymph node metastases is important for breast cancer staging and treatment planning.

Health Technology Assessment - NIHR Journals Library.

Version: January 2011
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Early and Locally Advanced Breast Cancer: Diagnosis and Treatment [Internet]

Breast cancer is the most common cancer in women and its management often presents patients and their healthcare professionals with difficult decisions about the most appropriate treatment. For all those affected by breast cancer (including family and carers) it is important to recognise the impact of this diagnosis, the complexity of treatment options and the wide ranging needs and support required throughout this period of care and beyond. We hope that this document will provide helpful and appropriate guidance to both healthcare professionals and patients on the diagnosis and subsequent management of early and locally advanced breast cancer.

NICE Clinical Guidelines - National Collaborating Centre for Cancer (UK).

Version: February 2009
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Melanoma Treatment (PDQ®): Health Professional Version

Expert-reviewed information summary about the treatment of melanoma.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: July 14, 2015

Melanoma Treatment (PDQ®): Patient Version

Expert-reviewed information summary about the treatment of melanoma.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: May 15, 2015

Breast Cancer Treatment (PDQ®): Health Professional Version

Expert-reviewed information summary about the treatment of ductal carcinoma in situ, lobular carcinoma in situ, and invasive breast cancer.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: July 8, 2015

Biomarkers for Assessing and Managing Iron Deficiency Anemia in Late-Stage Chronic Kidney Disease [Internet]

Anemia is a common complication of chronic kidney disease (CKD) that develops early in the course of CKD, and becomes increasingly severe as the disease progresses. The management of anemia in CKD patients requires an appropriate balance between stimulating the generation of erythroblasts (erythropoiesis) and maintaining sufficient iron levels for optimum hemoglobin (Hb) production. Thus, assessing iron status is integral to both iron and anemia management in CKD patients, as iron is essential for Hb formation (as is erythropoietin). However, classical laboratory biomarkers of iron deficiency exhibit a wide biological variability in CKD. In response, newer, less-variable markers have been proposed.

Comparative Effectiveness Reviews - Agency for Healthcare Research and Quality (US).

Version: October 2012
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