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By mouth: Maintains calcium and phosphorus in your body and makes your bones strong. This medicine is a vitamin.

Oral route, Parenteral route: Vitamins are compounds that you must have for growth and health.

UsesSide effectsLatest evidence reviewsResearch summaries for consumersBrand names

Results: 1 to 20 of 278

Effects of vitamin D on muscle function and performance: a review of evidence from randomized controlled trials

Bibliographic details: Rejnmark L.  Effects of vitamin D on muscle function and performance: a review of evidence from randomized controlled trials. Therapeutic Advances in Chronic Disease 2011; 2(1): 25-37 Available from: http://taj.sagepub.com/content/2/1/25.short

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2011

The case for vitamin D supplementation in multiple sclerosis

Bibliographic details: Ganesh A, Apel S, Metz L, Patten S.  The case for vitamin D supplementation in multiple sclerosis. Multiple Sclerosis and Related Disorders 2013; 2(4): 281-306 Available from: http://www.msard-journal.com/article/S2211-0348(13)00002-3/abstract

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

A review of intravenous versus oral vitamin D hormone therapy in hemodialysis patients

This review compared intravenous and oral vitamin D regimens for the treatment of secondary hyperparathyroidism in haemodialysis patients. The authors concluded that there was insufficient evidence to reach a conclusion about the comparative safety and efficacy of oral and intravenous regimens. These conclusions are likely to be reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2003

Effects of vitamin D supplement on blood pressure: a systematic review

Bibliographic details: Zhang N, Xu XJ, Zhu LS.  Effects of vitamin D supplement on blood pressure: a systematic review. Chinese Journal of Evidence-Based Medicine 2013; 13(1): 86-92 Available from: http://www.cjebm.org.cn/en/oa/DArticle.aspx?type=view&id=20130116

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

Need for additional calcium to reduce the risk of hip fracture with vitamin D supplementation: evidence from a comparative metaanalysis of randomized controlled trials

Bibliographic details: Boonen S, Lips P, Bouillon R, Bischoff-Ferrari H A, Vanderschueren D, Haentjens P.  Need for additional calcium to reduce the risk of hip fracture with vitamin D supplementation: evidence from a comparative metaanalysis of randomized controlled trials. Journal of Clinical Endocrinology and Metabolism 2007; 92(4): 1415-1423

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2007

Vitamin D and gestational diabetes: a systematic review and meta-analysis

Bibliographic details: Poel YH, Hummel P, Lips P, Stam F, van der Ploeg T, Simsek S.  Vitamin D and gestational diabetes: a systematic review and meta-analysis. European Journal of Internal Medicine 2012; 23(5): 465-469 Available from: http://www.ejinme.com/article/S0953-6205(12)00031-3/abstract

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2012

Systematic review: vitamin D and calcium supplementation in prevention of cardiovascular events

This review concluded that limited data suggested moderate-to-high doses of vitamin D supplements may reduce cardiovascular disease risk, but calcium supplements may not. Given the potential for missed studies, clinical differences between studies and paucity of good quality data, the reliability of the pooled results is uncertain. However, the authors' conclusions seemed suitably cautious.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2010

Effects of vitamin D supplementation on strength, physical performance, and falls in older persons: a systematic review

This review examined whether vitamin D supplements improve muscle strength and physical function in older people and reduce falls. The authors concluded that there is insufficient evidence to show that vitamin D alone is effective, although it may be effective when combined with calcium supplements. Despite some weaknesses in the review, the conclusions are likely to be accurate.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2003

Vitamin D and cardiovascular outcomes: a systematic review and meta-analysis

CONTEXT: Several studies found association between vitamin D levels and hypertension, coronary artery calcification, and heart disease.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2011

Effects of vitamin D supplementation on blood pressure

OBJECTIVE: Inconsistent findings from epidemiological studies have continued the controversy over the role of oral vitamin D supplementation in reducing blood pressure in normotensive or hypertensive populations.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2010

Osteoporosis: Can calcium and vitamin D prevent it?

Older people can reduce their risk of osteoporosis by taking calcium supplements every day. It is not clear whether extra vitamin D helps to strengthen people's bones if they do not have a vitamin D deficiency.

Informed Health Online [Internet] - Institute for Quality and Efficiency in Health Care (IQWiG).

Version: April 4, 2012

Prognostic role of vitamin D status and efficacy of vitamin D supplementation in cancer patients: a systematic review

BACKGROUND: Whether or not hypovitaminosis D can influence the prognosis of cancer patients and whether or not vitamin D (vitD) supplementation improves outcome remain controversial.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2011

Effects of vitamin D receptor polymorphisms on urolithiasis risk: a meta-analysis

BACKGROUND: Several studies analyzed the associations of Vitamin D receptor (VDR) polymorphisms with urolithiasis risk in different ethnic groups. However, the results were inconclusive. To evaluate a more precise estimation of the relationship, a meta-analysis was performed.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

Vitamin D with calcium reduces mortality: patient level pooled analysis of 70,528 patients from eight major vitamin D trials

INTRODUCTION: Vitamin D may affect multiple health outcomes. If so, an effect on mortality is to be expected. Using pooled data from randomized controlled trials, we performed individual patient data (IPD) and trial level meta-analyses to assess mortality among participants randomized to either vitamin D alone or vitamin D with calcium.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2012

Vitamin D supplementation in pre-dialysis chronic kidney disease: a systematic review

Vitamin D deficiency is associated with a variety of skeletal, cardiometabolic, and immunologic co-morbidities that are present in chronic kidney disease (CKD). We performed a systematic review to investigate the effects of vitamin D supplementation, in the form of ergocalciferol or cholecalciferol, on various health outcomes in early CKD. Seventeen clinical trials were identified, only two of which were randomized, placebo controlled trials. The majority of studies supplementing with > 2,000 IU/day of cholecalciferol achieved optimal vitamin D status, whereas studies supplementing with ergocalciferol were less consistent. Studies varied widely in their effects on lowering serum parathyroid hormone concentrations. Few studies investigated effects of vitamin D treatment on other clinical health indicators in early CKD. Rigorous studies are necessary to investigate optimal vitamin D dosing strategies in early CKD for the maintenance of adequate vitamin D status, management of secondary hyperparathyroidism and improvement of non-skeletal related clinical outcomes.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2012

Vitamin D supplementation for the treatment of acute childhood pneumonia: a systematic review

Background. Studies have found an increased incidence of vitamin D deficiency in children with pneumonia; however, there is no conclusive data regarding the direct effect of vitamin D supplementation in acute pneumonia. Methods. A comprehensive search was performed of the major electronic databases till September 2013. Randomized controlled trials (RCTs) comparing treatment with vitamin D3 versus placebo in children ≤5 years old with pneumonia were included. Results. Out of 32 full text articles, 2 RCTs including 653 children were eligible for inclusion. One trial used a single 100,000 unit of oral vitamin D3 at the onset of pneumonia. There was no significant difference in the mean (±SD) number of days to recovery between the vitamin D3 and placebo arms (P = 0.17). Another trial used oral vitamin D3 (1000 IU for <1 year and 2000 IU for >1 year) for 5 days in children with severe pneumonia. Median duration of resolution of severe pneumonia was similar in the two groups (intervention, 72 hours; placebo, 64 hours). Duration of hospitalization and time to resolution of tachypnea, chest retractions, and inability to feed were also comparable between the two groups. Conclusions. Oral vitamin D supplementation does not help children under-five with acute pneumonia.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

Vitamin D receptor gene (VDR) polymorphisms and the urolithiasis risk: an updated meta-analysis based on 20 case-control studies

Vitamin D receptor (VDR) plays a key role in calcium metabolism, and is closely related to urinary stone formation (urolithiasis). Previous studies have investigated the associations between VDR single nucleotide polymorphisms (SNPs) (polymorphisms at BsmI, ApaI, FokI, or TaqI cutting sites) and urolithiasis in different populations. However, the results remain inconsistent and controversial. Therefore, meta-analysis was performed to evaluate these associations. Twenty studies that investigated the associations between VDR SNPs and urolithiasis were retrieved. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated under the most appropriate genetic model. The TaqI polymorphism was associated with an increased risk of urolithiasis (tt + Tt vs. TT: OR = 1.253; 95% CI = 1.033-1.520, p = 0.022, I(2) = 0), whereas the ApaI, BsmI, and FokI polymorphisms were not. Stratifying for ethnicity, a slightly increased risk was found among Asians as compared to Whites (OR 1.263, 1.232, respectively, p < 0.01). Deviation from Hardy-Weinberg equilibrium (HWE) was the major source of heterogeneity. In summary, this updated meta-analysis suggests the TaqI polymorphism is associated with urolithiasis risk, whereas BsmI, ApaI, and FokI polymorphisms are not.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

Routine postoperative administration of vitamin D and calcium after total thyroidectomy: a meta-analysis

BACKGROUND: Temporary hypocalcemia is a frequent complication after total thyroidectomy. Routine postoperative administration of vitamin D and calcium can reduce the incidence of symptomatic postoperative hypocalcemia. We undertook a systematic review to assess the effectiveness of this intervention.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2011

Potential benefits of vitamin D supplementation in critically ill patients

AIM: To review potential benefits of vitamin D supplementation in critically ill patients.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

Association between vitamin D dosing regimen and fall prevention in long-term care seniors

INTRODUCTION: The effectiveness of vitamin D in reducing falls among long-term care (LTC) seniors remains nonconclusive. We reviewed how vitamin D dosing regimen could affect rate of fall and number of fallers among LTC seniors.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2011

Systematic Reviews in PubMed

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