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Botulinum toxin type B for cervical dystonia or involuntary positioning of the head

Cervical dystonia is the most common form of focal dystonia and is characterized by involuntary posturing of the head. It is frequently associated with neck pain and may lead to physical disability and social withdrawal. Botulinum toxin type A (BtA) has become the first line therapy but some patients become resistant to this drug. Another serotype of Botulum toxin, type B (BtB) has been developed. Three randomized controlled studies of a single intramuscular injection of BtB (up to a dose of 10,000 Units) showed improvements in the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) total score, which includes measures of disability, severity and pain, and patient assessed measures four weeks after injection and lasting about 16 weeks, even in patients resistant to BtA. Adverse events associated with how the drug works included difficulty in swallowing (dysphagia) and dry mouth.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2009

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