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Results: 7

Antibiotics for whooping cough (pertussis)

Whooping cough is a highly contagious disease caused by pertussis bacteria and may lead to death, particularly in infants less than 12 months of age. Although it can be prevented by routine vaccination, it still affects many people. Thirteen trials involving 2197 participants were included in this review. We found that several antibiotic treatments were equally effective in eliminating the bacteria infecting patients, but they did not alter the clinical outcome. There was insufficient evidence to decide whether there is benefit for treating healthy contacts. Side effects were reported with antibiotics and they varied from one antibiotic to another. The result of the review should be interpreted with caution since this review is based on a limited number of trials and some of these trials involved small numbers of participants.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2013

Acellular vaccines for preventing whooping cough (pertussis) in children

We aimed to answer the question of whether acellular pertussis vaccines are as effective as the whole‐cell vaccines at protecting children against whooping cough (pertussis), but with fewer side effects.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2014

Treatment of the cough in whooping cough

We reviewed the evidence from 12 studies about the effect of treatments for cough in patients with whooping cough.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2014

Vitamin A for preventing acute lower respiratory tract infections in children up to seven years of age

Acute lower respiratory tract infections (LRTIs), especially pneumonia and bronchiolitis, are leading causes of mortality in children up to five years of age. The Global Burden of Disease 2000 project estimated that the annual number of acute respiratory tract infection (ARTI)‐related deaths in children up to five years of age was 2.1 million (excluding deaths caused by measles, whooping cough and neonatal deaths). Others estimate worldwide child deaths from ARTIs at 1.9 million in 2000, 70% of them in Africa and Southeast Asia. Vitamin A deficiency is common in low‐income countries and weakens barriers to infection.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2011

Combined DTP‐HBV‐HIB vaccine versus separately administered DTP‐HBV and HIB vaccines in healthy infants up to two years old

Childhood vaccinations provide an effective method of protection against diseases. The World Health Organization (WHO) recommends that routine infant immunisation programmes include a vaccination against Haemophilus influenzae (H. influenza) type B (HIB) in the combined diphtheria‐tetanus‐pertussis (DTP)‐hepatitis B virus (HBV) vaccination. We compared the combined DTP‐HBV‐HIB vaccine with the separate DTP‐HBV and HIB vaccines. Studies only reported on immunogenicity and reactogenicity.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2012

Interventions that will increase and sustain the uptake of vaccines in low‐ and middle‐income countries.

Millions of children in low‐ and middle‐income countries still die from diseases that could have been prevented with vaccines. In order to reach these children, a variety of interventions have been developed and, in some cases, their effect has been evaluated. The studies in this review took place in both rural and urban areas in several countries, including Pakistan and Ghana. The interventions included organising village meetings where immunisation was discussed and promoted; giving information to mothers during their visits to clinics; and distributing specially designed immunisation cards to remind mothers of their children’s immunisation appointments. The families receiving these interventions were compared to families who only received the usual health services.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2011

Interventions aimed at communities for informing and/or educating about early childhood vaccination

Researchers in The Cochrane Collaboration conducted a review of the effect of informing or educating members of the community about early childhood vaccination. After searching for all relevant studies, they found two studies, published in 2007 and 2009. Their findings are summarised below.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2014

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