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Metoclopramide for the treatment of gastroesophageal reflux disease in infants: a systematic review

This review assessed the efficacy, effectiveness and toxicity of metoclopramide for the treatment of gastroesophageal reflux disease (GERD) in infants. Given the small number of studies found, the lack of similarity between the included studies in terms of population, metoclopramide doses and outcomes, and the small sample sizes and lack of consistency in the literature, the authors' conclusion that there is insufficient evidence to support or oppose the use of metoclopramide for GERD in infants seems appropriate.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2006

Psychosocial treatments of psychological symptoms in dementia: a systematic review of reports meeting quality standards

This review concluded that there was some limited evidence that some psychosocial interventions were more effective in reducing psychological symptoms compared with attention controls, but further more focused research was needed. The authors' conclusions appear fairly cautious, but should still be interpreted with the limitations with the studies and potential for bias in the review in mind.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2009

Ocena skutecznosci probiotykow w leczeniu czynnosciowych bolow brzucha u dzieci i doroslych: systematyczny przeglad pismiennictwa [Probiotic therapy for functional abdominal pain: a systematic review of randomised controlled trials]

Bibliographic details: Gawronska A, Szabunko M, Szajewska H.  Ocena skutecznosci probiotykow w leczeniu czynnosciowych bolow brzucha u dzieci i doroslych: systematyczny przeglad pismiennictwa [Probiotic therapy for functional abdominal pain: a systematic review of randomised controlled trials]. Pediatria Wspolczesna 2005; 7(4): 303-309

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2005

Review article: probiotics for the treatment of irritable bowel syndrome - focus on lactic acid bacteria

BACKGROUND: Irritable bowel syndrome (IBS) is a poorly understood, yet highly prevalent functional gastrointestinal disorder (FGID). The withdrawal, due to adverse events, of a number of pharmacological agents that were approved for the treatment of IBS has left a therapeutic vacuum for patients suffering from the disorder.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2012

Systematic review: the role of different types of fibre in the treatment of irritable bowel syndrome

BACKGROUND: Both high-fibre dietary advice and the prescription of fibre as a bulking agent are very common in primary and secondary care management of irritable bowel syndrome. Irritable bowel syndrome patients with constipation may have delayed intestinal transit. Therefore, fibres that accelerate intestinal transit may be beneficial in these patients. The uncertain benefits reported in several clinical studies, however, have led us to reappraise the value of fibre in irritable bowel syndrome management.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2004

Efficacy of probiotics in irritable bowel syndrome: a meta-analysis of randomized controlled trials

This review evaluated whether probiotics could improve clinical symptoms of patients with irritable bowel syndrome. The authors concluded that probiotics may improve irritable bowel syndrome symptoms compared to placebo. The review appeared well conducted and the authors' conclusions are likely to be reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2008

The efficacy and safety of rifaximin for the irritable bowel syndrome: a systematic review and meta-analysis

The authors concluded that treatment with rifaximin was more effective than placebo for global symptoms and bloating in patients with irritable bowel syndrome. The modest therapeutic gain was similar to that of other therapies. The authors' conclusion for short-term treatment compared with placebo reflects the evidence presented and seems reliable; the comparison with other treatments is not substantiated.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2012

Meta-analysis of probiotics for the treatment of irritable bowel syndrome

This review concluded that probiotic use may be associated with improvement in irritable bowel syndrome symptoms compared to placebo, but these results should be interpreted with caution. This cautious conclusion accurately reflects the nature of the evidence and the results of the review, and appears likely to be reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2008

Evaluation of harm in the pharmacotherapy of irritable bowel syndrome

Tricyclic antidepressants and alosetron were associated with significant numbers needed to harm, compared with rifaximin, for diarrhoea. Selective serotonin re-uptake inhibitors and lubiprostone seemed to be safe, for constipation. The authors' conclusions reflected the evidence presented, but lack of quality assessment, different trial lengths, and small samples in some trials mean that the reliability of the results is unclear.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2012

The place of antibiotics in management of irritable bowel syndrome: a systematic review and meta-analysis

The review found that antibiotics had some beneficial effects in irritable bowel syndrome patients, especially with bloating as the predominant symptom, but could not be recommended because of lack of available evidence; further research is needed. The authors' cautious conclusions are appropriate and reflect the lack of available evidence.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2010

Yield of diagnostic tests for celiac disease in individuals with symptoms suggestive of irritable bowel syndrome

This generally well-conducted review concluded that the prevalence of biopsy-proved celiac disease in individuals meeting the IBS diagnostic criteria is approximately 4% and the odds for biopsy-proved celiac disease is more than four-fold that in healthy controls. Interpretation of the results should be undertaken with some caution due to the limitations of the included studies and the between study heterogeneity.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2009

Psychological treatments for irritable bowel syndrome: a systematic review and meta-analysis

This generally well-conducted meta-analysis looked at the effect of a range of different psychological treatments for improving symptoms related to irritable bowel syndrome. Though the authors concluded that psychological treatment appears beneficial, they added that the available evidence did not allow them to investigate the effects of any specific approach to psychological treatment. A more focused meta-analysis might have been more appropriate.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2004

Systematic review: the effectiveness of hypnotherapy in the management of irritable bowel syndrome

This was a generally well-conducted review that evaluated the efficacy of hypnotherapy in the management of irritable bowel syndrome. Most of the included studies showed an improvement in clinical symptoms, suggesting a significant benefit of hypnotherapy. The authors' cautious conclusions are appropriate given the small size and poor quality of the evidence presented.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2006

Effects of 5-hydroxytryptamine (serotonin) type 3 antagonists on symptom relief and constipation in nonconstipated irritable bowel syndrome: a systematic review and meta-analysis of randomized controlled trials

This review evaluated the effectiveness of 5-hydroxytryptamine (serotonin) antagonists in treating irritable bowel syndrome (IBS). The authors concluded that 5-hydroxytryptamine antagonists significantly improved symptoms of non-constipated IBS and diarrhoea predominant IBS in men and women, but there was an increased risk of constipation. The authors' conclusions reflect the evidence presented and are likely to be reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2008

A systematic review and meta-analysis: probiotics in the treatment of irritable bowel syndrome

The authors concluded that probiotics may alleviate some symptoms of irritable bowel syndrome after several weeks of treatment. Longer-term studies were needed, focused on the type and optimal dose of probiotics and on subgroups of patients who may benefit. The review was well conducted and the conclusions appear reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2009

A systematic review of alternative therapies in the irritable bowel syndrome

This review concluded that there is no strong evidence for the effectiveness of alternative therapies in the treatment of irritable bowel syndrome. This was a poorly conducted review and it is unlikely that the findings are reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2003

Irritable bowel syndrome: What can help?

There are a lot of treatments that aim to relieve the symptoms of irritable bowel syndrome – but not all of them have been tested in high-quality studies. Because the causes of IBS are not clear, it is difficult to find suitable treatments. But research has suggested that at least some medications and treatments may be helpful.Abdominal pain, constipation and diarrhea are the main symptoms of irritable bowel syndrome (IBS). Most people only have mild symptoms that they can cope with fairly well without treatment. Over time they learn to understand their body's signals. But sometimes the symptoms are so strong that they significantly affect people’s everyday lives and cause distress. Then several different treatment options can be considered.

Informed Health Online [Internet] - Institute for Quality and Efficiency in Health Care (IQWiG).

Version: August 1, 2013

Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis

This review concluded that fibre, antispasmodics and peppermint oil are more effective than placebo for treating irritable bowel syndrome. Overall, although the review was generally well conducted, the authors' analyses should be interpreted with caution given their reliance on an often limited number of small and sometimes potentially quite different studies.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2008

A review of the effect of peppermint oil in various gastrointestinal conditions

Bibliographic details: Khvorova Y, Neill J.  A review of the effect of peppermint oil in various gastrointestinal conditions. J.GENCA 2008; 18 (3): 6-15

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2008

Meta-analysis of the effectiveness of Tong Xie Yao Fang in treating irritable bowel syndrome

Bibliographic details: Shi J, Wang C W, Fan K.  Meta-analysis of the effectiveness of Tong Xie Yao Fang in treating irritable bowel syndrome. World Chinese Journal of Digestology 2007; 15(17): 1934-1939

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2007

Medical Encyclopedia

  • Drug Class Review: Newer Antihistamines: Final Report Update 2 [Internet]
    Antihistamines inhibit the effects of histamine at H1 receptors. They have a number of clinical indications including allergic conditions (e.g., rhinitis, dermatoses, atopic dermatitis, contact dermatitis, allergic conjunctivitis, hypersensitivity reactions to drugs, mild transfusion reactions, and urticaria), chronic idiopathic urticaria (CIU), motion sickness, vertigo, and insomnia.
  • Insomnia
    Insomnia is a common condition in which you have trouble falling asleep, staying asleep, or both. This condition can range from mild to severe, depending on how often it occurs and for how long.
  • Sleep Apnea
    Sleep apnea is a common disorder in which you have one or more pauses in breathing or shallow breaths while you sleep.
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Systematic Reviews in PubMed

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