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Results: 14

Genetic variant in KIAA0319, but not in DYX1C1, is associated with risk of dyslexia: an integrated meta-analysis

Bibliographic details: Zou L, Chen W, Shao S, Sun Z, Zhong R, Shi J, Miao X, Song R.  Genetic variant in KIAA0319, but not in DYX1C1, is associated with risk of dyslexia: an integrated meta-analysis. American Journal of Medical Genetics Part B 2012; 159B(8): 970-976 Available from: http://onlinelibrary.wiley.com/doi/10.1002/ajmg.b.32102/abstract

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2012

Music education for improving reading skills in children and adolescents with dyslexia

Despite having average or above average intelligence, people with dyslexia (or developmental dyslexia or specific reading disability) have difficulties with accurate or fluent recognition of words (or both) and poor spelling that cannot be attributed to another cause, such as poor vision or hearing or a lack of teaching or motivation. As a consequence of their difficulties, children and adolescents with dyslexia may experience early academic failure. Some studies suggest that reading skills and musical abilities might be related and that musical training may be able to help in the development of language and literacy skills. As information about the effectiveness of musical learning for children and adolescents is lacking, we searched widely for high‐quality evidence in the form of randomized controlled trials. We did not find any and so it is not possible for us to reliably assess the advantages (or even disadvantages) of music education for improving the reading skills of dyslexic children. Well‐designed research with a large number of participants is required to evaluate potential benefits of musical education for children and adolescents with dyslexia.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2012

Screening for Speech and Language Delay in Preschool Children [Internet]

Speech and language development is a useful initial indicator of a child's overall development and cognitive ability. Identification of children at risk for delay may lead to interventions, increasing chances for improvement. However, screening for speech and language delay is not widely practiced in primary care.

Evidence Syntheses - Agency for Healthcare Research and Quality (US).

Version: February 2006
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Neuromotor, cognitive, language and behavioural outcome in children born following IVF or ICSI: a systematic review

The authors concluded that no increased risk of neurodevelopmental problems was found in children born following in vitro fertilisation or intracytoplasmic sperm injection. But, further good-quality longer-term research was required. There were some limitations to this review, but overall the authors? conclusions reflected the evidence presented. The need for further longer-term research was justified in the text.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2008

A family-based association analysis and meta-analysis of the reading disabilities candidate gene DYX1C1

Reading disabilities (RD) have a significant genetic basis and have shown linkage to multiple regions including chromosome 15q. Dyslexia susceptibility 1 candidate gene 1 (DYX1C1) on chromosome 15q21 was originally proposed as a candidate gene with two potentially functional polymorphisms at the -3G/A and 1249G/T positions showing association with RD. However, subsequent studies have yielded mixed results. We performed a literature review and meta-analysis of the -3G/A and 1249G/T polymorphisms, including new unpublished data from two family-based samples. Ten markers in DYX1C1 were genotyped in the two independently ascertained samples. Single marker and -3G/A:1249G/T haplotype analyses were performed for RD in both samples, and quantitative trait analyses using standardized reading-related measures was performed in one of the samples. For the meta-analysis, we used a random-effects model to summarize studies that tested for association between -3G/A or 1249G/T and RD. No significant association was found between the DYX1C1 SNPs and RD or any of the reading-related measures tested after correction for the number of tests performed. The previously reported risk haplotype (-3A:1249T) was not biased in transmission. A total of 9 and 10 study samples were included in the meta-analysis of the -3G/A and 1249G/T polymorphisms, respectively. Neither polymorphism reached statistical significance, but the heterogeneity for the 1249G/T polymorphism was high. The results of this study do not provide evidence for association between the putatively functional SNPs -3G/A and 1249G/T and RD.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

Health Literacy Interventions and Outcomes: An Updated Systematic Review

To update a 2004 systematic review of health care service use and health outcomes related to differences in health literacy level and interventions designed to improve these outcomes for individuals with low health literacy. Disparities in health outcomes and effectiveness of interventions among different sociodemographic groups were also examined.

Evidence Reports/Technology Assessments - Agency for Healthcare Research and Quality (US).

Version: March 2011
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The Management of Lower Urinary Tract Symptoms in Men [Internet]

The guideline covers men (18 and over) with a clinical working diagnosis of lower urinary tract symptoms (LUTS). Options for conservative, pharmacological, surgical, and complementary or alternative treatments are considered in terms of clinical and cost effectiveness.

NICE Clinical Guidelines - National Clinical Guideline Centre (UK).

Version: 2010
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Referral Guidelines for Suspected Cancer in Adults and Children [Internet]

The guideline is divided into sections which cover in detail specific topics relating to twelve groups of cancers: lung, upper gastrointestinal cancers, lower gastrointestinal cancers, breast cancer, gynaecological cancers, urological cancers, haematological cancers, skin cancers, head and neck including oral cancers, brain/central nervous system cancers, bone and sarcoma, and children’s and young people’s cancers.

NICE Clinical Guidelines - Clinical Governance Research and Development Unit (CGRDU), Department of Health Sciences, University of Leicester.

Version: June 2005
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Screening for visual impairment in children younger than 6 years: Executive summary of final report S05-02, Version 1.0

The main aim of this review was the benefit assessment (i.e. the assessment of patient-relevant outcomes) of screening for visual impairment (universal vision screening) in children up to the age of 6. By diagnosing and treating amblyopia or amblyogenic risk factors as early as possible, paediatric developmental delay and its potentially lifelong consequences should be prevented, or at least ameliorated.

Institute for Quality and Efficiency in Health Care: Executive Summaries [Internet] - Institute for Quality and Efficiency in Health Care (IQWiG).

Version: April 1, 2008

Bacterial Meningitis and Meningococcal Septicaemia: Management of Bacterial Meningitis and Meningococcal Septicaemia in Children and Young People Younger than 16 Years in Primary and Secondary Care

This guideline covers bacterial meningitis and meningococcal septicaemia, focusing on management of these conditions in children and young people aged younger than 16 years in primary and secondary care, and using evidence of direct relevance to these age groups where available.

NICE Clinical Guidelines - National Collaborating Centre for Women's and Children's Health (UK).

Version: 2010
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Attention Deficit Hyperactivity Disorder: Diagnosis and Management of ADHD in Children, Young People and Adults

This guideline has been developed to advise on the treatment and management of attention deficit hyperactivity disorder (ADHD). The guideline recommendations have been developed by a multidisciplinary team of healthcare professionals, service users and carers, and guideline methodologists after careful consideration of the best available evidence. It is intended that the guideline will be useful to clinicians and service commissioners in providing and planning high-quality care for people with ADHD while also emphasising the importance of the experience of care for them and their carers (see Appendix 1 for more details on the scope of the guideline).

NICE Clinical Guidelines - National Collaborating Centre for Mental Health (UK).

Version: 2009
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Depression: The Treatment and Management of Depression in Adults (Updated Edition)

This clinical guideline on depression is an updated edition of the previous guidance (published in 2004). It was commissioned by NICE and developed by the National Collaborating Centre for Mental Health, and sets out clear, evidence- and consensus-based recommendations for healthcare staff on how to treat and manage depression in adults.

NICE Clinical Guidelines - National Collaborating Centre for Mental Health (UK).

Version: 2010
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Nutrition Support for Adults: Oral Nutrition Support, Enteral Tube Feeding and Parenteral Nutrition

These guidelines cover most aspects of nutrition support in adult patients (>18 years) who are either malnourished or are at ‘risk’ of malnutrition. In some cases specific guidance related to patients in specific care settings or with specific diseases has been provided but in general the guidance is applicable to patients whatever their setting (hospital or community) or disease. The guideline therefore includes: information on the prevalence of malnutrition and the benefits of good nutrition; guidance on the appropriate forums for the organisation of nutrition support in all settings; guidance on who should be screened for malnutrition and when, along with the criteria for consideration when assessing patients’ nutritional status; the general indications for nutrition support together with ethical and legal considerations that may arise; guidance on the process and special considerations required to prescribe nutrition support and details information on the important parameters to monitor for patients receiving nutrition support; detailed guidance on the administration of oral, enteral and parenteral nutrition including; the appropriate types of access for enteral and parenteral nutrition and the optimum mode of delivering these; specific guidance on the management of providing nutrition support to patients with dysphagia; issues to consider for patients receiving enteral and parenteral nutrition support in the community; issues arising for patients and their carers.

NICE Clinical Guidelines - National Collaborating Centre for Acute Care (UK).

Version: February 2006
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Impact of Consumer Health Informatics Applications

The objective of the report is to review the evidence on the impact of consumer health informatics (CHI) applications on health outcomes, to identify the knowledge gaps and to make recommendations for future research.

Evidence Reports/Technology Assessments - Agency for Healthcare Research and Quality (US).

Version: October 2009
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