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Dementia: A NICE-SCIE Guideline on Supporting People With Dementia and Their Carers in Health and Social Care

This guideline has been developed to advise on supporting people with dementia and their carers in health and social care. The guideline recommendations have been developed by a multidisciplinary team of health and social care professionals, a person with dementia, carers and guideline methodologists after careful consideration of the best available evidence. It is intended that the guideline will be useful to practitioners and service commissioners in providing and planning high-quality care for those with dementia while also emphasising the importance of the experience of care for people with dementia and carers.

NICE Clinical Guidelines - National Collaborating Centre for Mental Health (UK).

Version: 2007
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The diagnostic utility of cerebrospinal fluid alpha-synuclein analysis in dementia with Lewy bodies: a systematic review and meta-analysis

BACKGROUND: Dementia with Lewy Bodies (DLB) can be difficult to distinguish clinically from other dementias.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

Efficacy and safety of cholinesterase inhibitors and memantine in cognitive impairment in Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies: systematic review with meta-analysis and trial sequential analysis

OBJECTIVE: Recently, several large randomised controlled trials about the treatments of cognitive impairment or dementia due to Parkinson's disease (CIND-PD or PDD) and dementia with Lewy bodies (DLB) were completed. Here, we systematically reviewed the studies (including the recent reports) to provide updated evidence for the treatments of CIND-PD, PDD and DLB.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

Diagnostic accuracy of 123I-FP-CIT (DaTSCAN) in dementia with Lewy bodies: a meta-analysis of published studies

PURPOSE: A systematic meta-analysis of published studies on the diagnostic accuracy of presynaptic dopaminergic imaging with ¹²³I-FP-CIT (DaTSCAN) in dementia with Lewy bodies (DLB).

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2012

No convincing evidence from one trial of the efficacy of cholinesterase inhibitors for dementia with Lewy bodies

The characteristic features of dementia with Lewy bodies are dementia, marked fluctuation of cognitive ability, early and persistent visual hallucinations and spontaneous motor features of Parkinsonism. Other symptoms are repeated falls, syncope, transient disturbances of consciousness, neuroleptic sensitivity, and hallucinations in other modalities. This combination of features can be particularly difficult to manage, as antipsychotic drugs used to treat hallucinations, delusions and agitation will worsen Parkinsonian symptoms. The one included trial (of rivastigmine compared with placebo on 120 patients) showed no statistically significant difference between the two groups at 20 weeks. A possible beneficial effect on neuropsychiatric features was found only in analysis of observed cases, and may therefore be due to bias.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2008

Memantine for Lewy body disorders: systematic review and meta-analysis

OBJECTIVE: To clarify whether memantine is more efficacious in several outcomes and safer than placebo in patients with Lewy body disorders, we performed a meta-analysis of memantine in patients with Lewy body disorders.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

Impact of physical therapy for Parkinson's disease: a critical review of the literature

This review assessed the impact of physical therapy on patients with Parkinson's Disease and concluded that the tasks included in the interventions were not generalisable. Further research was required. Studies were of limited quality and were diverse. The authors' appeared to take these factors into consideration and their conclusions are likely to be reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2007

Non-invasive brain stimulation for Parkinson's disease: a systematic review and meta-analysis of the literature

This review concluded that transcranial magnetic stimulation shows a significant modest positive effect, and that electroconvulsive therapy may also have a significant effect, on the motor function of patients with Parkinson's disease. These conclusions should be regarded with some caution, mainly because of a lack of information on the included studies.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2005

A review of studies describing the use of acetyl cholinesterase inhibitors in Parkinson's disease dementia

This review assessed acetyl cholinesterase inhibitors for Parkinson's disease dementia. The authors concluded that cholinesterase inhibitors have a modest effect on cognitive symptoms but little effect on neuropsychiatric symptoms, and poor tolerability may limit their utility. The lack of a description of the review methods and the use of multiple outcomes make it difficult to comment on the reliability of the conclusions.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2005

Meta-analysis of heart valve abnormalities in Parkinson's disease patients treated with dopamine agonists

This review concluded that valvular heart disease occurs at a similar frequency in Parkinson's disease patients who are treated with two dopamine agonists, and around 26% of these patients show signs of moderate valvular disease. Overall, the review process is likely to have been susceptible to various biases, and the conclusions do not necessarily follow from the presented results.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2007

Efficacy and acceptability of selective serotonin reuptake inhibitors for the treatment of depression in Parkinson's disease: a systematic review and meta-analysis of randomized controlled trials

The review concluded there were no statistically significant differences between selective serotonin reuptake inhibitors and placebo/tricyclic antidepressants for the treatment of depression in Parkinson's disease. The authors' conclusions reflected the evidence presented, but potential for publication bias, a lack of reporting of review methods and quality assessment and methodological limitations with the data should be borne in mind.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2010

Rehabilitation for Parkinson's disease: a systematic review of available evidence

The review evaluated the effectiveness of non-pharmacological rehabilitation interventions for people with Parkinson's disease. The authors concluded that these interventions can affect patients' lives for the better in a variety of ways. However, publication bias cannot be ruled out, the clinical importance of the reported improvements is unclear, and more robust research is needed. Overall, the conclusions appear reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2004

The effects of exercise on balance in persons with Parkinson's disease: a systematic review across the disability spectrum

The review concluded exercise resulted in improvements in postural stability and balance task performance for people with mild to moderate Parkinson's disease. However, the number and quality of the trials and outcomes were limited. The authors' cautious conclusions reflect the evidence presented, but they were based on few trials, some with small sample sizes, and diverse interventions and outcome measurements.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2009

Is physical exercise beneficial for persons with Parkinson's disease?

This review concluded that the limited available evidence suggests that exercise training is beneficial to patients with Parkinson's disease, especially those in the early stages of the disease. Given the small numbers of patients and lack of a 'no exercise' control group in most studies, the authors' conclusions may be over-optimistic.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2006

Comparison of the risk of adverse events with pramipexole and ropinirole in patients with Parkinson's disease: a meta-analysis

This review compared the adverse effects of pramipexole and ropinirole with levodopa and placebo in the treatment of Parkinson's disease. The authors concluded that, compared with placebo, ropinirole appears to increase rates of hypotension and somnolence more than pramipexole, while pramipexole increases hallucinations more than ropinirole. These drugs were not compared directly, thus the authors' conclusions may not be reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2003

The effects of whole body vibration on physical and physiological capability in special populations

This review concluded that whole body vibration had beneficial effects on balance, stability and gait, and physical and physiological properties in the elderly, postmenopausal women and neurological patients compared with conventional treatment. Possible error and bias, poor primary study quality, small sample sizes and possible inappropriate pooling of studies for some outcomes suggests the conclusions should be viewed with caution.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2008

B vitamins and berries and age-related neurodegenerative disorders

This review found insufficient evidence to assess the effects of B vitamin supplementation on cognitive function. The authors' conclusions appear appropriately cautious in view of the poor methodological quality and small sample sizes of many of the included studies.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2006

The effect of whole body vibration in common neurological conditions: a systematic review

The review concluded that there was weak to moderate evidence that whole body vibration had positive effects on postural control, mobility, motor function and strength for neurological conditions, but evidence was limited by the paucity and heterogeneity of studies. Potential for publication and language biases and few studies and small sample sizes, the authors' cautious conclusion appears appropriate.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2008

Aerobic fitness in people with Parkinson's disease: a review of the evidence

The review evaluated effects of increased aerobic exercise in patients with Parkinson?s disease and found that increased aerobic fitness had predominantly functional benefits for people with mild to moderate Parkinson?s disease. The authors made some recommendations for best clinical practice. In view of limitations arising from the review process and the evidence provided, the authors? conclusions may not be reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2009

Enabling functional independence in Parkinson's disease: update on occupational therapy intervention

The review concluded that evidence suggested occupational therapy interventions produced improvements in motor function and quality of life for the duration of therapy in patients with Parkinson's disease. The author's conclusions reflected the evidence presented but, due to weaknesses in the review methodology, lack of reporting of outcomes data, and small sample sizes, they should be viewed with caution.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2010

Medical Encyclopedia

  • Dementia
    Dementia is a loss of brain function that occurs with certain diseases. It affects memory, thinking, language, judgment, and behavior.
  • Secondary parkinsonism
    Secondary parkinsonism is similar to Parkinson disease, but the symptoms are caused by certain medicines, a different nervous system disorder, or another illness.
  • Organic brain syndrome
    Organic brain syndrome (OBS) is a general term that describes decreased mental function due to a medical disease other than a psychiatric illness. It is often used synonymously (but incorrectly) with dementia.
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Systematic Reviews in PubMed

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