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Results: 6

Comparing Beta Blockers

How do beta blockers compare in hypertension?

PubMed Clinical Q&A [Internet] - National Center for Biotechnology Information (US).

Version: October 1, 2010

Beta‐blockers for preventing stroke recurrence

People who have had a stroke or a transient ischaemic attack (TIA) are at risk of having further strokes or heart attacks, or other serious circulatory problems. Beta‐blockers are drugs that reduce heart rate and blood pressure, and have other effects that might also reduce the risks of stroke and heart attack. Searching for studies up to May 2014, we found two high quality trials involving 2193 participants that tested beta‐blockers after stroke in people with a recent stroke or TIA. No clear evidence indicated that beta‐blockers reduced the risk of stroke, heart attack, or death from vascular disease. Participants who received beta blockers instead of placebo showed significantly more adverse effects. More studies with larger samples are needed.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2014

Beta blockers for peripheral arterial disease

Intermittent claudication, the most common symptom of atherosclerotic peripheral arterial disease, results from decreased blood flow to the legs during exercise. Beta blockers, a large group of drugs, have been shown to decrease death among people with high blood pressure and coronary artery disease and are used to treat various disorders. They reduce heart activity but can also inhibit relaxation of smooth muscle in blood vessels, bronchi and the gastrointestinal and genitourinary tracts. The non‐selective beta blockers propranolol, timolol and pindolol are effective at all beta‐adrenergic sites in the body, whereas other beta blockers, such as atenolol and metoprolol, are selective for the heart.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2013

Beta‐blockers for hypertension

Beta‐blockers are not recommended as first line treatment for hypertension as compared to placebo due to their modest effect on stroke and no significant reduction in mortality or coronary heart disease. We asked whether this class of drugs was as good as other classes in preventing death, stroke and heart attacks associated with elevated blood pressure. Thirteen randomised controlled trials suggested that first‐line beta‐blockers for elevated blood pressure were not as good at decreasing mortality and morbidity as other classes of drugs: diuretics, calcium channel blockers, and renin angiotensin system inhibitors.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2012

Treatment of high blood pressure for people with peripheral arterial disease

When blood pressure is consistently high it can lead to complications such as a heart attack (myocardial infarction) or stroke. Both peripheral arterial disease (PAD), a condition that affects the blood vessels (arteries) carrying the blood to the legs, arms, and stomach area, and high blood pressure (hypertension) are associated with atherosclerosis. This is hardening of the arteries which is caused by deposits of fat, cholesterol and other substances inside the blood vessels. PAD is diagnosed when the blood supply to the legs is restricted causing pain and cramping that limits walking (intermittent claudication). It is measured by the walking distance (on a treadmill) before onset of pain (claudication distance) or ankle brachial index (ABI), the ratio of the blood pressure in the arms to the blood pressure in the legs. If the blood pressure is lower in the legs compared to the arms (ABI of less than 1.0) this indicates blocked arteries in the legs (or PAD). PAD can progress to pain at rest and critical limb ischaemia (sudden lack of blood flow to a limb caused by a blood clot or fatty deposit blockage) that requires revascularisation (restoring the blood flow by opening up the blocked blood vessel) or amputation. Treatment of hypertension to reduce cardiovascular events (heart attack or stroke) and death needs careful consideration in people with PAD. Anti‐hypertensive medications may worsen the PAD symptoms by further reducing blood flow and supply of oxygen to the limbs, and may have long‐term effects on disease progression. The evidence from randomised controlled trials (RCTs) examining the risks and benefits of various anti‐hypertensive drugs on measures of PAD is lacking.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2014

Medicines for Early Stage Chronic Kidney Disease: A Review of the Research for Adults With Kidney Disease and Diabetes or High Blood Pressure

This summary will tell you about medicines for people with early stage chronic kidney disease and diabetes, high blood pressure, high cholesterol, or heart or blood vessel diseases. It will explain what research says about the benefits and possible side effects of these medicines. It can help you talk with your doctor about whether or not one of these medicines may be right for you.

Comparative Effectiveness Review Summary Guides for Consumers [Internet] - Agency for Healthcare Research and Quality (US).

Version: October 11, 2012

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