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A systematic critical review on MRI in spondyloarthritis

INTRODUCTION: Magnetic resonance imaging (MRI) has been proven capable of showing inflammatory and structural changes in patients with spondyloarthritis (SpA) and has become widely used in the diagnosis of SpA. Despite this, no systematic reviews evaluate the diagnostic utility of MRI for SpA. Therefore, the objective of this systematic review was to determine the evidence for the utility of MRI in the clinical diagnosis of SpA. The aims were to identify which MRI findings are associated with the diagnosis of SpA and to quantify this association.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2012

Methotrexate for ankylosing spondylitis

Researchers in the Cochrane Collaboration conducted a review about the effect of the drug methotrexate in people with ankylosing spondylitis (AS). They identified three studies, which included 116 participants, that met the inclusion criteria.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2013

Probiotics for maintenance of remission in ulcerative colitis

Ulcerative colitis (UC) is a chronic relapsing inflammatory disorder of the large bowel. Probiotics are living microorganisms that are thought to alter the growth of bacteria in the bowel and reduce inflammation. This review investigated the evidence for the use of probiotics for the maintenance of remission in UC. Four studies were identified which tested the effect of probiotics among 587 patients with UC in remission. The studies ranged in length from 3 to 12 months. We did not find any benefit for probiotic treatment compared to either placebo (pills not containing probiotics) or conventional treatment using mesalazine (a 5‐ASA drug taken by mouth). Probiotic treatment was generally well tolerated but the number of side effects reported was similar to that reported with mesalazine. Common side effects included diarrhoea, mucous secretion, bloody stools, abdominal pain, flatulence and distension, nausea and vomiting and headache. Two of the included studies were relatively small and two had methodological problems, therefore no definite conclusion can be made regarding the effectiveness of probiotic maintenance treatment. Larger, well‐designed randomised controlled trials are required to determine whether probiotics are of benefit for the maintenance of remission in UC.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2012

Drug Class Review: Targeted Immune Modulators: Final Update 3 Report [Internet]

We systematically compared the efficacy, effectiveness, and safety (adverse events) of abatacept, adalimumab, alefacept, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, natalizumab, rituximab, tocilizumab, and ustekinumab in patients with rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, psoriatic arthritis, Crohn’s disease, ulcerative colitis, and plaque psoriasis.

Drug Class Reviews - Oregon Health & Science University.

Version: March 2012
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Etanercept, Infliximab and Adalimumab for the Treatment of Psoriatic Arthritis: A Systematic Review and Economic Evaluation

Etanercept, infliximab and adalimumab are licensed in the UK for the treatment of active and progressive psoriatic arthritis (PsA) in adults who have an inadequate response to standard treatment.

Health Technology Assessment - NIHR Evaluation, Trials and Studies Coordinating Centre (UK).

Version: February 2011
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Complementary and Alternative Therapies for Back Pain II

Back and neck pain are important health problems with serious societal and economic implications. Conventional treatments have been shown to have limited benefit in improving patient outcomes. Complementary and Alternative Medicine (CAM) therapies offer additional options in the management of low back and neck pain. Many trials evaluating CAM therapies have poor quality and inconsistent results.

Evidence Reports/Technology Assessments - Agency for Healthcare Research and Quality (US).

Version: October 2010
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