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Autologous plateletrich plasma (PRP) for chronic wounds

Chronic wounds include pressure ulcers, venous leg ulcers, arterial ulcers, neurotrophic ulcers and foot ulcers in people with diabetes. Autologous plateletrich plasma (PRP) is a potential wound‐healing treatment because it contains fibrin and high concentrations of growth factors that are thought to help healing. This review evaluated the effectiveness and safety of PRP and included nine randomised clinical trials, with a total of 325 participants. There were no differences between the autologous PRP and the control groups in terms of healing. However, these results require confirmation in adequately powered, well conducted RCTs.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2012

Platelet-rich plasma for the treatment of periodontal intrabony defects: a meta-analysis

Bibliographic details: Gao YF, Guo LW, Zhou J, Li SM.  Platelet-rich plasma for the treatment of periodontal intrabony defects: a meta-analysis. Chinese Journal of Evidence-Based Medicine 2013; 13(6): 741-746 Available from: http://www.cjebm.org.cn/oa/DArticle.aspx?type=view&id=20130624

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

Use of platelet rich plasma in intra-articular knee injections

Bibliographic details: Lai L, Stitik T, Desai R, Georgy J.  Use of platelet rich plasma in intra-articular knee injections. American Journal of Physical Medicine and Rehabilitation 2014; 93(3): Supplement a62 Available from: http://journals.lww.com/ajpmr/Citation/2014/03001/Abstracts_of_Scientific_Papers_and_Posters.1.aspx

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

Does plateletrich plasmapheresis (PRP) reduce the need for donor blood

Plateletrich plasmapheresis is a technique that involves a patient’s own blood (autologous whole blood) being withdrawn via an intravenous catheter into a device that separates the blood by centrifugation into red blood cells (RBC), plasma, and a highly concentrated platelet solution. This concentrated autologous platelet solution is returned to the patient at the end of the operation to optimise blood clotting and minimise bleeding. The review of trials found that while PRP can reduce post‐operative blood loss and the need for blood transfusion, other techniques may be more effective.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2011

Effects of platelet-rich plasma on sinus bone graft: meta-analysis

BACKGROUND: This meta-analysis investigates the effects of platelet-rich plasma (PRP) on the sinus bone graft.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2011

Efficacy of autologous platelet-rich plasma use for orthopaedic indications: a meta-analysis

BACKGROUND: The recent emergence of autologous blood concentrates, such as platelet-rich plasma, as a treatment option for patients with orthopaedic injuries has led to an extensive debate about their clinical benefit. We conducted a systematic review and meta-analysis to determine the efficacy of autologous blood concentrates in decreasing pain and improving healing and function in patients with orthopaedic bone and soft-tissue injuries.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2012

The effects of platelet-rich plasma in the treatment of large-joint osteoarthritis: a systematic review

CONTEXT: Osteoarthritis (OA) is a common and costly condition with both operative and nonoperative treatments available. Platelet-rich plasma (PRP) is emerging as a treatment option for a variety of musculoskeletal pathologies, including OA.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

Platelet-rich plasma for long bone healing

OBJECTIVE: To evaluate effectiveness of the use of platelet-rich plasma as coadjuvant for union of long bones.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

Platelet-rich plasma: evidence for the treatment of patellar and Achilles tendinopathy — a systematic review

Platelet-rich plasma (PRP) has been introduced in the clinical practice to treat a growing number of different musculoskeletal pathologies. It is currently applied in the treatment of Achilles and patellar tendinopathies, which are common sport-related injuries very challenging to manage. Aim of the present paper was to review systematically the available clinical evidence concerning the application of PRP in the treatment of patellar and Achilles tendinopathy. A systematic review of the literature was performed according to the following inclusion criteria for relevant articles: (1) clinical reports of any level of evidence, (2) written in the English language, (3) with no time limitation and (4) on the use of PRP to treat conservatively Achilles and patellar tendinopathy. Twenty-two studies were included and analyzed. Two studies on patellar tendinopathy were randomized controlled trials (RCTs), whereas just one RCT was published on Achilles tendon. All the papers concerning patellar tendon reported positive outcome for PRP, which proved to be superior to other traditional approaches such as shock-wave therapy and dry needling. In the case of Achilles tendon, despite the encouraging findings reported by case series, the only RCT available showed no significant clinical difference between PRP and saline solution. The main finding of this study was the paucity of high-level literature regarding the application of PRP in the management of patellar and Achilles tendinopathy. However, the clinical data currently available, although not univocal, suggest considering PRP as a therapeutic option for recalcitrant patellar and Achilles tendinopathies.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

Platelet-rich plasma injections for chronic plantar fasciopathy: a systematic review

INTRODUCTION: There is an increasing interest in platelet-rich plasma (PRP) injection as a treatment for chronic plantar fasciopathy (PF). We wished to evaluate the evidence for the use of PRP in PF/fasciitis.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

Comparative effectiveness of platelet-rich plasma injections for treating knee joint cartilage degenerative pathology: a systematic review and meta-analysis

OBJECTIVE: To explore the effectiveness of platelet-rich plasma (PRP) in treating cartilage degenerative pathology in knee joints.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

Strong evidence against platelet-rich plasma injections for chronic lateral epicondylar tendinopathy: a systematic review

BACKGROUND: Chronic lateral epicondylar tendinopathy is frequent in athletes, and platelet-rich plasma (PRP) is being used increasingly in its treatment.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

Platelet-rich plasma in the treatment of patellar tendinopathy: a systematic review

BACKGROUND: Patellar tendinopathy (PT) is a major cause of morbidity in both high-level and recreational athletes. While there is good evidence for the effectiveness of eccentric exercise regimens in its treatment, a large proportion of patients have disease that is refractory to such treatments. This has led to the development of novel techniques, including platelet-rich plasma (PRP) injection, which aims to stimulate a normal healing response within the abnormal patellar tendon. However, little evidence exists at present to support its use.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

Platelet-rich plasma for treating acute wounds: a meta-analysis

OBJECTIVE: To evaluate the efficacy of platelet-rich plasma (PRP) in the treatment of acute wounds.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

The role of platelet-rich plasma in arthroscopic rotator cuff repair: a systematic review with quantitative synthesis

PURPOSE: Despite the theoretic basis and interest in using platelet-rich plasma (PRP) to improve the potential for rotator cuff healing, there remains ongoing controversy regarding its clinical efficacy. The objective of this systematic review was to identify and summarize the available evidence to compare the efficacy of arthroscopic rotator cuff repair in patients with full-thickness rotator cuff tears who were concomitantly treated with PRP.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2012

Plateletrich therapies for musculoskeletal soft tissue injuries

Muscle, ligament and tendon injuries frequently occur during activities such as sports, and may be due to tissue degeneration. These injuries are more frequent in particular parts of the body, such as the tendons located in the shoulder, elbow, knee and ankle.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2014

Efficacy of platelet-rich plasma injections in osteoarthritis of the knee: a systematic review and meta-analysis

BACKGROUND: The effectiveness of platelet-rich plasma (PRP) injections for osteoarthritis (OA) is still controversial. We investigated the effect of PRP injections in patients with knee OA based on decreasing pain, improving function, global assessment and changes regarding joint imaging.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

The efficacy of platelet-rich plasma in the treatment of symptomatic knee osteoarthritis: a systematic review with quantitative synthesis

PURPOSE: The purpose of this systematic review was to synthesize the available Level I and Level II literature on platelet-rich plasma (PRP) as a therapeutic intervention in the management of symptomatic knee osteoarthritis (OA).

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

Use of platelet rich plasma gel on wound healing: a systematic review and meta-analysis

OBJECTIVE: Autologous platelet rich plasma is an advanced wound therapy used in hard-to-heal acute and chronic wounds. To better understand the use and clinical outcomes of the therapy, a systematic review of the published literature in cutaneous wounds was performed.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2011

Evidence on the use of platelet-rich plasma for diabetic ulcer: a systematic review

This review found that topical treatment with platelet-rich plasma was favourably associated with healing of chronic leg ulcers. However, the authors' conclusions should be interpreted with substantial caution given methodological flaws within the review, poor reporting of the review process and the lack of information provided about the included studies.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2010

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