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The effects of iontophoresis in the treatment of musculoskeletal disorders – a systematic review and meta-analysis

Bibliographic details: Clijsen R, Taeymans J, Baeyens JP, Barel AO, Clarys P.  The effects of iontophoresis in the treatment of musculoskeletal disorders - a systematic review and meta-analysis. Drug Delivery Letters 2012; 2(3): 180-194

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2012

[A systematic review of the evidence on the efficacy of phonophoresis and iontophoresis in the impingement syndrome]

Bibliographic details: Servan-Lopez JL, Lobo-Abad C, Garcia-Martin I, Tenias-Burillo JM, Lopez-Lopez E.  [A systematic review of the evidence on the efficacy of phonophoresis and iontophoresis in the impingement syndrome]. [Revision sistematica de las evidencias sobre la eficacia de la ultrasonoforesis y la iontoforesis en el síndrome subacromial.] Fisioterapia 2012; 34(3): 125-129 Available from: http://www.sciencedirect.com/science/article/pii/S0211563812000041

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2012

Practice parameter: treatment of postherpetic neuralgia. An evidence-based report of the Quality Standards Subcommittee of the American Academy of Neurology

A systematic review of the literature on postherpetic neuralgia was performed. The authors identified studies using the National Library of Medicine's Medline database and Cochrane Library database. The authors determined absolute reduction rate, number needed to treat (NNT), 95% CI for NNT, and number needed to harm (NNH) for successful therapies of postherpetic neuralgia. Tricyclic antidepressants, gabapentin, pregabalin, opioids, and lidocaine patch were found to be effective in reducing the pain of postherpetic neuralgia.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2004

Efficacy of fentanyl iontophoretic transdermal system in postoperative pain: a meta-analysis

The authors concluded that the fentanyl iontophoretic transdermal system appeared safe and was more effective than placebo for acute postoperative analgesia; it was unclear whether it is as effective as morphine patient-controlled analgesia. Potential publication bias and poor reporting of study characteristics, study quality and review methods mean that the authors’ conclusions may require cautious interpretation.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2009

A systematic review and meta-analysis of clinical trials on physical interventions for lateral epicondylalgia

This review assessed physical interventions for lateral epicondylitis. The authors concluded that there was little evidence about the long-term effects of physical therapies, and that further research is required. However, the evidence suggested that extracorporeal shock wave therapy is not effective. The review had some methodological limitations but, overall, the authors' conclusions reflect the limited data.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2005

Physical Therapy Interventions for Knee Pain Secondary to Osteoarthritis [Internet]

To assess the association between intermediate and patient-centered outcomes and harms with physical therapy interventions in community-dwelling adults with chronic knee pain secondary to osteoarthritis and to examine validity and minimum clinically important differences of the tools for outcome measurement.

Comparative Effectiveness Reviews - Agency for Healthcare Research and Quality (US).

Version: November 2012
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Effect of therapeutic modalities on patients with patellofemoral pain syndrome: a systematic review

CONTEXT: Patellofemoral pain syndrome (PFPS) is a common orthopaedic condition for which operative and nonoperative treatments have been used. Therapeutic modalities have been recommended for the treatment of patients with PFPS-including cold, ultrasound, phonophoresis, iontophoresis, neuromuscular electrical stimulation, electrical stimulation for pain control, electromyographic biofeedback, and laser.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2011

Electrotherapy for neck pain

Neck pain is common, disabling and costly. Electrotherapy is an umbrella term that covers a number of therapies using electric current that aim to reduce pain and improve muscle tension and function.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2013

The effectiveness of current dentin desensitizing agents used to treat dental hypersensitivity: a systematic review

OBJECTIVE: Dentin desensitizing agents are used in the treatment of dentin hypersensitivity, which is defined as a painful response in the exposed dentin to stimuli that are thermal, evaporative, tactile, osmotic, or chemical. A systematic review was conducted to analyze the clinical effectiveness of current desensitizer with at least 3 months of follow-up.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

Treatment of medial tibial stress syndrome: a systematic review

This review concluded that the existing evidence for the treatment of medial tibial stress syndrome was of insufficient methodological quality to recommend any specific treatment. The authors recommended further research into extracorporeal shockwave therapy. The review was clearly reported and its conclusions appear to be reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

Treatments for melasma (darker than normal skin occurring in patches)

Melasma is a psychologically distressing skin disorder also known as ‘chloasma’ or ‘mask of pregnancy’. Darker patches of skin gradually develop on the cheeks, forehead, nose, and upper lip. It is more common in women and is associated with pregnancy and medication containing hormones. Melasma is divided into three types: epidermal, dermal, and mixed melasma. Epidermal melasma is the most superficial with an increase in the skin pigment (melanin) in the top layer of skin (epidermis). In dermal melasma, there is increased skin pigment in the second deeper layer of the skin (the dermis). Mixed melasma is a combination of epidermal and dermal melasma.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2010

Exposure to low amounts of ultrasound energy does not improve soft tissue shoulder pathology: a systematic review

The review concluded that further research was needed to determine whether beneficial effects of ultrasound were associated with certain shoulder pathologies or ultrasound protocols. The review was generally well conducted and the authors' conclusions appear appropriate, although the potential for publication and language bias should be borne in mind.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2010

Electrotherapy modalities for adhesive capsulitis (frozen shoulder)

Frozen shoulder is a common cause of shoulder pain and stiffness. The pain and stiffness can last up to two to three years before going away, and in the early stages it can be very painful.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2014

Nonoperative treatment of midportion Achilles tendinopathy: a systematic review

This review concluded that eccentric exercise had the most evidence of effectiveness in the treatment of mid-portion Achilles tendinopathy, and that more research is needed on the value of a range of alternative therapies. The authors’ conclusions reflected the results of the review, but poor reporting and lack of a validity assessment mean that their reliability is unclear.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2009

Effectiveness of physical therapy treatments on lateral epicondylitis

The authors concluded that none of the numerous physical treatments for lateral epicondylitis was shown to be the most effective. Further research was required. The authors’ conclusions appeared to reflect limited findings from diverse studies, but incomplete reporting of review methods and insufficient results data made it difficult to assess the reliability of the authors’ recommendations.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2008

The Use of the Electromotive Drug Administration System in Patients with Overactive Bladder: A Review of the Clinical Effectiveness, Safety, and Cost-Effectiveness [Internet]

Overactive bladder (OAB) is a urological condition characterized by frequent urination, the need to urinate leading to disruption of sleep (nocturia), and urinating unintentionally with or without urge incontinence. OAB is often associated with overactivity of the bladder detrusor muscle, which represents the most common underlying idiopathic or neurogenic dysfunction. It has been estimated that about one in six adults (17%) have OAB, and the prevalence of OAB increases with age. Approximately 10% of children have symptoms that are severe enough to warrant a diagnosis of OAB. Treatment for OAB includes behavioral modifications, pelvic floor rehabilitation, pharmacological agents (e.g., oral medication, intravesical instillation), electrical stimulation, or reconstructive surgery. Intravesical instillation is a local drug delivery system though a catheter into the bladder that is widely used to treat bladder cancer and other conditions. However, some substances are not readily absorbed through the low permeability of the intact urothelium leading to limited effectiveness of the treatment.

Rapid Response Report: Summary with Critical Appraisal - Canadian Agency for Drugs and Technologies in Health.

Version: September 24, 2014
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Applicability of the Evidence Regarding Intensive Glycemic Control and Self-Monitored Blood Glucose to Medicare Patients with Type 2 Diabetes [Internet]

This technology assessment report on intensive glycemic control and self-monitoring of blood glucose (SMBG) in patients with type 2 diabetes mellitus is prepared by the Tufts-New England Medical Center Evidence-based Practice Center (Tufts-NEMC EPC) for a Medicare Evidence Development and Coverage Advisory Committee (MedCAC) meeting. The primary goal of the report is to describe the applicability of the larger, long-duration studies to the nondialysis Medicare population (i.e., people at least 65 years old).

Technology Assessment Report - Agency for Healthcare Research and Quality (US).

Version: September 10, 2007
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Effectiveness of Recombinant Human Growth Hormone (rhGH) in the Treatment of Patients With Cystic Fibrosis [Internet]

This is an evidence report prepared by the University of Connecticut/Hartford Hospital Evidence-based Practice Center (EPC) examining the benefits and harms associated with using recombinant human growth hormone (rhGH) in patients with cystic fibrosis (CF).

Comparative Effectiveness Reviews - Agency for Healthcare Research and Quality (US).

Version: October 2010
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Management of Acute Otitis Media: Update

Acute Otitis Media (AOM), a viral or bacterial infection of the ear, is the most common childhood infection for which antibiotics are prescribed in the United States. In 2001, the Southern California Evidence-based Practice Center conducted a systematic review of the evidence comparing treatments of AOM.

Evidence Reports/Technology Assessments - Agency for Healthcare Research and Quality (US).

Version: November 2010
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The Clinical Effectiveness and Cost-Effectiveness of Management Strategies for Sciatica: Systematic Review and Economic Model

Sciatica is a symptom characterised by well-localised leg pain with a sharp, shooting or burning quality that radiates down the back of the leg and normally to the foot or ankle. It is often associated with numbness or altered sensation in the leg.

Health Technology Assessment - NIHR Journals Library.

Version: November 2011
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