Home > Search Results

Results: 1 to 20 of 311

The intention-to-treat principle in clinical trials and meta-analyses of leukoreduced blood transfusions in surgical patients

BACKGROUND: The scientific method requires that only experiments actually and correctly performed be used to draw conclusions. The intention-to-treat principle requires that all patients, even those not or improperly treated, be included. In clinical trials and meta-analyses investigating leukoreduced blood transfusions to reduce postoperative infections, the intention-to-treat principle and the scientific method have been variably applied.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2007

Guanfacine Hydrochloride Extended Release (Intuniv XR) Tablets: For the Treatment of Attention-Deficit/Hyperactivity Disorder [Internet]

The objective of this review was to compare the clinical benefits and harms of guanfacine extended release (GXR; brand name: Intuniv XR) with those of other active treatments and placebo in children aged six to 12 years with attention-deficit/hyperactivity disorder (ADHD).

Common Drug Review - Canadian Agency for Drugs and Technologies in Health.

Version: July 2015
Show search results within this document

Can community-based peer support promote health literacy and reduce inequalities? A realist review

The review found that community-based programmes are likely to promote health literacy when organisations take the time to negotiate and co-design interventions with the communities and peer-support workers. Top-down authoritarian approaches to design risk limiting ability of peer support workers to deliver culturally tailored support.

Public Health Research - NIHR Journals Library.

Version: February 2015
Show search results within this document

Improving Cultural Competence to Reduce Health Disparities [Internet]

To examine existing system-, clinic-, provider-, and individual-level interventions to improve culturally appropriate health care for people with disabilities; lesbian, gay, bisexual, and transgender (LGBT) populations; and racial/ethnic minority populations.

Comparative Effectiveness Reviews - Agency for Healthcare Research and Quality (US).

Version: March 2016
Show search results within this document

Through the Quality Kaleidoscope: Reflections on the Science and Practice of Improving Health Care Quality: Closing the Quality Gap: Revisiting the State of the Science [Internet]

The United States devotes significant resources to health care, yet quality is often lacking. In 2004, the Agency for Healthcare Research and Quality launched a collection of evidence reports on quality improvement (QI) opportunities and strategies related to chronic conditions, practice areas, and cross-cutting priorities. This new Closing the Quality Gap series expands the topics examined and marshals the knowledge of eight Evidence-based Practice Centers (EPCs) to synthesize lessons learned and to advance the state of QI science.

Methods Research Reports - Agency for Healthcare Research and Quality (US).

Version: February 2013
Show search results within this document

Crime, fear of crime and mental health: synthesis of theory and systematic reviews of interventions and qualitative evidence

Study found that most environmental interventions are not effective at reducing fear of crime, and that fear of crime may be linked to wellbeing as a dimension of social disadvantage.

Public Health Research - NIHR Journals Library.

Version: March 2014
Show search results within this document

Medicines Optimisation: The Safe and Effective Use of Medicines to Enable the Best Possible Outcomes

Striving towards a person-centred service through joint working across health and social care and cross-sector working (for example with commercial organisations) achieves the best possible outcomes for the person. This incorporates a patient's values and preferences and minimises harm, supporting effective medicines optimisation. This guideline reviews the evidence available to support health and social care practitioners, and health and social care organisations, in considering the systems and processes required to ensure safe and effective medicines optimisation.

NICE Guideline - NICE Medicines and Prescribing Centre (UK).

Version: March 2015
Show search results within this document

Utility of cross-matched platelet transfusions in patients with hypoproliferative thrombocytopenia: a systematic review

BACKGROUND: Multiply transfused hypoproliferative thrombocytopenic (HT) patients with alloimmune transfusion refractoriness require specially selected platelets (PLTs). Cross-matching apheresis PLTs is a popular support option, avoiding requirements for large panels of typed donors for HLA-based selection. We undertook a systematic review of the utility of various cross-matching techniques on mortality reduction, prevention of hemorrhage, alloimmunization and refractoriness, and improvement in PLT utilization or count increments.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

Comparative efficacy of vildagliptin and sitagliptin in Japanese patients with type 2 diabetes mellitus: a matching-adjusted indirect comparison of randomized trials

BACKGROUND AND OBJECTIVE: Vildagliptin and sitagliptin are oral dipeptidyl peptidase 4 inhibitors approved in Japan for the treatment of type 2 diabetes mellitus when adequate glycaemic control is not achieved with diet, exercise or sulphonylureas. The aim of this study was to compare 12-week glycaemic control with vildagliptin 50 mg twice daily versus sitagliptin 50 or 100 mg once daily in Japanese patients with type 2 diabetes.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2011

Comparative efficacy of guanfacine extended release versus atomoxetine for the treatment of attention-deficit/hyperactivity disorder in children and adolescents: applying matching-adjusted indirect comparison methodology

This review concluded that guanfacine extended release appeared to be more efficacious than atomoxetine for the treatment of attention deficit hyperactivity disorder in children and adolescents. Concerns about the reporting, the limited number of trials, and the validity of the statistical analysis, mean that these results should be interpreted with caution.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

Caesarean Section

This guidance is a partial update of NICE clinical guideline 13 (published April 2004) and will replace it.

NICE Clinical Guidelines - National Collaborating Centre for Women's and Children's Health (UK).

Version: November 2011
Show search results within this document

Major Trauma: Assessment and Initial Management

This guideline provides guidance on the assessment and management of major trauma, including resuscitation following major blood loss associated with trauma. For the purposes of this guideline, major trauma is defined as an injury or a combination of injuries that are life-threatening and could be life changing because it may result in long-term disability. This guideline covers both the pre-hospital and immediate hospital care of major trauma patients but does not include any management after definitive lifesaving intervention. It has been developed for health practitioners and professionals, patients and carers and commissioners of health services.

NICE Guideline - National Clinical Guideline Centre (UK).

Version: February 2016
Show search results within this document

Intrapartum Care: Care of Healthy Women and Their Babies During Childbirth

The guideline is intended to cover the care of healthy women with uncomplicated pregnancies entering labour at low risk of developing intrapartum complications. In addition, recommendations are included that address the care of women who start labour as ‘low risk’ but who go on to develop complications. These include the care of women with prelabour rupture of membranes at term, care of the woman and baby when meconium is present, indications for continuous cardiotocography, interpretation of cardiotocography traces, and management of retained placenta and postpartum haemorrhage. Aspects of intrapartum care for women at risk of developing intrapartum complications are covered by a range of guidelines on specific conditions (see section 1.8) and a further guideline is planned on intrapartum care of women ‘at high risk’ of complications during pregnancy and the intrapartum period.

NICE Clinical Guidelines - National Collaborating Centre for Women's and Children's Health (UK).

Version: December 2014
Show search results within this document

Preoperative Tests (Update): Routine Preoperative Tests for Elective Surgery

In 2003, NICE first issued guidance on the use of routine preoperative tests for elective surgery (NICE CG3). The guideline evaluated the practice of routinely performing preoperative diagnostic tests for elective surgery in healthy and comorbid populations.

NICE Guideline - National Guideline Centre (UK).

Version: April 2016
Show search results within this document

Blood Transfusion

This guideline contains recommendations about general principles of blood transfusion, and applies to a range of conditions and different settings. It does not include recommendations relating to specific conditions and provides guidance on:

NICE Guideline - National Clinical Guideline Centre (UK).

Version: November 2015
Show search results within this document

Testing Treatments: Better Research for Better Healthcare. 2nd edition

How do we know whether a particular treatment really works? How reliable is the evidence? And how do we ensure that research into medical treatments best meets the needs of patients? These are just a few of the questions addressed in a lively and informative way in Testing Treatments. Brimming with vivid examples, Testing Treatments will inspire both patients and professionals.

Pinter & Martin.

Version: 2011
Show search results within this document

Tuberculosis: Prevention, Diagnosis, Management and Service Organisation

This guideline makes recommendations on the prevention, diagnosis and management of latent and active tuberculosis (TB), including both drug susceptible and drug resistant forms of the disease. It covers the organisation of relevant TB services. It relates to activities undertaken in any setting in which NHS or public health services for TB are received, provided or commissioned in the public, private and voluntary sectors.

NICE Guideline - Internal Clinical Guidelines Team (UK).

Version: January 2016
Show search results within this document

Cost-effectiveness of non-invasive methods for assessment and monitoring of liver fibrosis and cirrhosis in patients with chronic liver disease: systematic review and economic evaluation

The study found that treating all patients with chronic hepatitis C without a prior non-invasive liver test (NILT) is cost-effective; however, recently approved interferon-free regimens were not included. For hepatitis B e antigen (HBeAg)-negative patients, this strategy is cost-effective only if the higher cost-effectiveness threshold is appropriate. For HBeAg-positive patients, two NILTs applied sequentially were cost-effective but highly uncertain. No conclusive results could be obtained for alcoholic and non-alcoholic fatty liver disease. Most studies evaluating non-invasive fibrosis tests had a high risk of bias.

Health Technology Assessment - NIHR Journals Library.

Version: January 2015
Show search results within this document

Informing the NHS Outcomes Framework: evaluating meaningful health outcomes for children with neurodisability using multiple methods including systematic review, qualitative research, Delphi survey and consensus meeting

The study found agreement between young people, parents and professional regarding the most important health outcomes regarding neurodisability for identification through patient-reported outcome measures (PROMs). A systematic review and focus groups were used to examine the effectiveness of PROMs for measuring the specified outcomes, but found that none of the candidate PROMs in the review adequately captured all of these; in addition, there is inadequate evidence that candidate PROMs are psychometrically robust for use with children with neurodisability. Further research is needed to test potential PROMs for use across this population.

Health Services and Delivery Research - NIHR Journals Library.

Version: May 2014
Show search results within this document

Systematic reviews of and integrated report on the quantitative, qualitative and economic evidence base for the management of obesity in men

Study found that sex- and gender-related differences in relation to the content of weight-loss interventions should be recognised and efforts should be made to include accessible, male-friendly intervention settings and that health service staff should initiate discussion regarding weight-loss services.

Health Technology Assessment - NIHR Journals Library.

Version: May 2014
Show search results within this document

Systematic Reviews in PubMed

See all (104)...

Systematic Review Methods in PubMed

See all (5)...

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...