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Cancer that develops in the colon (the longest part of the large intestine) and/or the rectum (the last several inches of the large intestine before the anus).

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Cetuximab for the treatment of metastatic colorectal cancer: a meta-analysis

Bibliographic details: Gao GH, Zhou XL, Huang RF, Jiang JW, Chu ZH, Liang XH.  Cetuximab for the treatment of metastatic colorectal cancer: a meta-analysis. Tumor 2009; 29(3): 253-258

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2009

Irinotecan versus oxaplatin in combination with 5-FU/LV for advanced colorectal cancer: a systematic review

Bibliographic details: Wang T, Luo LL, Zhou QH, Wu TX.  Irinotecan versus oxaplatin in combination with 5-FU/LV for advanced colorectal cancer: a systematic review. Chinese Journal of Evidence-Based Medicine 2008; 8(1): 36-41

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2008

The reduction of adverse drug reaction incidences of colorectal cancer patients receiving Jianpi herbs combined with chemotherapy: a systematic review

Bibliographic details: Liu J, Zhu Q.  The reduction of adverse drug reaction incidences of colorectal cancer patients receiving Jianpi herbs combined with chemotherapy: a systematic review. Chinese Journal of Evidence-Based Medicine 2009; 9(7): 802-808

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2009

Bevacizumab plus chemotherapy as first-line therapy for metastatic colorectal cancer: a systematic review of the efficacy and safety

Bibliographic details: Ni TG, Guan QL, Wang N, Gao C, Zhou X, Yang HT.  Bevacizumab plus chemotherapy as first-line therapy for metastatic colorectal cancer: a systematic review of the efficacy and safety. Tumor 2010; 30(3): 232-238

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2010

KRAS mutations and epidermal growth factor receptor inhibitor therapy in metastatic colorectal cancer

Bibliographic details: Brown HM, Aronson N, Ziegler KM, Bonnell CJ, Gere MA.  KRAS mutations and epidermal growth factor receptor inhibitor therapy in metastatic colorectal cancer. Chicago, IL, USA: Blue Cross and Blue Shield Association, Technology Evaluation Center. Assessment Program; 23,6. 200919297803

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2009

Systematic reviews on selected pharmacogenetic tests for cancer treatment: CYP2D6 for tamoxifen in breast cancer, KRAS for anti-EGFR antibodies in colorectal cancer, and BCR-ABL1 for tyrosine kinase inhibitors in chronic myeloid leukemia

Bibliographic details: Terasawa T, Dahabreh I, Castaldi PJ, Trikalinos TA.  Systematic reviews on selected pharmacogenetic tests for cancer treatment: CYP2D6 for tamoxifen in breast cancer, KRAS for anti-EGFR antibodies in colorectal cancer, and BCR-ABL1 for tyrosine kinase inhibitors in chronic myeloid leukemia. Rockville, MD, USA: Agency for Healthcare Research and Quality. Technology Assessment. 2010 Available from: http://www.cms.gov/medicare-coverage-database/details/technology-assessments-details.aspx?TAId=76&bc=BAAgAAAAAAAA&

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2010

Venous Thromboembolism: Reducing the Risk of Venous Thromboembolism (Deep Vein Thrombosis and Pulmonary Embolism) in Patients Admitted to Hospital

Venous thromboembolism (VTE) is a term used to include the formation of a blood clot (a thrombus) in a vein which may dislodge from its site of origin to travel in the blood, a phenomenon called embolism. A thrombus most commonly occurs in the deep veins of the legs; this is called deep vein thrombosis. A dislodged thrombus that travels to the lungs is known as a pulmonary embolism.

NICE Clinical Guidelines - National Clinical Guideline Centre – Acute and Chronic Conditions (UK).

Version: 2010
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Biomarkers for early detection of colorectal cancer and polyps: systematic review

Bibliographic details: Shah R, Jones E, Vidart V, Kuppen P, Conti J, Francis N.  Biomarkers for early detection of colorectal cancer and polyps: systematic review. Gut 2014; 63(S1): A127-128 Available from: http://gut.bmj.com/content/63/Suppl_1/A127.2

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

Local hepatic therapies for metastases to the liver from unresectable colorectal cancer

Bibliographic details: Belinson S, Chopra R, Yang Y, Shankaran V, Aronson N.  Local hepatic therapies for metastases to the liver from unresectable colorectal cancer. Rockville, MD, USA: Agency for Healthcare Research and Quality. Comparative Effectiveness Review; 93. 201223326895

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2012

Comparison of immunochemical and guaiac-based fecal occult blood test in screening and surveillance for advanced colorectal neoplasms: a meta-analysis

This review concluded that immunochemical faecal occult blood tests could perform better in increasing the detection rate of advanced colorectal neoplasm than guaiac-based tests. There was substantial clinical variation across the included studies. The authors' cautious conclusions and recommendations for research seem appropriate, although it is worth noting that the estimates of diagnostic accuracy for both tests were generally low.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2010

Ursodeoxycholic acid for preventing colorectal cancer in patients with ulcerative colitis: a meta-analysis

Bibliographic details: Cui DJ, Huang B, Zhu M, Ren Y.  Ursodeoxycholic acid for preventing colorectal cancer in patients with ulcerative colitis: a meta-analysis. World Chinese Journal of Digestology 2013; 21(16): 1563-1567

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

Fecal DNA testing in screening for colorectal cancer in average-risk adults

Bibliographic details: Lin JS, Webber EM, Beil TL, Goddard KA, Whitlock EP.  Fecal DNA testing in screening for colorectal cancer in average-risk adults. Rockville, MD, USA: Agency for Healthcare Research and Quality. Comparative Effectiveness Review; 52. 201222457883

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2012

A meta-analysis of the safety of simultaneous versus staged resection for synchronous liver metastasis from colorectal cancer

OBJECTIVE: To evaluate the safety of simultaneous and staged resection for synchronous liver metastasis from colorectal cancer.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2010

Effect of statin therapy on colorectal cancer

Hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, also called statins, are commonly prescribed medications that lower serum cholesterol and decrease cardiac morbidity and mortality. They also possess beneficial effects beyond their cholesterol-lowering properties. Preclinical data suggest statins exhibit pleiotropic antineoplastic effects in a variety of tumours, but clinical studies have provided conflicting data as to whether statins influence the risk of cancer. The biological underpinning of potential effects of statins in colorectal cancer and their role in its prevention or as adjuvant therapy are reviewed. Following a meta-analysis of both randomised clinical trials and epidemiological studies, it is concluded that available clinical data only support a modest, although statistically significant, protective effect of statins in colorectal cancer. Statins may impact on outcomes by decreasing the invasiveness or metastatic properties of colorectal cancer. The data supporting these hypotheses, however, are few and further studies are required to better assess these hypotheses. Statins may also exert a beneficial effect on colorectal cancer by sensitising the tumour to chemotherapeutic agents. Further research is needed to better define the role of statins in overcoming chemoresistance. The combination of statins with other drugs, such as low-dose aspirin or safer non-steroidal anti-inflammatory medications, may be useful in both the prevention and treatment of colorectal cancer.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2010

Laparoscopic versus conventional open surgery for immune function in patients with colorectal cancer.

OBJECTIVE: To systematically evaluate the immune function in patients with colorectal cancer after laparoscopic surgery (LS) and conventional open surgery (OS).

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2011

Systematic review of the effectiveness of population screening for colorectal cancer

AIM: To estimate the effectiveness of colorectal cancer screening with faecal occult blood testing (FOBT), flexible sigmoidoscopy (FS), and combinations of FOBT and FS in preventing colorectal cancer (CRC) deaths.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2007

Systematic review of laparoscopic versus open surgery for colorectal cancer

BACKGROUND: This study compares the efficacy and safety of laparoscopic surgery (LS) and open surgery (OS) for colorectal cancer.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2006

Aberrant methylation of genes in stool samples as diagnostic biomarkers for colorectal cancer or adenomas: a meta-analysis

BACKGROUND: An increasing number of hypermethylated genes in stool samples have been reported as biomarkers for the detection of colorectal cancer (CRC) or adenomas. We aimed to comprehensively review and compare the evidence for feasibility of using these biomarkers for the detection of colorectal neoplasia.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2011

Systematic review of management of colorectal cancer in elderly patients

This study is designed to clarify the benefits and risks of chemotherapy and radiation therapy in elderly patients with colorectal cancer through a systematic review of the literature. Searches of the Medline, Embase, and Cochrane Library databases; PDQ Cancer Information Summaries, American Society of Clinical Oncology Guidelines, Cancer Care Ontario Practice Guideline Initiative, Interprovincial Drug Strategies and Guidelines Group, and OncoLink Web sites; and manual searches of meeting proceedings and bibliographies were performed. Additional studies known to the authors were also identified. Randomized controlled trials, reviews, and guidelines evaluating the impact of age on overall survival and/or toxicity with adjuvant and palliative therapies for colorectal adenocarcinoma were selected. A preset study selection form was applied to all identified studies. All selected studies underwent a preset study appraisal. Analyses of the effect of age on overall survival benefits and/or toxicity of therapy were extracted. A qualitative synthesis and narrative review was undertaken. There is good evidence to support that patients = 80 years of age have similar overall survival benefits with adjuvant 5-fluorouracil (5-FU)-based chemotherapy for colon cancer and with palliative first-line monotherapy for metastatic colorectal cancer, as do younger patients. Data are limited with regard to toxicity of therapy in older patients in these settings. An increase in toxicity with bolus 5-FU chemotherapy regimens is evident. There is a paucity of data regarding adjuvant treatment of older patients with rectal cancer. More elderly patients need to be enrolled in clinical trials in order to fully evaluate the outcomes of colorectal cancer therapy in this population. Further studies are warranted.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2003

Antioxidants in the chemoprevention of colorectal cancer and colorectal adenomas in the general population: a systematic review and meta-analysis

AIM: Antioxidants, such as vitamin A, C and E, selenium and β-carotene, have been proposed as possible agents in the chemoprevention of colorectal cancer and have been the subject of recent trials and reviews. This review aimed to assess the present evidence on the effect of antioxidants on the incidence of colorectal neoplasms in the general population.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2011

Systematic Reviews in PubMed

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