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Year Number of Results
1973 1
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1996 44
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1999 57
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2002 66
2003 78
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2007 90
2008 100
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2,924 results

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Page 1
A Bacterial Effector Reveals the V-ATPase-ATG16L1 Axis that Initiates Xenophagy.
Xu Y, Zhou P, Cheng S, Lu Q, Nowak K, Hopp AK, Li L, Shi X, Zhou Z, Gao W, Li D, He H, Liu X, Ding J, Hottiger MO, Shao F. Xu Y, et al. Cell. 2019 Jul 25;178(3):552-566.e20. doi: 10.1016/j.cell.2019.06.007. Epub 2019 Jul 18. Cell. 2019. PMID: 31327526 Free article.
SopF targeted Gln124 of ATP6V0C in the V-ATPase for ADP-ribosylation. Mutation of Gln124 also blocked xenophagy, but not canonical autophagy. Thus, the discovery of SopF reveals the V-ATPase-ATG16L1 axis that critically mediates autophagic recognition …
SopF targeted Gln124 of ATP6V0C in the V-ATPase for ADP-ribosylation. Mutation of Gln124 also blocked xenophagy, but not canon …
V-ATPase recruitment to ER exit sites switches COPII-mediated transport to lysosomal degradation.
Sun Y, Wang X, Yang X, Wang L, Ding J, Wang CC, Zhang H, Wang X. Sun Y, et al. Dev Cell. 2023 Dec 4;58(23):2761-2775.e5. doi: 10.1016/j.devcel.2023.10.007. Epub 2023 Nov 2. Dev Cell. 2023. PMID: 37922908
Accumulation of misfolded Z-AAT at the ERESs impairs coat protein complex II (COPII)-mediated ER-to-Golgi transport and retains V0 subunits that further assemble V-ATPase at the arrested ERESs. V-ATPase subsequently recruits ATG16L1 onto ERESs to media …
Accumulation of misfolded Z-AAT at the ERESs impairs coat protein complex II (COPII)-mediated ER-to-Golgi transport and retains V0 subunits …
Disorders of lysosomal acidification-The emerging role of v-ATPase in aging and neurodegenerative disease.
Colacurcio DJ, Nixon RA. Colacurcio DJ, et al. Ageing Res Rev. 2016 Dec;32:75-88. doi: 10.1016/j.arr.2016.05.004. Epub 2016 May 16. Ageing Res Rev. 2016. PMID: 27197071 Free PMC article. Review.
Genetic defects of subunits composing the v-ATPase or v-ATPase-related proteins occur in an increasingly recognized group of familial neurodegenerative diseases. Here, we review the expanding roles of the v-ATPase complex as a platform re …
Genetic defects of subunits composing the v-ATPase or v-ATPase-related proteins occur in an increasingly recogni …
Bafilomycin A1 disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A/SERCA-dependent autophagosome-lysosome fusion.
Mauvezin C, Neufeld TP. Mauvezin C, et al. Autophagy. 2015;11(8):1437-8. doi: 10.1080/15548627.2015.1066957. Autophagy. 2015. PMID: 26156798 Free PMC article.
Surprisingly, vesicle fusion remained active in V-ATPase-depleted cells, indicating that autophagosome-lysosome fusion and autolysosome acidification are 2 separable processes. ...Thus, bafilomycin A1 disrupts autophagic flux by independently inhibiting V- …
Surprisingly, vesicle fusion remained active in V-ATPase-depleted cells, indicating that autophagosome-lysosome fusion and aut …
Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly.
Ratto E, Chowdhury SR, Siefert NS, Schneider M, Wittmann M, Helm D, Palm W. Ratto E, et al. Nat Commun. 2022 Aug 17;13(1):4848. doi: 10.1038/s41467-022-32515-6. Nat Commun. 2022. PMID: 35977928 Free PMC article.
Here, we show that mTORC1 blocks lysosomal degradation of extracellular proteins by suppressing V-ATPase-mediated acidification of lysosomes. When mTORC1 is active, peripheral V-ATPase V(1) domains reside in the cytosol where they are stabilized by ass …
Here, we show that mTORC1 blocks lysosomal degradation of extracellular proteins by suppressing V-ATPase-mediated acidificatio …
Schisandrol A protects AGEs-induced neuronal cells death by allosterically targeting ATP6V0d1 subunit of V-ATPase.
Zhou X, Zhao S, Liu T, Yao L, Zhao M, Ye X, Zhang X, Guo Q, Tu P, Zeng K. Zhou X, et al. Acta Pharm Sin B. 2022 Oct;12(10):3843-3860. doi: 10.1016/j.apsb.2022.06.013. Epub 2022 Jun 30. Acta Pharm Sin B. 2022. PMID: 36213534 Free PMC article.
In this study, we discovered a natural small-molecule schisandrol A (SolA) with significant protective effect against AGEs-induced neuronal cell apoptosis. ATP6V0D1, a major subunit of vacuolar-type ATPase (V-ATPase) in lysosome was identified as a crucial cellular …
In this study, we discovered a natural small-molecule schisandrol A (SolA) with significant protective effect against AGEs-induced neuronal …
The Plant V-ATPase.
Seidel T. Seidel T. Front Plant Sci. 2022 Jun 30;13:931777. doi: 10.3389/fpls.2022.931777. eCollection 2022. Front Plant Sci. 2022. PMID: 35845650 Free PMC article. Review.
V-ATPase is the dominant proton pump in plant cells. It contributes to cytosolic pH homeostasis and energizes transport processes across endomembranes of the secretory pathway. ...Furthermore, it is crucial for response to abiotic and biotic stresses. The V- …
V-ATPase is the dominant proton pump in plant cells. It contributes to cytosolic pH homeostasis and energizes transport proces …
Endolysosomal impairment by binding of amyloid beta or MAPT/Tau to V-ATPase and rescue via the HYAL-CD44 axis in Alzheimer disease.
Kim SH, Cho YS, Kim Y, Park J, Yoo SM, Gwak J, Kim Y, Gwon Y, Kam TI, Jung YK. Kim SH, et al. Autophagy. 2023 Aug;19(8):2318-2337. doi: 10.1080/15548627.2023.2181614. Epub 2023 Feb 26. Autophagy. 2023. PMID: 36843263 Free PMC article.
Interestingly, we found that the lumenal ATP6V0C and cytosolic ATP6V1B2 subunits of the V-ATPase complex bound to the internalized Abeta and cytosolic PHF-1-reactive MAPT/Tau, respectively. Their interactions disrupted V-ATPase activity and accompanyin …
Interestingly, we found that the lumenal ATP6V0C and cytosolic ATP6V1B2 subunits of the V-ATPase complex bound to the internal …
Vacuolar H(+)-ATPase.
Xiao YT, Xiang LX, Shao JZ. Xiao YT, et al. Int J Biochem Cell Biol. 2008;40(10):2002-6. doi: 10.1016/j.biocel.2007.08.006. Epub 2007 Aug 22. Int J Biochem Cell Biol. 2008. PMID: 17897871 Review.
The vacuolar H(+)-ATPase (V-ATPase) is a universal component of eukaryotic organisms, which is present in both intracellular compartments and the plasma membrane. ...In this article, we briefly summarize recent studies on the essential and diverse roles of mammalian …
The vacuolar H(+)-ATPase (V-ATPase) is a universal component of eukaryotic organisms, which is present in both intracellular c …
Functional coupling of V-ATPase and CLC-5.
Satoh N, Suzuki M, Nakamura M, Suzuki A, Horita S, Seki G, Moriya K. Satoh N, et al. World J Nephrol. 2017 Jan 6;6(1):14-20. doi: 10.5527/wjn.v6.i1.14. World J Nephrol. 2017. PMID: 28101447 Free PMC article. Review.
Disease aetiology is associated with mutations in the CLCN5 gene coding for the electrogenic 2Cl(-)/H(+) antiporter chloride channel 5 (CLC-5), which is expressed in the apical endosomes of renal proximal tubules with the vacuolar type H(+)-ATPase (V-ATPase). Initia …
Disease aetiology is associated with mutations in the CLCN5 gene coding for the electrogenic 2Cl(-)/H(+) antiporter chloride channel 5 (CLC- …
2,924 results