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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1939 1
1963 2
1968 2
1970 2
1972 3
1974 3
1975 4
1976 5
1977 4
1978 3
1979 3
1980 3
1981 7
1982 4
1983 9
1984 11
1985 13
1986 12
1987 14
1988 15
1989 16
1990 14
1991 15
1992 13
1993 12
1994 23
1995 18
1996 24
1997 10
1998 19
1999 16
2000 15
2001 12
2002 13
2003 20
2004 12
2005 8
2006 12
2007 17
2008 26
2009 15
2010 20
2011 15
2012 22
2013 19
2014 19
2015 29
2016 23
2017 19
2018 23
2019 10
2020 21
2021 21
2022 12
2023 17
2024 5

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686 results

Results by year

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Page 1
Epigenetic Reprogramming in Early Animal Development.
Du Z, Zhang K, Xie W. Du Z, et al. Cold Spring Harb Perspect Biol. 2022 Jun 14;14(6):a039677. doi: 10.1101/cshperspect.a039677. Cold Spring Harb Perspect Biol. 2022. PMID: 34400552 Free PMC article. Review.
Dramatic nuclear reorganization occurs during early development to convert terminally differentiated gametes to a totipotent zygote, which then gives rise to an embryo. Aberrant epigenome resetting severely impairs embryo development and even leads to lethality. ... …
Dramatic nuclear reorganization occurs during early development to convert terminally differentiated gametes to a totipotent zygote, …
Transcription of MERVL retrotransposons is required for preimplantation embryo development.
Sakashita A, Kitano T, Ishizu H, Guo Y, Masuda H, Ariura M, Murano K, Siomi H. Sakashita A, et al. Nat Genet. 2023 Mar;55(3):484-495. doi: 10.1038/s41588-023-01324-y. Epub 2023 Mar 2. Nat Genet. 2023. PMID: 36864102 Free PMC article.
Zygotic genome activation (ZGA) is a critical postfertilization step that promotes totipotency and allows different cell fates to emerge in the developing embryo. ...Both knockdown and CRISPRi-based repression of MERVL result in embryonic lethality due to defects in …
Zygotic genome activation (ZGA) is a critical postfertilization step that promotes totipotency and allows different cell fates to eme …
The Maternal-to-Zygotic Transition in Flowering Plants: Evidence, Mechanisms, and Plasticity.
Baroux C, Grossniklaus U. Baroux C, et al. Curr Top Dev Biol. 2015;113:351-71. doi: 10.1016/bs.ctdb.2015.06.005. Epub 2015 Aug 13. Curr Top Dev Biol. 2015. PMID: 26358878 Review.
The maternal-to-zygotic transition (MZT) defines a developmental phase during which the embryo progressively emancipates itself from a developmental control relying largely on maternal information. The MZT is a functional readout of two processes: the clearance of maternal …
The maternal-to-zygotic transition (MZT) defines a developmental phase during which the embryo progressively emancipates itself from …
Embryo Rescue in Plant Breeding.
Rogo U, Fambrini M, Pugliesi C. Rogo U, et al. Plants (Basel). 2023 Aug 29;12(17):3106. doi: 10.3390/plants12173106. Plants (Basel). 2023. PMID: 37687352 Free PMC article. Review.
However, pre-zygotic and post-zygotic reproductive barriers often present challenges in achieving successful hybridization. ...In certain cases, the in vitro culture of ovule, ovaries or placentas enables the successful development of young embryos from the zygot …
However, pre-zygotic and post-zygotic reproductive barriers often present challenges in achieving successful hybridization. .. …
Zygotic lethal mutations with maternal effect phenotypes in Drosophila melanogaster. II. Loci on the second and third chromosomes identified by P-element-induced mutations.
Perrimon N, Lanjuin A, Arnold C, Noll E. Perrimon N, et al. Genetics. 1996 Dec;144(4):1681-92. doi: 10.1093/genetics/144.4.1681. Genetics. 1996. PMID: 8978055 Free PMC article.
Screens for zygotic lethal mutations that are associated with specific maternal effect lethal phenotypes have only been conducted for the X chromosome. ...
Screens for zygotic lethal mutations that are associated with specific maternal effect lethal phenotypes have only been …
Gene Drive: Evolved and Synthetic.
Burt A, Crisanti A. Burt A, et al. ACS Chem Biol. 2018 Feb 16;13(2):343-346. doi: 10.1021/acschembio.7b01031. Epub 2018 Feb 5. ACS Chem Biol. 2018. PMID: 29400944 Free PMC article. Review.
Genetic elements that can spread by drive include gametic and zygotic killers, meiotic drivers, homing endonuclease genes, B chromosomes, and transposable elements. The fact that gene drive can lead to the spread of fitness-reducing traits (including lethality and s …
Genetic elements that can spread by drive include gametic and zygotic killers, meiotic drivers, homing endonuclease genes, B chromoso …
Cohesin facilitates zygotic genome activation in zebrafish.
Meier M, Grant J, Dowdle A, Thomas A, Gerton J, Collas P, O'Sullivan JM, Horsfield JA. Meier M, et al. Development. 2018 Jan 3;145(1):dev156521. doi: 10.1242/dev.156521. Development. 2018. PMID: 29158440
At zygotic genome activation (ZGA), changes in chromatin structure are associated with new transcription immediately following the maternal-to-zygotic transition (MZT). ...In contrast, CTCF depletion has little effect on ZGA, whereas complete abrogation is lethal …
At zygotic genome activation (ZGA), changes in chromatin structure are associated with new transcription immediately following the ma …
Circumventing Zygotic Lethality to Generate Maternal Mutants in Zebrafish.
Shi DL. Shi DL. Biology (Basel). 2022 Jan 10;11(1):102. doi: 10.3390/biology11010102. Biology (Basel). 2022. PMID: 35053100 Free PMC article.
The CRISPR/Cas9 genome editing technology has provided a powerful tool for creating genetic mutations to study gene functions and developing disease models to identify new therapeutics. However, many maternal genes are also essential after zygotic genome activation; as a r …
The CRISPR/Cas9 genome editing technology has provided a powerful tool for creating genetic mutations to study gene functions and developing …
Maternal-zygotic lethal interactions in Drosophila melanogaster: the effects of deficiencies in the zeste-white region of the X chromosome.
Robbins LG. Robbins LG. Genetics. 1980 Sep;96(1):187-200. doi: 10.1093/genetics/96.1.187. Genetics. 1980. PMID: 6781986 Free PMC article.
Tests of a set of overlapping deficiencies demonstrate that at least three sections of the zeste-white region yield maternal zygotic lethal interactions. Single-cistron mutations at two loci in one of these segments have been tested, and maternal heterozygosity for …
Tests of a set of overlapping deficiencies demonstrate that at least three sections of the zeste-white region yield maternal zygotic …
A maternal-effect Padi6 variant causes nuclear and cytoplasmic abnormalities in oocytes, as well as failure of epigenetic reprogramming and zygotic genome activation in embryos.
Giaccari C, Cecere F, Argenziano L, Pagano A, Galvao A, Acampora D, Rossi G, Hay Mele B, Acurzio B, Coonrod S, Cubellis MV, Cerrato F, Andrews S, Cecconi S, Kelsey G, Riccio A. Giaccari C, et al. Genes Dev. 2024 Mar 22;38(3-4):131-150. doi: 10.1101/gad.351238.123. Genes Dev. 2024. PMID: 38453481 Free PMC article.
Maternal inactivation of genes encoding components of the subcortical maternal complex (SCMC) and its associated member, PADI6, generally results in early embryo lethality. In humans, SCMC gene variants were found in the healthy mothers of children affected by multilocus i …
Maternal inactivation of genes encoding components of the subcortical maternal complex (SCMC) and its associated member, PADI6, generally re …
686 results