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Items: 1 to 20 of 43

1.

Engineered Production of Tryprostatins in E. coli through Reconstitution of a Partial ftm Biosynthetic Gene Cluster from Aspergillus sp.

Shah GR, Wesener SR, Cheng YQ.

Jacobs J Biotechnol Bioeng. 2015 Apr;2(1). pii: 009. Epub 2014 Dec 18.

2.

Target engagement and drug residence time can be observed in living cells with BRET.

Robers MB, Dart ML, Woodroofe CC, Zimprich CA, Kirkland TA, Machleidt T, Kupcho KR, Levin S, Hartnett JR, Zimmerman K, Niles AL, Ohana RF, Daniels DL, Slater M, Wood MG, Cong M, Cheng YQ, Wood KV.

Nat Commun. 2015 Dec 3;6:10091. doi: 10.1038/ncomms10091.

3.

Minimum Information about a Biosynthetic Gene cluster.

Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO.

Nat Chem Biol. 2015 Sep;11(9):625-31. doi: 10.1038/nchembio.1890. No abstract available.

PMID:
26284661
4.

Disulfide cross-linked micelles of novel HDAC inhibitor thailandepsin A for the treatment of breast cancer.

Xiao K, Li YP, Wang C, Ahmad S, Vu M, Kuma K, Cheng YQ, Lam KS.

Biomaterials. 2015 Oct;67:183-93. doi: 10.1016/j.biomaterials.2015.07.033. Epub 2015 Jul 17.

PMID:
26218744
5.

Determination of thailandepsin B in rat plasma with a LC-MS/MS method.

Cheng Z, Ding L, Zhang Y, Chen G, Chen C, Cheng YQ, Jiang H.

Bioanalysis. 2015;7(1):39-52. doi: 10.4155/bio.14.264.

PMID:
25558934
6.

Identification and characterization of the spiruchostatin biosynthetic gene cluster enable yield improvement by overexpressing a transcriptional activator.

Potharla VY, Wang C, Cheng YQ.

J Ind Microbiol Biotechnol. 2014 Sep;41(9):1457-65. doi: 10.1007/s10295-014-1474-8. Epub 2014 Jun 29.

7.

The novel histone deacetylase inhibitor thailandepsin A inhibits anaplastic thyroid cancer growth.

Weinlander E, Somnay Y, Harrison AD, Wang C, Cheng YQ, Jaskula-Sztul R, Yu XM, Chen H.

J Surg Res. 2014 Jul;190(1):191-7. doi: 10.1016/j.jss.2014.02.042. Epub 2014 Feb 28.

8.

The structural basis of an NADP⁺-independent dithiol oxidase in FK228 biosynthesis.

Li J, Wang C, Zhang ZM, Cheng YQ, Zhou J.

Sci Rep. 2014 Feb 20;4:4145. doi: 10.1038/srep04145.

9.

Genome-guided discovery of diverse natural products from Burkholderia sp.

Liu X, Cheng YQ.

J Ind Microbiol Biotechnol. 2014 Feb;41(2):275-84. doi: 10.1007/s10295-013-1376-1. Epub 2013 Nov 9. Review.

11.

Activation of ClpP protease by ADEP antibiotics: insights from hydrogen exchange mass spectrometry.

Sowole MA, Alexopoulos JA, Cheng YQ, Ortega J, Konermann L.

J Mol Biol. 2013 Nov 15;425(22):4508-19. doi: 10.1016/j.jmb.2013.08.005. Epub 2013 Aug 13.

PMID:
23948506
12.

Structural determinants stabilizing the axial channel of ClpP for substrate translocation.

Alexopoulos J, Ahsan B, Homchaudhuri L, Husain N, Cheng YQ, Ortega J.

Mol Microbiol. 2013 Oct;90(1):167-80. doi: 10.1111/mmi.12356. Epub 2013 Aug 23.

13.

Inactivation of cyclic Di-GMP binding protein TDE0214 affects the motility, biofilm formation, and virulence of Treponema denticola.

Bian J, Liu X, Cheng YQ, Li C.

J Bacteriol. 2013 Sep;195(17):3897-905. doi: 10.1128/JB.00610-13. Epub 2013 Jun 21.

14.

Isolation and characterization of spliceostatin B, a new analogue of FR901464, from Pseudomonas sp. No. 2663.

Liu X, Biswas S, Tang GL, Cheng YQ.

J Antibiot (Tokyo). 2013 Sep;66(9):555-8. doi: 10.1038/ja.2013.38. Epub 2013 May 8. No abstract available.

15.

Effects of thailanstatins on glucocorticoid response in trabecular meshwork and steroid-induced glaucoma.

Jain A, Liu X, Wordinger RJ, Yorio T, Cheng YQ, Clark AF.

Invest Ophthalmol Vis Sci. 2013 May 3;54(5):3137-42. doi: 10.1167/iovs.12-11480.

16.

Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43.

Liu X, Biswas S, Berg MG, Antapli CM, Xie F, Wang Q, Tang MC, Tang GL, Zhang L, Dreyfuss G, Cheng YQ.

J Nat Prod. 2013 Apr 26;76(4):685-93. doi: 10.1021/np300913h. Epub 2013 Mar 21.

17.

Cyclo-(-l-prolyl-l-valinyl-) from Burkholderia thailandensis MSMB43.

Liu XY, Wang C, Cheng YQ.

Acta Crystallogr Sect E Struct Rep Online. 2012 Nov 1;68(Pt 11):o3182-3. doi: 10.1107/S1600536812043000. Epub 2012 Oct 20.

18.

FK228 from Burkholderia thailandensis MSMB43.

Liu XY, Wang C, Cheng YQ.

Acta Crystallogr Sect E Struct Rep Online. 2012 Sep 1;68(Pt 9):o2757-8. doi: 10.1107/S160053681203601X. Epub 2012 Aug 23.

19.

Revised genome sequence of Burkholderia thailandensis MSMB43 with improved annotation.

Zhuo Y, Liu L, Wang Q, Liu X, Ren B, Liu M, Ni P, Cheng YQ, Zhang L.

J Bacteriol. 2012 Sep;194(17):4749-50. doi: 10.1128/JB.00931-12.

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