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Year Number of Results
1963 1
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2000 1
2004 2
2005 4
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2007 1
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2009 3
2010 5
2011 6
2012 6
2013 3
2015 7
2016 6
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2023 8
2024 3

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97 results

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Tucatinib plus trastuzumab for chemotherapy-refractory, HER2-positive, RAS wild-type unresectable or metastatic colorectal cancer (MOUNTAINEER): a multicentre, open-label, phase 2 study.
Strickler JH, Cercek A, Siena S, André T, Ng K, Van Cutsem E, Wu C, Paulson AS, Hubbard JM, Coveler AL, Fountzilas C, Kardosh A, Kasi PM, Lenz HJ, Ciombor KK, Elez E, Bajor DL, Cremolini C, Sanchez F, Stecher M, Feng W, Bekaii-Saab TS; MOUNTAINEER investigators. Strickler JH, et al. Lancet Oncol. 2023 May;24(5):496-508. doi: 10.1016/S1470-2045(23)00150-X. Lancet Oncol. 2023. PMID: 37142372 Clinical Trial.
We assessed the activity of tucatinib plus trastuzumab in patients with chemotherapy-refractory, HER2-positive, RAS wild-type unresectable or metastatic colorectal cancer. METHODS: MOUNTAINEER is a global, open-label, phase 2 study that enrolled patients aged 18 years and …
We assessed the activity of tucatinib plus trastuzumab in patients with chemotherapy-refractory, HER2-positive, RAS wild-type unresec …
"Wild child" follow-up.
Terr LC. Terr LC. J Am Acad Child Adolesc Psychiatry. 2004 Oct;43(10):1188. doi: 10.1097/01.chi.0000135643.96313.a7. J Am Acad Child Adolesc Psychiatry. 2004. PMID: 15381876 No abstract available.
Consciousness in Animals.
Johnson AT. Johnson AT. IEEE Pulse. 2020 Mar-Apr;11(2):29-30. doi: 10.1109/MPULS.2020.2984306. IEEE Pulse. 2020. PMID: 32386136
This question has intrigued me for most of my life. Having kept pets and livestock animals, and observed wild animals from both near and far, I have often wondered just how much they know about their surroundings and their place in it. ...Can they see themselves inside the …
This question has intrigued me for most of my life. Having kept pets and livestock animals, and observed wild animals from both near …
Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial.
Swisher EM, Lin KK, Oza AM, Scott CL, Giordano H, Sun J, Konecny GE, Coleman RL, Tinker AV, O'Malley DM, Kristeleit RS, Ma L, Bell-McGuinn KM, Brenton JD, Cragun JM, Oaknin A, Ray-Coquard I, Harrell MI, Mann E, Kaufmann SH, Floquet A, Leary A, Harding TC, Goble S, Maloney L, Isaacson J, Allen AR, Rolfe L, Yelensky R, Raponi M, McNeish IA. Swisher EM, et al. Lancet Oncol. 2017 Jan;18(1):75-87. doi: 10.1016/S1470-2045(16)30559-9. Epub 2016 Nov 29. Lancet Oncol. 2017. PMID: 27908594 Free article. Clinical Trial.
In ARIEL2 Part 1, patients with recurrent, platinum-sensitive, high-grade ovarian carcinoma were classified into one of three predefined homologous recombination deficiency subgroups on the basis of tumour mutational analysis: BRCA mutant (deleterious germline or somatic), BRCA …
In ARIEL2 Part 1, patients with recurrent, platinum-sensitive, high-grade ovarian carcinoma were classified into one of three predefined hom …
Genetically Modified Rabbits for Cardiovascular Research.
Fan J, Wang Y, Chen YE. Fan J, et al. Front Genet. 2021 Feb 2;12:614379. doi: 10.3389/fgene.2021.614379. eCollection 2021. Front Genet. 2021. PMID: 33603774 Free PMC article. Review.
Rabbits are one of the most used experimental animals for investigating the mechanisms of human cardiovascular disease and lipid metabolism because they are phylogenetically closer to human than rodents (mice and rats). Cholesterol-fed wild-type rabbits were first used to …
Rabbits are one of the most used experimental animals for investigating the mechanisms of human cardiovascular disease and lipid metabolism …
CSE1L is a negative regulator of the RB-DREAM pathway in p53 wild-type NSCLC and can be targeted using an HDAC1/2 inhibitor.
Duan L, Tadi MJ, Maki CG. Duan L, et al. Sci Rep. 2023 Sep 27;13(1):16271. doi: 10.1038/s41598-023-43218-3. Sci Rep. 2023. PMID: 37759078 Free PMC article.
We recently reported RBL2-DREAM contributes to improved therapy responses in p53 wild-type NSCLC cells and improved outcomes in NSCLC patients whose tumors express wild-type p53. ...High expression of CSE1L and DREAM target genes could serve as a bioma …
We recently reported RBL2-DREAM contributes to improved therapy responses in p53 wild-type NSCLC cells and improved outcomes i …
Fibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organs.
Wang W, Bale S, Wei J, Yalavarthi B, Bhattacharyya D, Yan JJ, Abdala-Valencia H, Xu D, Sun H, Marangoni RG, Herzog E, Berdnikovs S, Miller SD, Sawalha AH, Tsou PS, Awaji K, Yamashita T, Sato S, Asano Y, Tiruppathi C, Yeldandi A, Schock BC, Bhattacharyya S, Varga J. Wang W, et al. Nat Commun. 2022 Oct 26;13(1):6358. doi: 10.1038/s41467-022-33767-y. Nat Commun. 2022. PMID: 36289219 Free PMC article.
Mice haploinsufficient for A20, or harboring fibroblasts-specific A20 deletion, recapitulate major pathological features of SSc, whereas DREAM-null mice with elevated A20 expression are protected. In DREAM-null fibroblasts, TGF-beta induces the expression of A20, co …
Mice haploinsufficient for A20, or harboring fibroblasts-specific A20 deletion, recapitulate major pathological features of SSc, whereas …
Global polio eradication; can we replicate the smallpox success story?
Javed H, Rizvi MA, Fahim Z, Ehsan M, Javed M, Raza MA. Javed H, et al. Rev Med Virol. 2023 May;33(3):e2409. doi: 10.1002/rmv.2409. Epub 2022 Nov 25. Rev Med Virol. 2023. PMID: 36426668
In the two endemic countries, Pakistan and Afghanistan, a staggering 176 cases of wild poliovirus 1 (WPV1) were reported in 2019. In 2020 alone, 959 cases of Circulating Vaccine Derived Poliovirus 2 were reported globally from 27 countries. ...Governments all over the worl …
In the two endemic countries, Pakistan and Afghanistan, a staggering 176 cases of wild poliovirus 1 (WPV1) were reported in 2019. In …
97 results