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Wedelolactone: A molecule of interests.
Ha NM, Hop NQ, Son NT. Ha NM, et al. Fitoterapia. 2023 Jan;164:105355. doi: 10.1016/j.fitote.2022.105355. Epub 2022 Nov 21. Fitoterapia. 2023. PMID: 36410612 Review.
The combination of wedelolactone and potential agents is a preferential approach to improve its biomedical values. ...CONCLUSIONS: Wedelolactone is a promising agent with the great pharmacological values. ...
The combination of wedelolactone and potential agents is a preferential approach to improve its biomedical values. ...CONCLUSIONS: …
Macrophage Inactivation by Small Molecule Wedelolactone via Targeting sEH for the Treatment of LPS-Induced Acute Lung Injury.
Zhang J, Zhang M, Huo XK, Ning J, Yu ZL, Morisseau C, Sun CP, Hammock BD, Ma XC. Zhang J, et al. ACS Cent Sci. 2023 Feb 21;9(3):440-456. doi: 10.1021/acscentsci.2c01424. eCollection 2023 Mar 22. ACS Cent Sci. 2023. PMID: 36968547 Free PMC article.
Here, we investigate the possible role of sEH in lipopolysaccharide (LPS)-mediated macrophage activation and acute lung injury (ALI). In this study, we found that a small molecule, wedelolactone (WED), targeted sEH and led to macrophage inactivation. ...
Here, we investigate the possible role of sEH in lipopolysaccharide (LPS)-mediated macrophage activation and acute lung injury (ALI). In thi …
Wedelolactone Promotes the Chondrogenic Differentiation of Mesenchymal Stem Cells by Suppressing EZH2.
Qin W, Yang L, Chen X, Ye S, Liu A, Chen D, Hu K. Qin W, et al. Int J Stem Cells. 2023 Aug 30;16(3):326-341. doi: 10.15283/ijsc22046. Epub 2023 Jun 30. Int J Stem Cells. 2023. PMID: 36310024 Free PMC article.
Moreover, the forkhead box O (FOXO) signaling pathway was upregulated by wedelolactone during chondrogenic differentiation, and a FOXO1 inhibitor attenuated the effect of wedelolactone on chondrocyte differentiation. ...Wedelolactone may therefore improve car …
Moreover, the forkhead box O (FOXO) signaling pathway was upregulated by wedelolactone during chondrogenic differentiation, and a FOX …
[Wedelolactone alleviates hyperoxia-induced acute lung injury by regulating ferroptosis].
Liu J, Qin S, Feng B, Chen M, Mei H. Liu J, et al. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2023 Nov;35(11):1177-1181. doi: 10.3760/cma.j.cn121430-20230324-00212. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2023. PMID: 37987128 Chinese.
METHODS: A total of 24 C57BL/6J mice were randomly divided into normal oxygen control group, HALI model group and wedelolactone pretreatment group, with 8 mice in each group. Mice in wedelolactone pretreatment group were treated with wedelolactone 50 mg/kg in …
METHODS: A total of 24 C57BL/6J mice were randomly divided into normal oxygen control group, HALI model group and wedelolactone pretr …
Wedelolactone suppresses IL-1beta maturation and neutrophil infiltration in Aspergillus fumigatus keratitis.
Cheng M, Lin J, Li C, Zhao W, Yang H, Lv L, Che C. Cheng M, et al. Int Immunopharmacol. 2019 Aug;73:17-22. doi: 10.1016/j.intimp.2019.04.050. Epub 2019 May 9. Int Immunopharmacol. 2019. PMID: 31078922
However, the effects of wedelolactone on fungal keratitis are not known. Hence, we aimed to characterize the impact of wedelolactone in Aspergillus fumigatus keratitis. ...Combined with natamycin, wedelolactone protected corneal transparency in mouse with fun …
However, the effects of wedelolactone on fungal keratitis are not known. Hence, we aimed to characterize the impact of wedelolacto …
Wedelolactone, a Component from Eclipta prostrata (L.) L., Inhibits the Proliferation and Migration of Head and Neck Squamous Cancer Cells through the AhR Pathway.
Zou YX, Mu ZQ, Wang J, Tian S, Li Y, Liu Y. Zou YX, et al. Curr Pharm Biotechnol. 2022;23(15):1883-1892. doi: 10.2174/1389201023666220307110554. Curr Pharm Biotechnol. 2022. PMID: 35255785
AhR, CYP1A1, and CYP1B1 levels were examined to uncover the mechanism of inhibition of cell migration by wedelolactone. RESULTS: We found that EAE and wedelolactone decreased the proliferation of human SCC-4 cells and mouse CU110-1 cells at doses of EAE at > 25 m …
AhR, CYP1A1, and CYP1B1 levels were examined to uncover the mechanism of inhibition of cell migration by wedelolactone. RESULTS: We f …
Wedelolactone Acts as Proteasome Inhibitor in Breast Cancer Cells.
Nehybová T, Šmarda J, Daniel L, Stiborek M, Kanický V, Spasojevič I, Preisler J, Damborský J, Beneš P. Nehybová T, et al. Int J Mol Sci. 2017 Mar 29;18(4):729. doi: 10.3390/ijms18040729. Int J Mol Sci. 2017. PMID: 28353647 Free PMC article.
Wedelolactone is a multi-target natural plant coumestan exhibiting cytotoxicity towards cancer cells. ...Inhibition of proteasome by wedelolactone was independent on its ability to induce reactive oxygen species production by redox cycling with copper ions, suggesti …
Wedelolactone is a multi-target natural plant coumestan exhibiting cytotoxicity towards cancer cells. ...Inhibition of proteasome by …
Wedelolactone alleviates cholestatic liver injury by regulating FXR-bile acid-NF-kappaB/NRF2 axis to reduce bile acid accumulation and its subsequent inflammation and oxidative stress.
Wang MQ, Zhang KH, Liu FL, Zhou R, Zeng Y, Chen AL, Yu Y, Xia Q, Zhu CC, Lin CZ. Wang MQ, et al. Phytomedicine. 2024 Jan;122:155124. doi: 10.1016/j.phymed.2023.155124. Epub 2023 Sep 29. Phytomedicine. 2024. PMID: 38014837
BACKGROUND: Cholestatic liver diseases (CLD) comprise a variety of disorders of bile formation, which causes chronic exposure to bile acid (BA) in the liver generally and results in hepatotoxicity and progressive hepatobiliary injury. Wedelolactone (7-methoxy-5, 11, 12-tri …
BACKGROUND: Cholestatic liver diseases (CLD) comprise a variety of disorders of bile formation, which causes chronic exposure to bile acid ( …
Wedelolactone inhibits osteoclastogenesis but enhances osteoblastogenesis through altering different semaphorins production.
Deng X, Liang LN, Zhu D, Zheng LP, Yu JH, Meng XL, Zhao YN, Sun XX, Pan TW, Liu YQ. Deng X, et al. Int Immunopharmacol. 2018 Jul;60:41-49. doi: 10.1016/j.intimp.2018.04.037. Epub 2018 Apr 24. Int Immunopharmacol. 2018. PMID: 29702282
Wedelolactone combined with Sema4D antibody inhibited the formation of Sema4D-Plexin B1 complex. In co-culture of BMSC with RAW264.7 cells, Sema7A antibody, similar with Sema 3A antibody, reversed wedelolactone-enhanced ALP activity and mineralization level, but pro …
Wedelolactone combined with Sema4D antibody inhibited the formation of Sema4D-Plexin B1 complex. In co-culture of BMSC with RAW264.7 …
Wedelolactone from Vietnamese Eclipta prostrata (L) L. Protected Zymosan-induced shock in Mice.
Cuong TT, Diem GH, Doan TT, Huy NQ, Phuong N, Hung HT. Cuong TT, et al. Iran J Pharm Res. 2018 Spring;17(2):653-660. Iran J Pharm Res. 2018. PMID: 29881422 Free PMC article.
Wedelolactone is known to have biological activities such as anti-inflammation hepatitis, anti-hepatotoxic activity, and trypsin inhibitory effect. ...Collectively, these data indicated that wedelolactone reduced zymosan-induced inflammatory responses. Moreover, in- …
Wedelolactone is known to have biological activities such as anti-inflammation hepatitis, anti-hepatotoxic activity, and trypsin inhi …
236 results

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