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    Results: 1 to 20 of 49

    1.

    Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus.

    Hamilton G, Killick R; The Genetic and Environmental Risk for Alzheimer's disease (GERAD1) Consortium; Translational Genomics Research Institute (TGen) Consortium, Lambert JC, Amouyel P; European Alzheimer Disease Initiative (EADI), Carrasquillo MM, Pankratz VS, Graff-Radford NR, Dickson DW, Petersen RC, Younkin SG, Powell JF, Wade-Martins R.

    Neurobiol Aging. 2012 Mar 8. [Epub ahead of print]

    PMID:
    22405046
    [PubMed - as supplied by publisher]
    2.

    A novel method for autophagy detection in primary cells: Impaired levels of macroautophagy in immunosenescent T cells.

    Phadwal K, Alegre-Abarrategui J, Watson AS, Pike L, Anbalagan S, Hammond EM, Wade-Martins R, McMichael A, Klenerman P, Simon AK.

    Autophagy. 2012 Apr 1;8(4). [Epub ahead of print]

    PMID:
    22302009
    [PubMed - as supplied by publisher]
    Free Article
    3.

    Combining M-FISH and Quantum Dot technology for fast chromosomal assignment of transgenic insertions.

    Yusuf M, Bauer DL, Lipinski DM, MacLaren RE, Wade-Martins R, Mir KU, Volpi EV.

    BMC Biotechnol. 2011 Dec 13;11:121.

    PMID:
    22165957
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    4.

    Episomal transgene expression in pluripotent stem cells.

    Lufino MM, Popplestone AR, Cowley SA, Edser PA, James WS, Wade-Martins R.

    Methods Mol Biol. 2011;767:369-87.

    PMID:
    21822889
    [PubMed - indexed for MEDLINE]
    5.

    RNAi-mediated knockdown of HMG CoA reductase enhances gene expression from physiologically regulated low-density lipoprotein receptor therapeutic vectors in vivo.

    Hibbitt O, Agkatsev S, Owen C, Cioroch M, Seymour L, Channon K, Wade-Martins R.

    Gene Ther. 2012 Apr;19(4):463-7. doi: 10.1038/gt.2011.103. Epub 2011 Jul 28.

    PMID:
    21796214
    [PubMed - in process]
    6.

    A BACwards glance at neurodegeneration: molecular insights into disease from LRRK2, SNCA and MAPT BAC-transgenic mice.

    Johnson SJ, Wade-Martins R.

    Biochem Soc Trans. 2011 Aug;39(4):862-7. Review.

    PMID:
    21787314
    [PubMed - indexed for MEDLINE]
    7.

    Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family.

    Anwar S, Peters O, Millership S, Ninkina N, Doig N, Connor-Robson N, Threlfell S, Kooner G, Deacon RM, Bannerman DM, Bolam JP, Chandra SS, Cragg SJ, Wade-Martins R, Buchman VL.

    J Neurosci. 2011 May 18;31(20):7264-74.

    PMID:
    21593311
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    8.

    Infectious delivery and long-term persistence of transgene expression in the brain by a 135-kb iBAC-FXN genomic DNA expression vector.

    Gimenez-Cassina A, Wade-Martins R, Gomez-Sebastian S, Corona JC, Lim F, Diaz-Nido J.

    Gene Ther. 2011 Oct;18(10):1015-9. doi: 10.1038/gt.2011.45. Epub 2011 Apr 14.

    PMID:
    21490681
    [PubMed - indexed for MEDLINE]
    9.

    High capacity extrachromosomal gene expression vectors.

    Hibbitt O, Wade-Martins R.

    Methods Mol Biol. 2011;738:19-40.

    PMID:
    21431717
    [PubMed - indexed for MEDLINE]
    10.

    Developing extrachromosomal gene expression vector technologies: an overview.

    Wade-Martins R.

    Methods Mol Biol. 2011;738:1-17. Review.

    PMID:
    21431716
    [PubMed - indexed for MEDLINE]
    11.

    Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation.

    Shipton OA, Leitz JR, Dworzak J, Acton CE, Tunbridge EM, Denk F, Dawson HN, Vitek MP, Wade-Martins R, Paulsen O, Vargas-Caballero M.

    J Neurosci. 2011 Feb 2;31(5):1688-92.

    PMID:
    21289177
    [PubMed - indexed for MEDLINE]
    Free Article
    12.

    α-Synuclein and dopamine at the crossroads of Parkinson's disease.

    Venda LL, Cragg SJ, Buchman VL, Wade-Martins R.

    Trends Neurosci. 2010 Dec;33(12):559-68. Epub 2010 Oct 18. Review.

    PMID:
    20961626
    [PubMed - indexed for MEDLINE]
    13.

    A high-throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2-deficient tumors.

    Evers B, Schut E, van der Burg E, Braumuller TM, Egan DA, Holstege H, Edser P, Adams DJ, Wade-Martins R, Bouwman P, Jonkers J.

    Clin Cancer Res. 2010 Jan 1;16(1):99-108. Epub 2009 Dec 15.

    PMID:
    20008842
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    14.

    Long-term physiologically regulated expression of the low-density lipoprotein receptor in vivo using genomic DNA mini-gene constructs.

    Hibbitt OC, McNeil E, Lufino MM, Seymour L, Channon K, Wade-Martins R.

    Mol Ther. 2010 Feb;18(2):317-26. Epub 2009 Oct 27.

    PMID:
    19861949
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    15.

    Parkinson disease, LRRK2 and the endocytic-autophagic pathway.

    Alegre-Abarrategui J, Wade-Martins R.

    Autophagy. 2009 Nov;5(8):1208-10. Epub 2009 Nov 24.

    PMID:
    19770575
    [PubMed - indexed for MEDLINE]
    Free Article
    16.

    LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model.

    Alegre-Abarrategui J, Christian H, Lufino MM, Mutihac R, Venda LL, Ansorge O, Wade-Martins R.

    Hum Mol Genet. 2009 Nov 1;18(21):4022-34. Epub 2009 Jul 29.

    PMID:
    19640926
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    17.

    Quantitative characterization of cell transduction by HSV-1 amplicons using flow cytometry and real-time PCR.

    El-Sherbini YM, Stevenson MM, Seymour LW, Wade-Martins R.

    J Virol Methods. 2009 Aug;159(2):160-6. Epub 2009 Mar 26.

    PMID:
    19490970
    [PubMed - indexed for MEDLINE]
    18.

    Physiological transgene regulation and functional complementation of a neurological disease gene deficiency in neurons.

    Peruzzi PP, Lawler SE, Senior SL, Dmitrieva N, Edser PA, Gianni D, Chiocca EA, Wade-Martins R.

    Mol Ther. 2009 Sep;17(9):1517-26. Epub 2009 Apr 7.

    PMID:
    19352323
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    19.

    A common variant associated with dyslexia reduces expression of the KIAA0319 gene.

    Dennis MY, Paracchini S, Scerri TS, Prokunina-Olsson L, Knight JC, Wade-Martins R, Coggill P, Beck S, Green ED, Monaco AP.

    PLoS Genet. 2009 Mar;5(3):e1000436. Epub 2009 Mar 27.

    PMID:
    19325871
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    20.

    The effect of alpha-synuclein knockdown on MPP+ toxicity in models of human neurons.

    Fountaine TM, Venda LL, Warrick N, Christian HC, Brundin P, Channon KM, Wade-Martins R.

    Eur J Neurosci. 2008 Dec;28(12):2459-73. Epub 2008 Nov 21.

    PMID:
    19032594
    [PubMed - indexed for MEDLINE]
    Free PMC Article

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