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VRK2 gene expression in schizophrenia, bipolar disorder and healthy controls.
Tesli M, Wirgenes KV, Hughes T, Bettella F, Athanasiu L, Hoseth ES, Nerhus M, Lagerberg TV, Steen NE, Agartz I, Melle I, Dieset I, Djurovic S, Andreassen OA. Tesli M, et al. Br J Psychiatry. 2016 Aug;209(2):114-20. doi: 10.1192/bjp.bp.115.161950. Epub 2016 Mar 3. Br J Psychiatry. 2016. PMID: 26941264
BACKGROUND: Common variants in the Vaccinia-related kinase 2 (VRK2) gene have been associated with schizophrenia, but the relevance of its encoded protein VRK2 in the disorder remains unclear. ...These results suggest that reduced VRK2 mRNA levels are …
BACKGROUND: Common variants in the Vaccinia-related kinase 2 (VRK2) gene have been associated with schizophrenia, but the rele …
VRK2, a Candidate Gene for Psychiatric and Neurological Disorders.
Li M, Yue W. Li M, et al. Mol Neuropsychiatry. 2018 Dec;4(3):119-133. doi: 10.1159/000493941. Epub 2018 Nov 7. Mol Neuropsychiatry. 2018. PMID: 30643786 Free PMC article. Review.
Recent large-scale genetic approaches, such as genome-wide association studies, have identified multiple genetic variations that contribute to the risk of mental illnesses, among which single nucleotide polymorphisms (SNPs) within or near the vaccinia related kinase 2 (VRK2 …
Recent large-scale genetic approaches, such as genome-wide association studies, have identified multiple genetic variations that contribute …
Vrk2 deficiency elicits aggressive behavior in female zebrafish.
Umeda R, Teranishi H, Hada K, Shimizu N, Shiraishi H, Urushibata H, Lai S, Shide M, Carrasco Apolinario ME, Higa R, Shikano K, Shin T, Mimata H, Hikida T, Hanada T, Hanada R. Umeda R, et al. Genes Cells. 2022 Apr;27(4):254-265. doi: 10.1111/gtc.12924. Epub 2022 Feb 15. Genes Cells. 2022. PMID: 35094457 Free article.
Many genome-wide association studies (GWASs) have reported that VRK2 is a potential candidate molecule for neuropsychiatric diseases such as schizophrenia in humans. ...In this study, we evaluated vrk2-deficient (vrk2(-/-) ) zebrafish and found that …
Many genome-wide association studies (GWASs) have reported that VRK2 is a potential candidate molecule for neuropsychiatric diseases …
Further evidence of VRK2 rs2312147 associated with schizophrenia.
Chang H, Zhang C, Xiao X, Pu X, Liu Z, Wu L, Li M. Chang H, et al. World J Biol Psychiatry. 2016 Sep;17(6):457-66. doi: 10.1080/15622975.2016.1200746. Epub 2016 Jul 6. World J Biol Psychiatry. 2016. PMID: 27382989
OBJECTIVES: Previous genome-wide association studies (GWAS) have reported that rs2312147 near the VRK2 gene was significantly associated with schizophrenia in populations of European descent, but negative results have also been observed. METHODS: To perform a system …
OBJECTIVES: Previous genome-wide association studies (GWAS) have reported that rs2312147 near the VRK2 gene was significantly associa …
Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates.
Dashti HS, Jones SE, Wood AR, Lane JM, van Hees VT, Wang H, Rhodes JA, Song Y, Patel K, Anderson SG, Beaumont RN, Bechtold DA, Bowden J, Cade BE, Garaulet M, Kyle SD, Little MA, Loudon AS, Luik AI, Scheer FAJL, Spiegelhalder K, Tyrrell J, Gottlieb DJ, Tiemeier H, Ray DW, Purcell SM, Frayling TM, Redline S, Lawlor DA, Rutter MK, Weedon MN, Saxena R. Dashti HS, et al. Nat Commun. 2019 Mar 7;10(1):1100. doi: 10.1038/s41467-019-08917-4. Nat Commun. 2019. PMID: 30846698 Free PMC article.

Through genome-wide association analysis in 446,118 adults of European ancestry from the UK Biobank, we identify 78 loci for self-reported habitual sleep duration (p < 5 10(-8); 43 loci at p < 6 10(-9)). Replication is observed for PAX8, VRK2, and FBXL12/UBL5/PIN1 lo

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Through genome-wide association analysis in 446,118 adults of European ancestry from the UK Biobank, we identify 78 loci for self-reported h …
Vaccinia Related Kinase 2 (VRK2) expression in neurological disorders: schizophrenia, epilepsy and multiple sclerosis.
Azimi T, Ghafouri-Fard S, Davood Omrani M, Mazdeh M, Arsang-Jang S, Sayad A, Taheri M. Azimi T, et al. Mult Scler Relat Disord. 2018 Jan;19:15-19. doi: 10.1016/j.msard.2017.10.017. Epub 2017 Oct 25. Mult Scler Relat Disord. 2018. PMID: 29100046
In the present case-control study we compared the VRK2 gene expression in peripheral blood samples from SCZ, epilepsy and MS patients with normal subjects. ...The results demonstrated significant down-regulation of VRK2 gene in SCZ (P<0.0001), epilepsy (P=0.008) …
In the present case-control study we compared the VRK2 gene expression in peripheral blood samples from SCZ, epilepsy and MS patients …
Association of the VRK2 gene rs3732136 polymorphism with schizophrenia in a Northwest Chinese Han population.
Zhang B, Gao CY, Zhang HB, Yang B, Yin JF, Wei SG, Zhu YS, Jia XN, Li SB. Zhang B, et al. Genet Mol Res. 2015 Aug 14;14(3):9404-11. doi: 10.4238/2015.August.14.4. Genet Mol Res. 2015. PMID: 26345874 Free article.
Previous studies have found that the vaccinia related kinase 2 gene (VRK2) polymorphism was associated with schizophrenia (SCZ) in the worldwide population. This association was further supported by VRK2 mRNA expression patterns and brain structure variations …
Previous studies have found that the vaccinia related kinase 2 gene (VRK2) polymorphism was associated with schizophrenia (SCZ …
Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility.
Li M, Wang Y, Zheng XB, Ikeda M, Iwata N, Luo XJ, Chong SA, Lee J, Rietschel M, Zhang F, Müller-Myhsok B, Cichon S, Weinberger DR, Mattheisen M, Schulze TG, Martin NG, Mitchell PB, Schofield PR, Liu JJ, Su B; MooDS Consortium. Li M, et al. Schizophr Res. 2012 Dec;142(1-3):200-5. doi: 10.1016/j.schres.2012.10.008. Epub 2012 Oct 25. Schizophr Res. 2012. PMID: 23102693
Recent genome-wide association studies have reported a set of schizophrenia susceptibility genes, but many of them await further replications in additional samples. ...Rs2312147 is also associated with brain structure in healthy subjects, including the total brain volume a …
Recent genome-wide association studies have reported a set of schizophrenia susceptibility genes, but many of them await further repl …
Evaluation of the relationship between VRK2, rs4380187 polymorphisms, and genetic susceptibility to schizophrenia in the Chinese Han population.
Liu X, Han T, Xie H, Fu Z, Yao Q, Lin Z, Zhu H, Zhan D. Liu X, et al. J Gene Med. 2021 Mar;23(3):e3313. doi: 10.1002/jgm.3313. Epub 2021 Jan 31. J Gene Med. 2021. PMID: 33522046
VRK2 is considered to be related to the pathogenesis of schizophrenia. In this study, we analyzed the correlation between VRK2, rs4380187 single-nucleotide polymorphism (SNP), and schizophrenia. ...
VRK2 is considered to be related to the pathogenesis of schizophrenia. In this study, we analyzed the correlation between V …
Effects of VRK2 (rs2312147) on white matter connectivity in patients with schizophrenia.
Sohn H, Kim B, Kim KH, Kim MK, Choi TK, Lee SH. Sohn H, et al. PLoS One. 2014 Jul 31;9(7):e103519. doi: 10.1371/journal.pone.0103519. eCollection 2014. PLoS One. 2014. PMID: 25079070 Free PMC article.
Recent genome-wide association studies of schizophrenia reported a novel risk variant, rs2312147 at vaccinia-related kinase 2 gene (VRK2), in multiple Asian and European samples. ...Brain magnetic resonance scans for gray matter (GM) and white matter (WM) analysis, …
Recent genome-wide association studies of schizophrenia reported a novel risk variant, rs2312147 at vaccinia-related kinase 2 gene ( …
24 results