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Items: 1 to 20 of 327


Polymorphisms in the Pattern Recognition Receptor Mincle Gene (CLEC4E) and Association with Tuberculosis.

Bowker N, Salie M, Schurz H, van Helden PD, Kinnear CJ, Hoal EG, Möller M.

Lung. 2016 Jun 30. [Epub ahead of print]


Antigen-Specific IP-10 Release Is a Sensitive Biomarker of Mycobacterium bovis Infection in Cattle.

Parsons SD, McGill K, Doyle MB, Goosen WJ, van Helden PD, Gormley E.

PLoS One. 2016 May 11;11(5):e0155440. doi: 10.1371/journal.pone.0155440. eCollection 2016.


Mapping of Mycobacterium tuberculosis Complex Genetic Diversity Profiles in Tanzania and Other African Countries.

Mbugi EV, Katale BZ, Streicher EM, Keyyu JD, Kendall SL, Dockrell HM, Michel AL, Rweyemamu MM, Warren RM, Matee MI, van Helden PD, Couvin D, Rastogi N.

PLoS One. 2016 May 5;11(5):e0154571. doi: 10.1371/journal.pone.0154571. eCollection 2016.


Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs and symptoms suggestive of TB.

Chegou NN, Sutherland JS, Malherbe S, Crampin AC, Corstjens PL, Geluk A, Mayanja-Kizza H, Loxton AG, van der Spuy G, Stanley K, Kotzé LA, van der Vyver M, Rosenkrands I, Kidd M, van Helden PD, Dockrell HM, Ottenhoff TH, Kaufmann SH, Walzl G; AE-TBC consortium.

Thorax. 2016 May 4. pii: thoraxjnl-2015-207999. doi: 10.1136/thoraxjnl-2015-207999. [Epub ahead of print]


Optimizing the use of cadavers by integrating pathology during anatomy dissection.

Geldenhuys EM, Burger EH, van Helden PD, Mole CG, Kotzé SH.

Anat Sci Educ. 2016 May 3. doi: 10.1002/ase.1617. [Epub ahead of print]


The stability of plasma IP-10 enhances its utility for the diagnosis of Mycobacterium bovis infection in African buffaloes (Syncerus caffer).

Goosen WJ, van Helden PD, Warren RM, Miller MA, Parsons SD.

Vet Immunol Immunopathol. 2016 May;173:17-20. doi: 10.1016/j.vetimm.2016.03.013. Epub 2016 Mar 25.


Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy.

Honeyborne I, McHugh TD, Kuittinen I, Cichonska A, Evangelopoulos D, Ronacher K, van Helden PD, Gillespie SH, Fernandez-Reyes D, Walzl G, Rousu J, Butcher PD, Waddell SJ.

BMC Med. 2016 Apr 7;14(1):68. doi: 10.1186/s12916-016-0609-3.


The plasmid-mediated evolution of the mycobacterial ESX (Type VII) secretion systems.

Newton-Foot M, Warren RM, Sampson SL, van Helden PD, Gey van Pittius NC.

BMC Evol Biol. 2016 Mar 15;16:62. doi: 10.1186/s12862-016-0631-2.


Translational Research for Tuberculosis Elimination: Priorities, Challenges, and Actions.

Lienhardt C, Lönnroth K, Menzies D, Balasegaram M, Chakaya J, Cobelens F, Cohn J, Denkinger CM, Evans TG, Källenius G, Kaplan G, Kumar AM, Matthiessen L, Mgone CS, Mizrahi V, Mukadi YD, Nguyen VN, Nordström A, Sizemore CF, Spigelman M, Squire SB, Swaminathan S, Van Helden PD, Zumla A, Weyer K, Weil D, Raviglione M.

PLoS Med. 2016 Mar 2;13(3):e1001965. doi: 10.1371/journal.pmed.1001965. eCollection 2016 Mar. Review. No abstract available.


Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages.

Phelan JE, Coll F, Bergval I, Anthony RM, Warren R, Sampson SL, Gey van Pittius NC, Glynn JR, Crampin AC, Alves A, Bessa TB, Campino S, Dheda K, Grandjean L, Hasan R, Hasan Z, Miranda A, Moore D, Panaiotov S, Perdigao J, Portugal I, Sheen P, de Oliveira Sousa E, Streicher EM, van Helden PD, Viveiros M, Hibberd ML, Pain A, McNerney R, Clark TG.

BMC Genomics. 2016 Feb 29;17:151. doi: 10.1186/s12864-016-2467-y.


The prevalence of antibodies to Toxoplasma gondii in sheep in the Western Cape, South Africa.

Hammond-Aryee K, Van Helden LS, Van Helden PD.

Onderstepoort J Vet Res. 2015 Nov 3;82(1):993. doi: 10.4102/ojvr.v82i1.993.


Glutamate Dehydrogenase Is Required by Mycobacterium bovis BCG for Resistance to Cellular Stress.

Gallant JL, Viljoen AJ, van Helden PD, Wiid IJ.

PLoS One. 2016 Jan 29;11(1):e0147706. doi: 10.1371/journal.pone.0147706. eCollection 2016.


The Risk of Tuberculosis Reinfection Soon after Cure of a First Disease Episode Is Extremely High in a Hyperendemic Community.

Uys P, Brand H, Warren R, van der Spuy G, Hoal EG, van Helden PD.

PLoS One. 2015 Dec 9;10(12):e0144487. doi: 10.1371/journal.pone.0144487. eCollection 2015.


Effect of milk fermentation by kefir grains and selected single strains of lactic acid bacteria on the survival of Mycobacterium bovis BCG.

Macuamule CL, Wiid IJ, van Helden PD, Tanner M, Witthuhn RC.

Int J Food Microbiol. 2016 Jan 18;217:170-6. doi: 10.1016/j.ijfoodmicro.2015.10.024. Epub 2015 Oct 25.


Whole genome sequence analysis of Mycobacterium suricattae.

Dippenaar A, Parsons SD, Sampson SL, van der Merwe RG, Drewe JA, Abdallah AM, Siame KK, Gey van Pittius NC, van Helden PD, Pain A, Warren RM.

Tuberculosis (Edinb). 2015 Dec;95(6):682-8. doi: 10.1016/ Epub 2015 Oct 13.


Development of a Gene Expression Assay for the Diagnosis of Mycobacterium bovis Infection in African Lions (Panthera leo).

Olivier TT, Viljoen IM, Hofmeyr J, Hausler GA, Goosen WJ, Tordiffe AS, Buss P, Loxton AG, Warren RM, Miller MA, van Helden PD, Parsons SD.

Transbound Emerg Dis. 2015 Oct 30. doi: 10.1111/tbed.12436. [Epub ahead of print]


Whole genome sequencing reveals genomic heterogeneity and antibiotic purification in Mycobacterium tuberculosis isolates.

Black PA, de Vos M, Louw GE, van der Merwe RG, Dippenaar A, Streicher EM, Abdallah AM, Sampson SL, Victor TC, Dolby T, Simpson JA, van Helden PD, Warren RM, Pain A.

BMC Genomics. 2015 Oct 24;16:857. doi: 10.1186/s12864-015-2067-2.


Efflux pump inhibitors: targeting mycobacterial efflux systems to enhance TB therapy.

Pule CM, Sampson SL, Warren RM, Black PA, van Helden PD, Victor TC, Louw GE.

J Antimicrob Chemother. 2016 Jan;71(1):17-26. doi: 10.1093/jac/dkv316. Epub 2015 Oct 15. Review.


A Subgroup of Latently Mycobacterium tuberculosis Infected Individuals Is Characterized by Consistently Elevated IgA Responses to Several Mycobacterial Antigens.

Baumann R, Kaempfer S, Chegou NN, Oehlmann W, Spallek R, Loxton AG, van Helden PD, Black GF, Singh M, Walzl G.

Mediators Inflamm. 2015;2015:364758. doi: 10.1155/2015/364758. Epub 2015 Aug 10.


Molecular Epidemiological Interpretation of the Epidemic of Extensively Drug-Resistant Tuberculosis in South Africa.

Streicher EM, Sampson SL, Dheda K, Dolby T, Simpson JA, Victor TC, Gey van Pittius NC, van Helden PD, Warren RM.

J Clin Microbiol. 2015 Nov;53(11):3650-3. doi: 10.1128/JCM.01414-15. Epub 2015 Sep 2.

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