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Disease Control in Wildlife: Evaluating a Test and Cull Programme for Bovine Tuberculosis in African Buffalo.

le Roex N, Cooper D, van Helden PD, Hoal EG, Jolles AE.

Transbound Emerg Dis. 2015 Jan 24. doi: 10.1111/tbed.12329. [Epub ahead of print]


A novel inhibitor of gyrase B is a potent drug candidate for treatment of tuberculosis and nontuberculosis mycobacterial infections.

Locher CP, Jones SM, Hanzelka BL, Perola E, Shoen CM, Cynamon MH, Ngwane AH, Wiid IJ, van Helden PD, Betoudji F, Nuermberger EL, Thomson JA.

Antimicrob Agents Chemother. 2015 Mar;59(3):1455-65. doi: 10.1128/AAC.04347-14. Epub 2014 Dec 22.


Genetic diversity of Mycobacterium tuberculosis isolated from tuberculosis patients in the Serengeti ecosystem in Tanzania.

Mbugi EV, Katale BZ, Siame KK, Keyyu JD, Kendall SL, Dockrell HM, Streicher EM, Michel AL, Rweyemamu MM, Warren RM, Matee MI, van Helden PD.

Tuberculosis (Edinb). 2015 Mar;95(2):170-8. doi: 10.1016/ Epub 2014 Nov 29.


The evaluation of candidate biomarkers of cell-mediated immunity for the diagnosis of Mycobacterium bovis infection in African buffaloes (Syncerus caffer).

Goosen WJ, Cooper D, Warren RM, Miller MA, van Helden PD, Parsons SD.

Vet Immunol Immunopathol. 2014 Dec 15;162(3-4):198-202. doi: 10.1016/j.vetimm.2014.10.008. Epub 2014 Oct 26.


Using multi-way admixture mapping to elucidate TB susceptibility in the South African Coloured population.

Daya M, van der Merwe L, Gignoux CR, van Helden PD, Möller M, Hoal EG.

BMC Genomics. 2014 Nov 25;15:1021. doi: 10.1186/1471-2164-15-1021.


Positive selection of deleterious alleles through interaction with a sex-ratio suppressor gene in African Buffalo: a plausible new mechanism for a high frequency anomaly.

van Hooft P, Greyling BJ, Getz WM, van Helden PD, Zwaan BJ, Bastos AD.

PLoS One. 2014 Nov 5;9(11):e111778. doi: 10.1371/journal.pone.0111778. eCollection 2014.


Rapid diagnosis of pediatric mycobacterial lymphadenitis using fine needle aspiration biopsy.

Coetzee L, Nicol MP, Jacobson R, Schubert PT, van Helden PD, Warren RM, Wright CA.

Pediatr Infect Dis J. 2014 Sep;33(9):893-6. doi: 10.1097/INF.0000000000000312.


Impact of nonlinear interactions of pharmacokinetics and MICs on sputum bacillary kill rates as a marker of sterilizing effect in tuberculosis.

Chigutsa E, Pasipanodya JG, Visser ME, van Helden PD, Smith PJ, Sirgel FA, Gumbo T, McIlleron H.

Antimicrob Agents Chemother. 2015 Jan;59(1):38-45. doi: 10.1128/AAC.03931-14. Epub 2014 Oct 13.


Rapid sequencing of the Mycobacterium tuberculosis pncA gene for detection of pyrazinamide susceptibility.

Streicher EM, Maharaj K, York T, Van Heerden C, Barnard M, Diacon A, Mendel CM, Bosman ME, Hepple JA, Pym AS, Warren RM, van Helden PD.

J Clin Microbiol. 2014 Nov;52(11):4056-7. doi: 10.1128/JCM.02438-14. Epub 2014 Aug 27.


Serologic diagnosis of tuberculosis by combining Ig classes against selected mycobacterial targets.

Baumann R, Kaempfer S, Chegou NN, Oehlmann W, Loxton AG, Kaufmann SH, van Helden PD, Black GF, Singh M, Walzl G.

J Infect. 2014 Dec;69(6):581-9. doi: 10.1016/j.jinf.2014.05.014. Epub 2014 Jun 23.


The role of ancestry in TB susceptibility of an admixed South African population.

Daya M, van der Merwe L, van Helden PD, Möller M, Hoal EG.

Tuberculosis (Edinb). 2014 Jul;94(4):413-20. doi: 10.1016/ Epub 2014 Apr 13.


The pyrazinamide susceptibility breakpoint above which combination therapy fails.

Gumbo T, Chigutsa E, Pasipanodya J, Visser M, van Helden PD, Sirgel FA, McIlleron H.

J Antimicrob Chemother. 2014 Sep;69(9):2420-5. doi: 10.1093/jac/dku136. Epub 2014 May 12.


Agreement between assays of cell-mediated immunity utilizing Mycobacterium bovis-specific antigens for the diagnosis of tuberculosis in African buffaloes (Syncerus caffer).

Goosen WJ, Miller MA, Chegou NN, Cooper D, Warren RM, van Helden PD, Parsons SD.

Vet Immunol Immunopathol. 2014 Jul 15;160(1-2):133-8. doi: 10.1016/j.vetimm.2014.03.015. Epub 2014 Apr 4.


Phage-based detection of bacterial pathogens.

van der Merwe RG, van Helden PD, Warren RM, Sampson SL, Gey van Pittius NC.

Analyst. 2014 Jun 7;139(11):2617-26. doi: 10.1039/c4an00208c.


The temporal dynamics of relapse and reinfection tuberculosis after successful treatment: a retrospective cohort study.

Marx FM, Dunbar R, Enarson DA, Williams BG, Warren RM, van der Spuy GD, van Helden PD, Beyers N.

Clin Infect Dis. 2014 Jun;58(12):1676-83. doi: 10.1093/cid/ciu186. Epub 2014 Mar 18.


Energy metabolism and drug efflux in Mycobacterium tuberculosis.

Black PA, Warren RM, Louw GE, van Helden PD, Victor TC, Kana BD.

Antimicrob Agents Chemother. 2014 May;58(5):2491-503. doi: 10.1128/AAC.02293-13. Epub 2014 Mar 10.


Moxifloxacin retains antimycobacterial activity in the presence of gyrA mutations.

McGrath M, Gey van Pittius NC, Sirgel FA, Van Helden PD, Warren RM.

Antimicrob Agents Chemother. 2014 May;58(5):2912-5. doi: 10.1128/AAC.02583-13. Epub 2014 Feb 10.


Mycobacterium bovis BCG infection severely delays Trichuris muris expulsion and co-infection suppresses immune responsiveness to both pathogens.

Nel HJ, du Plessis N, Kleynhans L, Loxton AG, van Helden PD, Walzl G.

BMC Microbiol. 2014 Jan 17;14:9. doi: 10.1186/1471-2180-14-9.


Evaluation of the AID TB resistance line probe assay for rapid detection of genetic alterations associated with drug resistance in Mycobacterium tuberculosis strains.

Ritter C, Lucke K, Sirgel FA, Warren RW, van Helden PD, Böttger EC, Bloemberg GV.

J Clin Microbiol. 2014 Mar;52(3):940-6. doi: 10.1128/JCM.02597-13. Epub 2014 Jan 8.


A panel of ancestry informative markers for the complex five-way admixed South African coloured population.

Daya M, van der Merwe L, Galal U, Möller M, Salie M, Chimusa ER, Galanter JM, van Helden PD, Henn BM, Gignoux CR, Hoal E.

PLoS One. 2013 Dec 20;8(12):e82224. doi: 10.1371/journal.pone.0082224. eCollection 2013.

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