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Results: 1 to 20 of 66

1.

A critical appraisal of the process of regulatory implementation of novel in vivo and in vitro methods for chemical hazard and risk assessment.

Piersma AH, Ezendam J, Luijten M, Muller JJ, Rorije E, van der Ven LT, van Benthem J.

Crit Rev Toxicol. 2014 Jul 24:1-19. [Epub ahead of print]

PMID:
25058877
[PubMed - as supplied by publisher]
2.

Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment.

Johnson GE, Soeteman-Hernández LG, Gollapudi BB, Bodger OG, Dearfield KL, Heflich RH, Hixon JG, Lovell DP, Macgregor JT, Pottenger LH, Thompson CM, Abraham L, Thybaud V, Tanir JY, Zeiger E, van Benthem J, White PA.

Environ Mol Mutagen. 2014 May 6. doi: 10.1002/em.21870. [Epub ahead of print]

PMID:
24801602
[PubMed - as supplied by publisher]
3.

A mode-of-action approach for the identification of genotoxic carcinogens.

Hernández LG, van Benthem J, Johnson GE.

PLoS One. 2013 May 13;8(5):e64532. doi: 10.1371/journal.pone.0064532. Print 2013.

PMID:
23675539
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

The development of adverse outcome pathways for mutagenic effects for the organization for economic co-operation and development.

Yauk CL, Bishop J, Dearfield KL, Douglas GR, Hales BF, Luijten M, O'Brien JM, Robaire B, Sram R, van Benthem J, Wade MG, White PA, Marchetti F.

Environ Mol Mutagen. 2013 Mar;54(2):79-81. doi: 10.1002/em.21757. Epub 2013 Jan 28. No abstract available.

PMID:
23355186
[PubMed - indexed for MEDLINE]
5.

Detection of genotoxic and non-genotoxic carcinogens in Xpc(-/-)p53(+/-) mice.

Melis JP, Speksnijder EN, Kuiper RV, Salvatori DC, Schaap MM, Maas S, Robinson J, Verhoef A, van Benthem J, Luijten M, van Steeg H.

Toxicol Appl Pharmacol. 2013 Jan 15;266(2):289-97. doi: 10.1016/j.taap.2012.11.004. Epub 2012 Nov 12.

PMID:
23153559
[PubMed - indexed for MEDLINE]
6.

Quantitative approaches for assessing dose-response relationships in genetic toxicology studies.

Gollapudi BB, Johnson GE, Hernandez LG, Pottenger LH, Dearfield KL, Jeffrey AM, Julien E, Kim JH, Lovell DP, Macgregor JT, Moore MM, van Benthem J, White PA, Zeiger E, Thybaud V.

Environ Mol Mutagen. 2013 Jan;54(1):8-18. doi: 10.1002/em.21727. Epub 2012 Sep 18.

PMID:
22987251
[PubMed - indexed for MEDLINE]
7.

Proliferating primary hepatocytes from the pUR288 lacZ plasmid mouse are valuable tools for genotoxicity assessment in vitro.

Zwart EP, Schaap MM, van den Dungen MW, Braakhuis HM, White PA, van Steeg H, van Benthem J, Luijten M.

Environ Mol Mutagen. 2012 Jun;53(5):1-8. doi: 10.1002/em.21700. Epub 2012 May 23.

PMID:
22619112
[PubMed - indexed for MEDLINE]
8.

Reproductive toxicants have a threshold of adversity.

Piersma AH, Hernandez LG, van Benthem J, Muller JJ, van Leeuwen FX, Vermeire TG, van Raaij MT.

Crit Rev Toxicol. 2011 Jul;41(6):545-54. doi: 10.3109/10408444.2011.554794. Epub 2011 May 24. Review.

PMID:
21609253
[PubMed - indexed for MEDLINE]
9.

Hazardous compounds in tobacco smoke.

Talhout R, Schulz T, Florek E, van Benthem J, Wester P, Opperhuizen A.

Int J Environ Res Public Health. 2011 Feb;8(2):613-28. doi: 10.3390/ijerph8020613. Epub 2011 Feb 23. Review.

PMID:
21556207
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Can carcinogenic potency be predicted from in vivo genotoxicity data?: a meta-analysis of historical data.

Hernández LG, Slob W, van Steeg H, van Benthem J.

Environ Mol Mutagen. 2011 Aug;52(7):518-28. doi: 10.1002/em.20651. Epub 2011 May 3.

PMID:
21542028
[PubMed - indexed for MEDLINE]
11.

Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.

Adler S, Basketter D, Creton S, Pelkonen O, van Benthem J, Zuang V, Andersen KE, Angers-Loustau A, Aptula A, Bal-Price A, Benfenati E, Bernauer U, Bessems J, Bois FY, Boobis A, Brandon E, Bremer S, Broschard T, Casati S, Coecke S, Corvi R, Cronin M, Daston G, Dekant W, Felter S, Grignard E, Gundert-Remy U, Heinonen T, Kimber I, Kleinjans J, Komulainen H, Kreiling R, Kreysa J, Leite SB, Loizou G, Maxwell G, Mazzatorta P, Munn S, Pfuhler S, Phrakonkham P, Piersma A, Poth A, Prieto P, Repetto G, Rogiers V, Schoeters G, Schwarz M, Serafimova R, Tähti H, Testai E, van Delft J, van Loveren H, Vinken M, Worth A, Zaldivar JM.

Arch Toxicol. 2011 May;85(5):367-485. doi: 10.1007/s00204-011-0693-2. Epub 2011 May 1. Review.

PMID:
21533817
[PubMed - indexed for MEDLINE]
12.

In vitro genotoxicity test approaches with better predictivity: summary of an IWGT workshop.

Pfuhler S, Fellows M, van Benthem J, Corvi R, Curren R, Dearfield K, Fowler P, Frötschl R, Elhajouji A, Le Hégarat L, Kasamatsu T, Kojima H, Ouédraogo G, Scott A, Speit G.

Mutat Res. 2011 Aug 16;723(2):101-7. doi: 10.1016/j.mrgentox.2011.03.013. Epub 2011 Apr 5.

PMID:
21473931
[PubMed - indexed for MEDLINE]
13.

Finding maximal transcriptome differences between reprotoxic and non-reprotoxic phthalate responses in rat testis.

Yuan X, Jonker MJ, de Wilde J, Verhoef A, Wittink FR, van Benthem J, Bessems JG, Hakkert BC, Kuiper RV, van Steeg H, Breit TM, Luijten M.

J Appl Toxicol. 2011 Jul;31(5):421-30. doi: 10.1002/jat.1601. Epub 2010 Nov 9.

PMID:
21061450
[PubMed - indexed for MEDLINE]
14.

Follow-up actions from positive results of in vitro genetic toxicity testing.

Dearfield KL, Thybaud V, Cimino MC, Custer L, Czich A, Harvey JS, Hester S, Kim JH, Kirkland D, Levy DD, Lorge E, Moore MM, Ouédraogo-Arras G, Schuler M, Suter W, Sweder K, Tarlo K, van Benthem J, van Goethem F, Witt KL.

Environ Mol Mutagen. 2011 Apr;52(3):177-204. doi: 10.1002/em.20617. Epub 2010 Oct 20. Review.

PMID:
20963811
[PubMed - indexed for MEDLINE]
Free Article
15.

Evaluation of benzo(a)pyrene-induced gene mutations in male germ cells.

Verhofstad N, van Oostrom CT, Zwart E, Maas LM, van Benthem J, van Schooten FJ, van Steeg H, Godschalk RW.

Toxicol Sci. 2011 Jan;119(1):218-23. doi: 10.1093/toxsci/kfq325. Epub 2010 Oct 20.

PMID:
20961952
[PubMed - indexed for MEDLINE]
Free Article
16.

Strategies in case of positive in vivo results in genotoxicity testing.

Thybaud V, Macgregor JT, Müller L, Crebelli R, Dearfield K, Douglas G, Farmer PB, Gocke E, Hayashi M, Lovell DP, Lutz WK, Marzin D, Moore M, Nohmi T, Phillips DH, Van Benthem J.

Mutat Res. 2011 Aug 16;723(2):121-8. doi: 10.1016/j.mrgentox.2010.09.002. Epub 2010 Sep 17.

PMID:
20854927
[PubMed - indexed for MEDLINE]
17.

New and emerging technologies for genetic toxicity testing.

Lynch AM, Sasaki JC, Elespuru R, Jacobson-Kram D, Thybaud V, De Boeck M, Aardema MJ, Aubrecht J, Benz RD, Dertinger SD, Douglas GR, White PA, Escobar PA, Fornace A Jr, Honma M, Naven RT, Rusling JF, Schiestl RH, Walmsley RM, Yamamura E, van Benthem J, Kim JH.

Environ Mol Mutagen. 2011 Apr;52(3):205-23. doi: 10.1002/em.20614. Epub 2010 Aug 25. Review.

PMID:
20740635
[PubMed - indexed for MEDLINE]
18.

Genotoxicity evaluation of amorphous silica nanoparticles of different sizes using the micronucleus and the plasmid lacZ gene mutation assay.

Park MV, Verharen HW, Zwart E, Hernandez LG, van Benthem J, Elsaesser A, Barnes C, McKerr G, Howard CV, Salvati A, Lynch I, Dawson KA, de Jong WH.

Nanotoxicology. 2011 Jun;5(2):168-81. doi: 10.3109/17435390.2010.506016. Epub 2010 Aug 24.

PMID:
20735203
[PubMed - indexed for MEDLINE]
19.

Benzo(a)pyrene induces similar gene expression changes in testis of DNA repair proficient and deficient mice.

Verhofstad N, Pennings JL, van Oostrom CT, van Benthem J, van Schooten FJ, van Steeg H, Godschalk RW.

BMC Genomics. 2010 May 26;11:333. doi: 10.1186/1471-2164-11-333.

PMID:
20504355
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Comparison of clastogen-induced gene expression profiles in wild-type and DNA repair-deficient Rad54/Rad54B cells.

Mahabir AG, Schaap MM, Pennings JL, van Benthem J, Hendriksen CF, van Steeg H.

BMC Genomics. 2010 Jan 12;11:24. doi: 10.1186/1471-2164-11-24.

PMID:
20067618
[PubMed - indexed for MEDLINE]
Free PMC Article

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