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Year Number of Results
1948 2
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1958 3
1959 3
1960 4
1961 1
1962 2
1963 2
1964 6
1965 7
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1968 2
1969 1
1970 2
1971 6
1972 9
1973 13
1974 7
1975 28
1976 33
1977 52
1978 33
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1980 70
1981 54
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1983 75
1984 64
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1986 59
1987 61
1988 56
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1990 39
1991 66
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1993 56
1994 62
1995 57
1996 86
1997 60
1998 48
1999 74
2000 54
2001 86
2002 68
2003 76
2004 93
2005 103
2006 91
2007 106
2008 106
2009 113
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2011 137
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2013 163
2014 153
2015 155
2016 165
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2018 150
2019 156
2020 165
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2024 57

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4,161 results

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Umbelliferone delays the progression of diabetic nephropathy by inhibiting ferroptosis through activation of the Nrf-2/HO-1 pathway.
Jin T, Chen C. Jin T, et al. Food Chem Toxicol. 2022 May;163:112892. doi: 10.1016/j.fct.2022.112892. Epub 2022 Mar 10. Food Chem Toxicol. 2022. PMID: 35278496
Nrf2 plays an important role in regulating lipid peroxidation and is closely related to ferroptosis. Umbelliferone has antioxidant, anti-glycation and protective effects on diabetic mice. ...We demonstrated that knockdown of Nrf2 blocked the inhibitory effect of Umbelli …
Nrf2 plays an important role in regulating lipid peroxidation and is closely related to ferroptosis. Umbelliferone has antioxidant, a …
Uptake and modification of umbelliferone by various seedlings.
Hijazin T, Radwan A, Abouzeid S, Dräger G, Selmar D. Hijazin T, et al. Phytochemistry. 2019 Jan;157:194-199. doi: 10.1016/j.phytochem.2018.10.032. Epub 2018 Nov 12. Phytochemistry. 2019. PMID: 30439620
In all cases, a tremendous uptake of umbelliferone was observed. In plants that genuinely contain coumarins, the umbelliferone taken up was modified: in garden cress, it was hydroxylated and glucosylated to yield esculin, while in barley seedlings, the imported u …
In all cases, a tremendous uptake of umbelliferone was observed. In plants that genuinely contain coumarins, the umbelliferone …
Umbelliferone protects against methylglyoxal-induced HUVECs dysfunction through suppression of apoptosis and oxidative stress.
Zhang S, Zhang S, Li YY, Zhang Y, Wang H, Chen Y, Sun M. Zhang S, et al. J Appl Toxicol. 2023 Apr;43(4):490-499. doi: 10.1002/jat.4399. Epub 2022 Oct 12. J Appl Toxicol. 2023. PMID: 36170298
This study aimed to determine the effectiveness of umbelliferone in MGO-induced apoptosis and oxidative stress in endothelial cells. ...Moreover, we found that umbelliferone can activate Nrf2/HO-1 signaling. Importantly, silencing of Nrf2 signaling clearly eliminate …
This study aimed to determine the effectiveness of umbelliferone in MGO-induced apoptosis and oxidative stress in endothelial cells. …
Umbelliferone (7-hydroxycoumarin): A non-toxic antidiarrheal and antiulcerogenic coumarin.
Cruz LF, Figueiredo GF, Pedro LP, Amorin YM, Andrade JT, Passos TF, Rodrigues FF, Souza ILA, Gonçalves TPR, Dos Santos Lima LAR, Ferreira JMS, Araújo MGF. Cruz LF, et al. Biomed Pharmacother. 2020 Sep;129:110432. doi: 10.1016/j.biopha.2020.110432. Epub 2020 Jul 3. Biomed Pharmacother. 2020. PMID: 32768935 Free article.
Coumarins are an extensive class of phenolic compounds that can be found in plants, fungi and bacteria. The 7-hydroxycoumarin, also known as umbelliferone (UMB), is a compound that comes from coumarin and has been showing biological activities in other studie …
Coumarins are an extensive class of phenolic compounds that can be found in plants, fungi and bacteria. The 7-hydroxycoumarin, …
Umbelliferone protects against cerebral ischemic injury through selective autophagy of mitochondria.
Zhou Z, Zhang Y, Han F, Chen Z, Zheng Y. Zhou Z, et al. Neurochem Int. 2023 May;165:105520. doi: 10.1016/j.neuint.2023.105520. Epub 2023 Mar 17. Neurochem Int. 2023. PMID: 36933866
However, few compounds are available to selectively activate mitophagy without affecting autophagy flux. Here, we found that acute administration of Umbelliferone (UMB) upon reperfusion exerted neuroprotective effects against ischemic injury in mice subjected to transient …
However, few compounds are available to selectively activate mitophagy without affecting autophagy flux. Here, we found that acute administr …
Umbelliferone Ameliorates Complete Freund Adjuvant-Induced Arthritis via Reduction of NF-kappaB Signaling Pathway in Osteoclast Differentiation.
Wu G, Nie W, Wang Q, Hao Y, Gong S, Zheng Y, Lv H. Wu G, et al. Inflammation. 2021 Aug;44(4):1315-1329. doi: 10.1007/s10753-021-01418-x. Epub 2021 Jan 23. Inflammation. 2021. PMID: 33484396
In the current study, we scrutinize the effect of umbelliferone on CFA-induced arthritis model and explore the possible mechanism on bone destruction. ...Collectively, our results indicated the novel role of umbelliferone in osteoclastogenesis and proved that umb …
In the current study, we scrutinize the effect of umbelliferone on CFA-induced arthritis model and explore the possible mechanism on …
Umbelliferone derivatives exert neuroprotective effects by inhibiting monoamine oxidase A, self-amyloidbeta aggregation, and lipid peroxidation.
Seong SH, Ali MY, Jung HA, Choi JS. Seong SH, et al. Bioorg Chem. 2019 Nov;92:103293. doi: 10.1016/j.bioorg.2019.103293. Epub 2019 Sep 18. Bioorg Chem. 2019. PMID: 31557622
However, the effect of incorporating a formyl moiety in the umbelliferone scaffold has not been investigated. In this paper, we investigated the inhibitory activity of six coumarins, namely umbelliferone (1), 6-formyl umbelliferone (2), 8-formyl umbellifer …
However, the effect of incorporating a formyl moiety in the umbelliferone scaffold has not been investigated. In this paper, we inves …
Umbelliferone attenuates glycerol-induced myoglobinuric acute kidney injury through peroxisome proliferator-activated receptor-gamma agonism in rats.
Kaur T, Singh D, Pathak D, Singh AP, Singh B. Kaur T, et al. J Biochem Mol Toxicol. 2021 Nov;35(11):e22892. doi: 10.1002/jbt.22892. Epub 2021 Aug 19. J Biochem Mol Toxicol. 2021. PMID: 34409680
Serum creatine kinase was quantified to assess glycerol-induced muscle damage. Umbelliferone attenuated glycerol-induced change in biochemical parameters, oxidative stress, histological alterations, and renal apoptosis. Pretreatment with bisphenol A diglycidyl ether, a per …
Serum creatine kinase was quantified to assess glycerol-induced muscle damage. Umbelliferone attenuated glycerol-induced change in bi …
Umbelliferone attenuates gentamicin-induced renal toxicity by suppression of TLR-4/NF-kappaB-p65/NLRP-3 and JAK1/STAT-3 signaling pathways.
Hassanein EHM, Ali FEM, Kozman MR, Abd El-Ghafar OAM. Hassanein EHM, et al. Environ Sci Pollut Res Int. 2021 Mar;28(9):11558-11571. doi: 10.1007/s11356-020-11416-5. Epub 2020 Oct 30. Environ Sci Pollut Res Int. 2021. PMID: 33128149
This study aimed to investigate the possible nephroprotective effect of umbelliferone (UMB), against GNT-induced nephrotoxicity. Rats were allocated into the control group; UMB group (50 mg/kg/day, P.O. for 15 days); GNT group (100 mg/kg/day, i.p., for 8 days); and GNT + U …
This study aimed to investigate the possible nephroprotective effect of umbelliferone (UMB), against GNT-induced nephrotoxicity. Rats …
Umbelliferone attenuates cisplatin-induced acute kidney injury by inhibiting oxidative stress and inflammation via NRF2.
Yang Z, Ning R, Liu Q, Zang R, Liu S, Sun S. Yang Z, et al. Physiol Rep. 2023 Dec;11(23):e15879. doi: 10.14814/phy2.15879. Physiol Rep. 2023. PMID: 38030388 Free PMC article.
In this study, we investigated the nephroprotective effects of Umbelliferone (UMB) against cisplatin-induced acute kidney injury (AKI). ...
In this study, we investigated the nephroprotective effects of Umbelliferone (UMB) against cisplatin-induced acute kidney injury (AKI …
4,161 results

Searches related to "umbelliferone"