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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 2
1949 2
1956 1
1959 1
1962 1
1965 2
1966 1
1969 2
1970 3
1971 2
1974 1
1975 2
1976 3
1977 1
1978 3
1979 4
1980 5
1981 2
1982 11
1983 3
1984 8
1985 5
1986 6
1987 6
1988 2
1989 4
1990 10
1991 9
1992 4
1993 8
1994 10
1995 15
1996 10
1997 9
1998 12
1999 4
2000 7
2001 5
2002 12
2003 16
2004 7
2005 13
2006 13
2007 15
2008 6
2009 16
2010 13
2011 14
2012 10
2013 10
2014 16
2015 13
2016 10
2017 14
2018 13
2019 15
2020 9
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2022 11
2023 19
2024 7

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442 results

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Page 1
Formation mechanisms of trichloromethyl-containing compounds in the terrestrial environment: a critical review.
Breider F, Albers CN. Breider F, et al. Chemosphere. 2015 Jan;119:145-154. doi: 10.1016/j.chemosphere.2014.05.080. Epub 2014 Jun 27. Chemosphere. 2015. PMID: 24974224 Review.
Natural trichloromethyl compounds present in the terrestrial environment are important contributors to chlorine in the lower atmosphere and may be also a cause for concern when high concentrations are detected in soils and groundwater. ...This critical review summarizes ou …
Natural trichloromethyl compounds present in the terrestrial environment are important contributors to chlorine in the lower atmosphe …
Regiocontrolled Synthesis of 1-Substituted-3(5)-carboxyalkyl-1H-pyrazoles Using Trichloromethyl Enones.
Pereira GS, Mittersteiner M, Bonacorso HG, Martins MAP, Zanatta N. Pereira GS, et al. ACS Omega. 2023 May 4;8(19):17274-17287. doi: 10.1021/acsomega.3c01879. eCollection 2023 May 16. ACS Omega. 2023. PMID: 37214703 Free PMC article.
In this work, we present a regiocontrolled methodology to prepare 1-substituted-3(5)-carboxyalkyl-1H-pyrazoles using trichloromethyl enones as starting materials. It was found that the selectivity of the reaction depends on the nature of the hydrazine: when using arylhydra …
In this work, we present a regiocontrolled methodology to prepare 1-substituted-3(5)-carboxyalkyl-1H-pyrazoles using trichloromethyl …
Biochemical and pharmacological characterization of 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline: a biologically relevant neurotoxin?
Riederer P, Foley P, Bringmann G, Feineis D, Brückner R, Gerlach M. Riederer P, et al. Eur J Pharmacol. 2002 May 3;442(1-2):1-16. doi: 10.1016/s0014-2999(02)01308-0. Eur J Pharmacol. 2002. PMID: 12020676 Review.
The recognition in 1970s that 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a neurotoxic by-product of illicit meperidine synthesis, elicits parkinsonian symptoms in primates, including man, prompted the search for naturally occurring analogs which might be involved in hum …
The recognition in 1970s that 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a neurotoxic by-product of illicit meperidine synthesis, …
Antiplasmodial 2-thiophenoxy-3-trichloromethyl quinoxalines target the apicoplast of Plasmodium falciparum.
Amrane D, Primas N, Arnold CS, Hutter S, Louis B, Sanz-Serrano J, Azqueta A, Amanzougaghene N, Tajeri S, Mazier D, Verhaeghe P, Azas N, Botté C, Vanelle P. Amrane D, et al. Eur J Med Chem. 2021 Nov 15;224:113722. doi: 10.1016/j.ejmech.2021.113722. Epub 2021 Jul 29. Eur J Med Chem. 2021. PMID: 34364164
Moreover, hit-compound 3k was not cytotoxic on VERO or CHO cell lines and was not genotoxic in the in vitro comet assay. Activity cliffs were observed when the trichloromethyl group was replaced by CH(3), CF(3) or H, showing that this group played a key role in the antipla …
Moreover, hit-compound 3k was not cytotoxic on VERO or CHO cell lines and was not genotoxic in the in vitro comet assay. Activity cliffs wer …
Photodissociation of the trichloromethyl radical: photofragment imaging and femtosecond photoelectron spectroscopy.
Matthaei CT, Mukhopadhyay DP, Röder A, Poisson L, Fischer I. Matthaei CT, et al. Phys Chem Chem Phys. 2022 Jan 4;24(2):928-940. doi: 10.1039/d1cp04084g. Phys Chem Chem Phys. 2022. PMID: 34913455
Here we investigate the photodissociation dynamics of the trichloromethyl radical, CCl(3) after excitation in the ultraviolet. While the primary processes directly after light absorption are followed by femtosecond-time resolved photoionisation and photoelectron spectrosco …
Here we investigate the photodissociation dynamics of the trichloromethyl radical, CCl(3) after excitation in the ultraviolet. While …
1-Trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) Alters Cell Cycle Progression in Human Neuroblastoma Cell Lines.
Sharma RK, Candelario-Jalil E, Feineis D, Bringmann G, Fiebich BL, Akundi RS. Sharma RK, et al. Neurotox Res. 2017 Nov;32(4):649-660. doi: 10.1007/s12640-017-9782-1. Epub 2017 Jul 18. Neurotox Res. 2017. PMID: 28721631
1-Trichloromethyl-1,2,3,4-tetrahydro-beta-carboline, abbreviated as TaClo, is an endogenous neurotoxin capable of formation in the brain through the condensation of neuronal tryptamine with ingested exogenous toxins such as trichloroethylene or chloral hydrate. ...
1-Trichloromethyl-1,2,3,4-tetrahydro-beta-carboline, abbreviated as TaClo, is an endogenous neurotoxin capable of formation in the br …
The TaClo concept: 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo), a new toxin for dopaminergic neurons.
Bringmann G, God R, Feineis D, Wesemann W, Riederer P, Rausch WD, Reichmann H, Sontag KH. Bringmann G, et al. J Neural Transm Suppl. 1995;46:235-44. J Neural Transm Suppl. 1995. PMID: 8821060 Review.
Due to its structural analogy to the neurotoxin MPTP, "TaClo" (1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline), a compound readily originating in vitro from tryptamine ("Ta") and chloral ("Clo"), is discussed as a potential natural inducer of parkinsonian-like symptom …
Due to its structural analogy to the neurotoxin MPTP, "TaClo" (1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline), a compound readi …
Ultrasound-promoted synthesis of 3-trichloromethyl-5-alkyl(aryl)-1,2,4-oxadiazoles.
Bretanha LC, Teixeira VE, Ritter M, Siqueira GM, Cunico W, Pereira CM, Freitag RA. Bretanha LC, et al. Ultrason Sonochem. 2011 May;18(3):704-7. doi: 10.1016/j.ultsonch.2010.09.016. Epub 2010 Oct 14. Ultrason Sonochem. 2011. PMID: 21115383 Free article.
The alternative synthesis of 12 1,2,4-oxadiazoles using ultrasound irradiation from trichloroacetoamidoxime and acyl chlorides is reported. Seven of them are novel compounds. The 3-trichloromethyl-5alkyl(aryl)-1,2,4-oxadiazoles have been synthesised in better yields and sh …
The alternative synthesis of 12 1,2,4-oxadiazoles using ultrasound irradiation from trichloroacetoamidoxime and acyl chlorides is reported. …
1-Trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) Induces the Apoptosis of Dopaminergic Neurons via Oxidative Stress and Neuroinflammation.
Yang Y, Pang B, Liu Z, Li J, Zhang Z, Zhang R, Hou X, Guo H, Chi L, Pang Q, Xin T. Yang Y, et al. Oxid Med Cell Longev. 2019 Mar 7;2019:1292891. doi: 10.1155/2019/1292891. eCollection 2019. Oxid Med Cell Longev. 2019. PMID: 30984332 Free PMC article.
Several in vitro studies have revealed the neurotoxicity of 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo). However, the underlying mechanism has not been completely elucidated, particularly in vivo. ...
Several in vitro studies have revealed the neurotoxicity of 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo). However, the …
442 results