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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1951 2
1953 2
1955 6
1956 6
1957 1
1958 4
1959 7
1960 3
1961 10
1962 17
1963 12
1964 14
1965 6
1966 1
1967 7
1968 5
1969 3
1970 31
1971 205
1972 240
1973 305
1974 300
1975 263
1976 285
1977 270
1978 296
1979 301
1980 301
1981 319
1982 303
1983 348
1984 365
1985 420
1986 400
1987 385
1988 466
1989 422
1990 395
1991 468
1992 518
1993 541
1994 574
1995 639
1996 617
1997 642
1998 735
1999 746
2000 805
2001 924
2002 1039
2003 1195
2004 1253
2005 1406
2006 1612
2007 1781
2008 1877
2009 1979
2010 2174
2011 2405
2012 2692
2013 2836
2014 2836
2015 2888
2016 2930
2017 2948
2018 2927
2019 3037
2020 3166
2021 3179
2022 2823
2023 2489
2024 840

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60,232 results

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Page 1
5-methylcytosine RNA methyltransferases and their potential roles in cancer.
Li M, Tao Z, Zhao Y, Li L, Zheng J, Li Z, Chen X. Li M, et al. J Transl Med. 2022 May 13;20(1):214. doi: 10.1186/s12967-022-03427-2. J Transl Med. 2022. PMID: 35562754 Free PMC article. Review.
These RNA modifiers regulate the expression of multiple oncogenes such as fizzy-related-1, forkhead box protein C2, Grb associated-binding protein 2, and TEA domain transcription factor 1, facilitating the pathogenesis and progression of cancers. Furthermore, the aberrant express …
These RNA modifiers regulate the expression of multiple oncogenes such as fizzy-related-1, forkhead box protein C2, Grb associated-binding p …
Eukaryotic 5-methylcytosine (m5C) RNA Methyltransferases: Mechanisms, Cellular Functions, and Links to Disease.
Bohnsack KE, Höbartner C, Bohnsack MT. Bohnsack KE, et al. Genes (Basel). 2019 Jan 30;10(2):102. doi: 10.3390/genes10020102. Genes (Basel). 2019. PMID: 30704115 Free PMC article. Review.
In recent years, substrate RNAs and modification target nucleotides for each of these methyltransferases have been identified, and structural and biochemical analyses have provided the first insights into how each of these enzymes achieves target specificity. ...Importantl …
In recent years, substrate RNAs and modification target nucleotides for each of these methyltransferases have been identified, and st …
RNA (C5-cytosine) Methyltransferases.
Kuznetsova SA, Petrukov KS, Pletnev FI, Sergiev PV, Dontsova OA. Kuznetsova SA, et al. Biochemistry (Mosc). 2019 Aug;84(8):851-869. doi: 10.1134/S0006297919080029. Biochemistry (Mosc). 2019. PMID: 31522668 Review.
The functions of RNA (C5-cytosine) methyltransferases unassociated with their methylation activity are discussed. Special attention is given to the similarities and differences in the structures and mechanisms of action of RNA and DNA methyltransferases. The data on …
The functions of RNA (C5-cytosine) methyltransferases unassociated with their methylation activity are discussed. Special attention i …
Alkylating enzymes.
Wessjohann LA, Keim J, Weigel B, Dippe M. Wessjohann LA, et al. Curr Opin Chem Biol. 2013 Apr;17(2):229-35. doi: 10.1016/j.cbpa.2013.02.016. Epub 2013 Mar 18. Curr Opin Chem Biol. 2013. PMID: 23518239 Review.
Two categories of alkylating enzymes become increasingly relevant for applications: firstly prenyltransferases and terpene synthases (including terpene cyclases), which are used in the production of terpenoids such as artemisinin, or meroterpenoids like alkylated phenolics and in …
Two categories of alkylating enzymes become increasingly relevant for applications: firstly prenyltransferases and terpene synthases (includ …
Biallelic variants in NSUN6 cause an autosomal recessive neurodevelopmental disorder.
Mattioli F, Worpenberg L, Li CT, Ibrahim N, Naz S, Sharif S, Firouzabadi SG, Vosoogh S, Saraeva-Lamri R, Raymond L, Trujillo C, Guex N, Antonarakis SE, Ansar M, Darvish H, Liu RJ, Roignant JY, Reymond A. Mattioli F, et al. Genet Med. 2023 Sep;25(9):100900. doi: 10.1016/j.gim.2023.100900. Epub 2023 May 21. Genet Med. 2023. PMID: 37226891 Free article.
PURPOSE: 5-methylcytosine RNA modifications are driven by NSUN methyltransferases. Although variants in NSUN2 and NSUN3 were associated with neurodevelopmental diseases, the physiological role of NSUN6 modifications on transfer RNAs and messenger RNAs remained elusive. ...
PURPOSE: 5-methylcytosine RNA modifications are driven by NSUN methyltransferases. Although variants in NSUN2 and NSUN3 were associat …
Structure, activity and function of the lysine methyltransferase SETD5.
Li M, Hou Y, Zhang Z, Zhang B, Huang T, Sun A, Shao G, Lin Q. Li M, et al. Front Endocrinol (Lausanne). 2023 Feb 17;14:1089527. doi: 10.3389/fendo.2023.1089527. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 36875494 Free PMC article. Review.
Detection, regulation, and functions of RNA N6-methyladenosine modification in plants.
Tang J, Chen S, Jia G. Tang J, et al. Plant Commun. 2023 May 8;4(3):100546. doi: 10.1016/j.xplc.2023.100546. Epub 2023 Jan 10. Plant Commun. 2023. PMID: 36627844 Free PMC article. Review.
N(6)-Methyladenosine (m(6)A) is the most abundant internal chemical modification in eukaryotic mRNA and plays important roles in gene expression regulation, including transcriptional and post-transcriptional regulation. m(6)A is a reversible modification that is installed, remove …
N(6)-Methyladenosine (m(6)A) is the most abundant internal chemical modification in eukaryotic mRNA and plays important roles in gene expres …
Adenosylmethioninehomocysteine transmethylase.
SHAPIRO SK. SHAPIRO SK. Biochim Biophys Acta. 1958 Aug;29(2):405-9. doi: 10.1016/0006-3002(58)90199-9. Biochim Biophys Acta. 1958. PMID: 13572358 No abstract available.
Recent advances in methyltransferase biocatalysis.
Bennett MR, Shepherd SA, Cronin VA, Micklefield J. Bennett MR, et al. Curr Opin Chem Biol. 2017 Apr;37:97-106. doi: 10.1016/j.cbpa.2017.01.020. Epub 2017 Mar 2. Curr Opin Chem Biol. 2017. PMID: 28259085 Review.
Enzymatic approaches that enable the more efficient generation of S-adenosyl methionine analogs, including more stable analogs, will also be described; this has expanded the biocatalytic repertoire of methyltransferases from methylation to a broader range of alkylation rea …
Enzymatic approaches that enable the more efficient generation of S-adenosyl methionine analogs, including more stable analogs, will also be …
Towards the structural characterization of the human methyltransferome.
Fenwick MK, Ealick SE. Fenwick MK, et al. Curr Opin Struct Biol. 2018 Dec;53:12-21. doi: 10.1016/j.sbi.2018.03.007. Epub 2018 Apr 11. Curr Opin Struct Biol. 2018. PMID: 29654888 Review.
Approximately 2000 structures of methyltransferases (MTases) are currently available, displaying fifteen different folds for binding a methyl donor and providing molecular level insight into nearly half the human methyltransferome. ...
Approximately 2000 structures of methyltransferases (MTases) are currently available, displaying fifteen different folds for binding …
60,232 results
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