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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1944 1
1947 1
1948 2
1949 2
1950 6
1951 7
1952 3
1953 3
1954 9
1955 10
1956 11
1957 2
1958 3
1959 10
1960 5
1961 9
1962 10
1963 12
1964 13
1965 11
1966 38
1967 52
1968 69
1969 104
1970 138
1971 175
1972 414
1973 594
1974 864
1975 925
1976 1020
1977 947
1978 1045
1979 1224
1980 1246
1981 1514
1982 1767
1983 2132
1984 2621
1985 3116
1986 3676
1987 4603
1988 5511
1989 6623
1990 7667
1991 8795
1992 10144
1993 11597
1994 13288
1995 15417
1996 17020
1997 18731
1998 20090
1999 21098
2000 23061
2001 24514
2002 25480
2003 27217
2004 29479
2005 31283
2006 33608
2007 35378
2008 37093
2009 38262
2010 41196
2011 45200
2012 49271
2013 52349
2014 53542
2015 55181
2016 54695
2017 56092
2018 57702
2019 60459
2020 65266
2021 69057
2022 63004
2023 57846
2024 21074

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1,174,367 results

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Page 1
Making sense of the natural antisense transcript puzzle.
Reis RS, Poirier Y. Reis RS, et al. Trends Plant Sci. 2021 Nov;26(11):1104-1115. doi: 10.1016/j.tplants.2021.07.004. Epub 2021 Jul 21. Trends Plant Sci. 2021. PMID: 34303604 Review.
In this opinion, we show that evidence does not support gene silencing as a major role for antisense transcription. In fact, it is more likely that antisense transcripts play diverse functions in gene regulation. ...By moving beyond the gene silencing paradigm, we a …
In this opinion, we show that evidence does not support gene silencing as a major role for antisense transcription. In fact, it is mo …
Strategies to Inhibit Hepatitis B Virus at the Transcript Level.
Qu B, Brown RJP. Qu B, et al. Viruses. 2021 Jul 9;13(7):1327. doi: 10.3390/v13071327. Viruses. 2021. PMID: 34372533 Free PMC article. Review.
This review details the latest developments in antivirals that inhibit HBV gene transcription or destabilize viral transcripts. Notably, nuclear receptor agonists exhibit potent inhibition of viral gene transcription from cccDNA. Small molecule inhibitors rep …
This review details the latest developments in antivirals that inhibit HBV gene transcription or destabilize viral transcripts …
From transcript to protein.
Dreyfuss G, Hentze M, Lamond AI. Dreyfuss G, et al. Cell. 1996 Jun 28;85(7):963-72. doi: 10.1016/s0092-8674(00)81298-2. Cell. 1996. PMID: 8674124 Free article. Review. No abstract available.
It's a DoG-eat-DoG world-altered transcriptional mechanisms drive downstream-of-gene (DoG) transcript production.
Morgan M, Shiekhattar R, Shilatifard A, Lauberth SM. Morgan M, et al. Mol Cell. 2022 Jun 2;82(11):1981-1991. doi: 10.1016/j.molcel.2022.04.008. Epub 2022 Apr 28. Mol Cell. 2022. PMID: 35487209 Free PMC article. Review.
Among the most recently identified ncRNAs are downstream-of-gene (DoG)-containing transcripts that are produced by widespread transcriptional readthrough. The discovery of DoGs has set the stage for future studies to address many unanswered questions regarding the m …
Among the most recently identified ncRNAs are downstream-of-gene (DoG)-containing transcripts that are produced by widespread tran …
Universally high transcript error rates in bacteria.
Li W, Lynch M. Li W, et al. Elife. 2020 May 29;9:e54898. doi: 10.7554/eLife.54898. Elife. 2020. PMID: 32469307 Free PMC article.
Errors can occur at any level during the replication and transcription of genetic information. Genetic mutations derived mainly from replication errors have been extensively studied. ...Similar to genetic mutations, errors that arise when forming RNA …
Errors can occur at any level during the replication and transcription of genetic information. Genetic mutations derive …
RNA polymerase II transcript elongation.
Svejstrup JQ. Svejstrup JQ. Biochim Biophys Acta. 2013 Jan;1829(1):1. doi: 10.1016/j.bbagrm.2012.12.008. Biochim Biophys Acta. 2013. PMID: 23312801 No abstract available.
Regulatory roles of Alu transcript on gene expression.
Zhang L, Chen JG, Zhao Q. Zhang L, et al. Exp Cell Res. 2015 Oct 15;338(1):113-8. doi: 10.1016/j.yexcr.2015.07.019. Epub 2015 Jul 22. Exp Cell Res. 2015. PMID: 26210645 Review.
The main functions of Alu transcript focus on gene regulation both at transcriptional and post-transcriptional levels. This review summarizes major functions of Alu transcripts on gene expression and highlights molecular mechanisms dependent on conserv …
The main functions of Alu transcript focus on gene regulation both at transcriptional and post-transcriptional levels. …
Knowing when to stop: Transcription termination on protein-coding genes by eukaryotic RNAPII.
Rodríguez-Molina JB, West S, Passmore LA. Rodríguez-Molina JB, et al. Mol Cell. 2023 Feb 2;83(3):404-415. doi: 10.1016/j.molcel.2022.12.021. Epub 2023 Jan 11. Mol Cell. 2023. PMID: 36634677 Free PMC article. Review.
Transcription termination on protein-coding genes is intimately linked with 3' end cleavage and polyadenylation of transcripts, and it generally results in the production of a mature mRNA that is exported from the nucleus. Termination on many non-coding genes can al …
Transcription termination on protein-coding genes is intimately linked with 3' end cleavage and polyadenylation of transcripts …
Transcript elongation on a nucleoprotein template.
Hartzog GA, Speer JL, Lindstrom DL. Hartzog GA, et al. Biochim Biophys Acta. 2002 Sep 13;1577(2):276-86. doi: 10.1016/s0167-4781(02)00458-x. Biochim Biophys Acta. 2002. PMID: 12213658 Review.
Chromatin forms a general, repeating barrier to elongation of transcripts by eukaryotic RNA polymerases. Recent studies of nucleosome structure and histone modifications reveal a set of likely mechanisms for control of elongation through chromatin. Genetic and bioch …
Chromatin forms a general, repeating barrier to elongation of transcripts by eukaryotic RNA polymerases. Recent studies of nucleosome …
Alternative mRNA transcription, processing, and translation: insights from RNA sequencing.
de Klerk E, 't Hoen PA. de Klerk E, et al. Trends Genet. 2015 Mar;31(3):128-39. doi: 10.1016/j.tig.2015.01.001. Epub 2015 Jan 30. Trends Genet. 2015. PMID: 25648499 Review.
The human transcriptome comprises >80,000 protein-coding transcripts and the estimated number of proteins synthesized from these transcripts is in the range of 250,000 to 1 million. These transcripts and proteins are encoded by less than 20,000 genes, sugg …
The human transcriptome comprises >80,000 protein-coding transcripts and the estimated number of proteins synthesized from these …
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