Effect of lithium carbonate on circadian periodicity in humans

Pharmakopsychiatr Neuropsychopharmakol. 1979 Nov;12(6):423-5. doi: 10.1055/s-0028-1094638.

Abstract

Five groups of two volunteers lived during four weeks under arctic summer conditions (Spitsbergen) isolated in huts, without time information. They received lithium carbonate or placebo. All showed free-run of their circadian temperature and activity/rest rhythms with periods longer than 24 hours. Under lithium carbonate, a period-lengthening effect can be shown. This could help to understand theprophylactic effect of lithium salts in manic-depressive episodes.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Body Temperature / drug effects
  • Circadian Rhythm / drug effects*
  • Humans
  • Lithium / pharmacology*

Substances

  • Lithium