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Year Number of Results
1781 1
1783 1
1786 1
1787 2
1788 3
1790 3
1796 3
1797 6
1798 1
1799 5
1800 5
1801 4
1803 1
1804 2
1805 1
1806 1
1807 3
1808 1
1809 1
1811 1
1812 4
1813 2
1814 4
1815 1
1816 3
1817 3
1818 4
1820 4
1821 2
1822 1
1823 2
1824 4
1826 6
1827 3
1828 5
1829 2
1830 1
1831 3
1832 1
1833 1
1834 5
1835 7
1839 2
1840 3
1841 3
1842 7
1843 9
1844 4
1845 2
1846 7
1847 1
1848 5
1849 4
1850 5
1851 1
1852 5
1853 4
1854 1
1855 1
1856 2
1858 2
1859 1
1860 1
1862 2
1865 1
1866 2
1867 6
1868 2
1869 3
1870 1
1871 2
1872 4
1873 1
1874 1
1875 2
1877 2
1878 3
1880 1
1881 2
1882 2
1883 4
1884 3
1885 2
1886 2
1887 1
1888 1
1889 1
1890 1
1891 2
1894 1
1895 4
1896 1
1897 3
1898 3
1899 2
1900 5
1901 1
1902 2
1903 1
1904 1
1905 1
1906 3
1908 2
1909 5
1910 3
1911 3
1912 5
1913 6
1914 4
1915 6
1916 6
1917 4
1918 4
1919 1
1920 10
1921 2
1922 2
1923 7
1924 5
1925 6
1926 5
1927 3
1928 8
1929 4
1930 5
1931 7
1932 6
1933 5
1934 10
1935 6
1936 6
1937 8
1938 12
1939 9
1940 3
1941 6
1942 5
1943 7
1944 4
1945 18
1946 43
1947 66
1948 56
1949 67
1950 77
1951 94
1952 105
1953 126
1954 142
1955 163
1956 112
1957 138
1958 148
1959 151
1960 139
1961 168
1962 197
1963 218
1964 278
1965 346
1966 418
1967 462
1968 556
1969 642
1970 711
1971 811
1972 904
1973 1104
1974 1171
1975 3002
1976 3161
1977 3188
1978 3223
1979 3700
1980 4037
1981 4362
1982 4744
1983 5819
1984 6298
1985 6712
1986 7227
1987 7872
1988 8699
1989 9779
1990 10662
1991 11298
1992 12026
1993 12515
1994 13274
1995 14157
1996 14783
1997 15214
1998 15817
1999 16292
2000 17227
2001 17170
2002 17110
2003 17829
2004 18517
2005 19350
2006 20120
2007 19988
2008 20452
2009 20392
2010 21243
2011 21928
2012 22636
2013 22985
2014 23145
2015 22668
2016 22141
2017 21736
2018 21559
2019 21768
2020 22760
2021 23566
2022 22007
2023 20811
2024 8162

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682,089 results

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Page 1
Metformin Cessation and Dementia Incidence.
Zimmerman SC, Ferguson EL, Choudhary V, Ranatunga DK, Oni-Orisan A, Hayes-Larson E, Duarte Folle A, Mayeda ER, Whitmer RA, Gilsanz P, Power MC, Schaefer C, Glymour MM, Ackley SF. Zimmerman SC, et al. JAMA Netw Open. 2023 Oct 2;6(10):e2339723. doi: 10.1001/jamanetworkopen.2023.39723. JAMA Netw Open. 2023. PMID: 37878309 Free PMC article.
Data were analyzed from November 2021 through September 2023. EXPOSURES: A total of 12 220 early terminators, individuals who stopped metformin with normal estimated glomerular filtration rate (eGFR), were compared with routine metformin users, who had not yet terminate …
Data were analyzed from November 2021 through September 2023. EXPOSURES: A total of 12 220 early terminators, individuals who stopped …
Rho Protein: Roles and Mechanisms.
Mitra P, Ghosh G, Hafeezunnisa M, Sen R. Mitra P, et al. Annu Rev Microbiol. 2017 Sep 8;71:687-709. doi: 10.1146/annurev-micro-030117-020432. Epub 2017 Jul 21. Annu Rev Microbiol. 2017. PMID: 28731845 Review.
At the end of the multistep transcription process, the elongating RNA polymerase (RNAP) is dislodged from the DNA template either at specific DNA sequences, called the terminators, or by a nascent RNA-dependent helicase, Rho. In Escherichia coli, about half of the transcri …
At the end of the multistep transcription process, the elongating RNA polymerase (RNAP) is dislodged from the DNA template either at specifi …
Features and factors that dictate if terminating ribosomes cause or counteract nonsense-mediated mRNA decay.
Embree CM, Abu-Alhasan R, Singh G. Embree CM, et al. J Biol Chem. 2022 Nov;298(11):102592. doi: 10.1016/j.jbc.2022.102592. Epub 2022 Oct 13. J Biol Chem. 2022. PMID: 36244451 Free PMC article. Review.
Such transcript surveillance by NMD is intimately linked to translation termination. When a ribosome terminates translation at a normal termination codon, NMD is not activated, and mRNA can undergo repeated rounds of translation. On the other hand, when trans …
Such transcript surveillance by NMD is intimately linked to translation termination. When a ribosome terminates translation at …
Deciphering the molecular mechanism of stop codon readthrough.
Palma M, Lejeune F. Palma M, et al. Biol Rev Camb Philos Soc. 2021 Feb;96(1):310-329. doi: 10.1111/brv.12657. Epub 2020 Oct 22. Biol Rev Camb Philos Soc. 2021. PMID: 33089614 Free article. Review.
Recognition of the stop codon by the translation machinery is essential to terminating translation at the right position and to synthesizing a protein of the correct size. Under certain conditions, the stop codon can be recognized as a coding codon promoting translation, w …
Recognition of the stop codon by the translation machinery is essential to terminating translation at the right position and to synth …
Plant terminators: the unsung heroes of gene expression.
de Felippes FF, Waterhouse PM. de Felippes FF, et al. J Exp Bot. 2023 Apr 9;74(7):2239-2250. doi: 10.1093/jxb/erac467. J Exp Bot. 2023. PMID: 36477559 Free PMC article. Review.
To be properly expressed, genes need to be accompanied by a terminator, a region downstream of the coding sequence that contains the information necessary for the maturation of the mRNA 3' end. ...We give special attention to an aspect often overlooked, the effect that dif …
To be properly expressed, genes need to be accompanied by a terminator, a region downstream of the coding sequence that contains the …
Bidirectional terminators: an underestimated aspect of gene regulation.
Robert F. Robert F. Curr Genet. 2018 Apr;64(2):389-391. doi: 10.1007/s00294-017-0763-y. Epub 2017 Oct 10. Curr Genet. 2018. PMID: 29018946 Review.
Recent experimental and computational work revealed that transcriptional terminators in Saccharomyces cerevisiae can terminate transcription coming from both directions. ...
Recent experimental and computational work revealed that transcriptional terminators in Saccharomyces cerevisiae can terminate …
Factor-stimulated intrinsic termination: getting by with a little help from some friends.
Mandell ZF, Zemba D, Babitzke P. Mandell ZF, et al. Transcription. 2022 Aug-Oct;13(4-5):96-108. doi: 10.1080/21541264.2022.2127602. Epub 2022 Sep 25. Transcription. 2022. PMID: 36154805 Free PMC article. Review.
In NusA-stimulated intrinsic termination, NusA facilitates the formation of weak terminator hairpins and compensates for distal U-rich tract interruptions. ...In Rho-stimulated intrinsic termination, Rho prevents the formation of antiterminator-like RNA struc …
In NusA-stimulated intrinsic termination, NusA facilitates the formation of weak terminator hairpins and compensates for dista …
Design of a Temperature-Responsive Transcription Terminator.
Roßmanith J, Weskamp M, Narberhaus F. Roßmanith J, et al. ACS Synth Biol. 2018 Feb 16;7(2):613-621. doi: 10.1021/acssynbio.7b00356. Epub 2017 Dec 12. ACS Synth Biol. 2018. PMID: 29191010
In this study, we exploited temperature-responsive RNAT structures to design regulatory elements that control transcription termination instead of translation initiation in Escherichia coli. In order to mimic the structure of factor-independent intrinsic terminators …
In this study, we exploited temperature-responsive RNAT structures to design regulatory elements that control transcription termination …
Comprehensive transcription terminator atlas for Bacillus subtilis.
Mandell ZF, Vishwakarma RK, Yakhnin H, Murakami KS, Kashlev M, Babitzke P. Mandell ZF, et al. Nat Microbiol. 2022 Nov;7(11):1918-1931. doi: 10.1038/s41564-022-01240-7. Epub 2022 Oct 3. Nat Microbiol. 2022. PMID: 36192538 Free PMC article.
We also show that Rho stimulates termination at 10% of the intrinsic terminators in vivo. We recapitulated Rho-stimulated intrinsic termination at 5 terminators in vitro and found that Rho requires the KOW domain of NusG to stimulate this process at on …
We also show that Rho stimulates termination at 10% of the intrinsic terminators in vivo. We recapitulated Rho-stimulated intr …
Interplay between chromosomal architecture and termination of DNA replication in bacteria.
Goodall DJ, Warecka D, Hawkins M, Rudolph CJ. Goodall DJ, et al. Front Microbiol. 2023 Jun 26;14:1180848. doi: 10.3389/fmicb.2023.1180848. eCollection 2023. Front Microbiol. 2023. PMID: 37434703 Free PMC article. Review.
Bacterial models with a circular chromosome and a single bidirectional origin offer the distinct advantage that there is normally just one fusion event between two replication fork complexes as synthesis terminates. Moreover, whereas termination of replication appea …
Bacterial models with a circular chromosome and a single bidirectional origin offer the distinct advantage that there is normally just one f …
682,089 results
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