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Results: 1 to 20 of 305

1.

Genetic depletion and pharmacological targeting of αv integrin in breast cancer cells impairs metastasis in zebrafish and mouse xenograft models.

Li Y, Drabsch Y, Pujuguet P, Ren J, van Laar T, Zhang L, van Dam H, Clément-Lacroix P, Ten Dijke P.

Breast Cancer Res. 2015 Feb 25;17:28. doi: 10.1186/s13058-015-0537-8.

2.

Transforming Growth Factor β Signaling in Colorectal Cancer Cells with Microsatellite Instability Despite Biallelic Mutations in TGFBR2.

de Miranda NF, van Dinther M, van den Akker BE, van Wezel T, Ten Dijke P, Morreau H.

Gastroenterology. 2015 Feb 28. pii: S0016-5085(15)00301-7. doi: 10.1053/j.gastro.2015.02.052. [Epub ahead of print]

PMID:
25736321
3.

Disorganised stroma determined on pre-treatment breast cancer biopsies is associated with poor response to neoadjuvant chemotherapy: Results from the NEOZOTAC trial.

Dekker TJ, Charehbili A, Smit VT, Ten Dijke P, Meershoek-Klein Kranenbarg E, van de Velde CJ, Nortier JW, Tollenaar RA, Mesker WE, Kroep JR.

Mol Oncol. 2015 Feb 14. pii: S1574-7891(15)00024-1. doi: 10.1016/j.molonc.2015.02.001. [Epub ahead of print]

PMID:
25735561
4.

The high affinity ALK1-ligand BMP9 induces a hypertrophy-like state in chondrocytes that is antagonized by TGFβ1.

van Caam A, Blaney Davidson E, Garcia de Vinuesa A, van Geffen E, van den Berg W, Goumans MJ, Ten Dijke P, van der Kraan P.

Osteoarthritis Cartilage. 2015 Feb 12. pii: S1063-4584(15)00048-5. doi: 10.1016/j.joca.2015.02.007. [Epub ahead of print]

PMID:
25681563
5.

14-3-3ζ turns TGF-β to the dark side.

ten Dijke P, van Dam H.

Cancer Cell. 2015 Feb 9;27(2):151-3. doi: 10.1016/j.ccell.2015.01.005.

PMID:
25670073
6.

SLUG is expressed in endothelial cells lacking primary cilia to promote cellular calcification.

Sánchez-Duffhues G, de Vinuesa AG, Lindeman JH, Mulder-Stapel A, DeRuiter MC, Van Munsteren C, Goumans MJ, Hierck BP, Ten Dijke P.

Arterioscler Thromb Vasc Biol. 2015 Mar;35(3):616-27. doi: 10.1161/ATVBAHA.115.305268. Epub 2015 Jan 29.

PMID:
25633317
7.

Clinical Utility Gene Card for: Fibrodysplasia ossificans progressiva.

Bravenboer N, Micha D, Triffit JT, Bullock AN, Ravazollo R, Bocciardi R, di Rocco M, Netelenbos JC, Ten Dijke P, Sánchez-Duffhues G, Kaplan FS, Shore EM, Pignolo RJ, Seemann P, Ventura F, Beaujat G, Eekhoff EM, Pals G.

Eur J Hum Genet. 2015 Jan 21. doi: 10.1038/ejhg.2014.274. [Epub ahead of print] No abstract available.

PMID:
25604857
8.

Inhibition of TGFβ type I receptor activity facilitates liver regeneration upon acute CCl4 intoxication in mice.

Karkampouna S, Goumans MJ, Ten Dijke P, Dooley S, Kruithof-de Julio M.

Arch Toxicol. 2015 Jan 8. [Epub ahead of print]

PMID:
25566828
9.

Ter94/VCP is a novel component involved in BMP signaling.

Zeng Z, de Gorter DJ, Kowalski M, ten Dijke P, Shimmi O.

PLoS One. 2014 Dec 3;9(12):e114475. doi: 10.1371/journal.pone.0114475. eCollection 2014.

10.

The BMP pathway either enhances or inhibits the Wnt pathway depending on the SMAD4 and p53 status in CRC.

Voorneveld PW, Kodach LL, Jacobs RJ, van Noesel CJ, Peppelenbosch MP, Korkmaz KS, Molendijk I, Dekker E, Morreau H, van Pelt GW, Tollenaar RA, Mesker W, Hawinkels LJ, Paauwe M, Verspaget HW, Geraets DT, Hommes DW, Offerhaus GJ, van den Brink GR, Ten Dijke P, Hardwick JC.

Br J Cancer. 2015 Jan 6;112(1):122-30. doi: 10.1038/bjc.2014.560. Epub 2014 Nov 13.

PMID:
25393365
11.

Wild-type p53 inhibits pro-invasive properties of TGF-β3 in breast cancer, in part through regulation of EPHB2, a new TGF-β target gene.

Lam S, Wiercinska E, Teunisse AF, Lodder K, ten Dijke P, Jochemsen AG.

Breast Cancer Res Treat. 2014 Nov;148(1):7-18. doi: 10.1007/s10549-014-3147-8. Epub 2014 Sep 26.

PMID:
25257729
12.

Assessment of functional competence of endothelial cells from human pluripotent stem cells in zebrafish embryos.

Orlova VV, Drabsch Y, ten Dijke P, Mummery CL.

Methods Mol Biol. 2014;1213:107-19. doi: 10.1007/978-1-4939-1453-1_10.

PMID:
25173378
13.

Time-resolved dissection of early phosphoproteome and ensuing proteome changes in response to TGF-β.

D'Souza RC, Knittle AM, Nagaraj N, van Dinther M, Choudhary C, ten Dijke P, Mann M, Sharma K.

Sci Signal. 2014 Jul 22;7(335):rs5. doi: 10.1126/scisignal.2004856.

PMID:
25056879
14.

Generation, expansion and functional analysis of endothelial cells and pericytes derived from human pluripotent stem cells.

Orlova VV, van den Hil FE, Petrus-Reurer S, Drabsch Y, Ten Dijke P, Mummery CL.

Nat Protoc. 2014;9(6):1514-31. doi: 10.1038/nprot.2014.102. Epub 2014 May 29.

PMID:
24874816
15.

Loss of SMAD4 alters BMP signaling to promote colorectal cancer cell metastasis via activation of Rho and ROCK.

Voorneveld PW, Kodach LL, Jacobs RJ, Liv N, Zonnevylle AC, Hoogenboom JP, Biemond I, Verspaget HW, Hommes DW, de Rooij K, van Noesel CJ, Morreau H, van Wezel T, Offerhaus GJ, van den Brink GR, Peppelenbosch MP, Ten Dijke P, Hardwick JC.

Gastroenterology. 2014 Jul;147(1):196-208.e13. doi: 10.1053/j.gastro.2014.03.052. Epub 2014 Apr 3.

PMID:
24704720
16.

Targeting TGF-β Signaling by Antisense Oligonucleotide-mediated Knockdown of TGF-β Type I Receptor.

Kemaladewi DU, Pasteuning S, van der Meulen JW, van Heiningen SH, van Ommen GJ, Ten Dijke P, Aartsma-Rus A, 't Hoen PA, Hoogaars WM.

Mol Ther Nucleic Acids. 2014 Apr 1;3:e156. doi: 10.1038/mtna.2014.7.

17.

ENDOGLIN is dispensable for vasculogenesis, but required for vascular endothelial growth factor-induced angiogenesis.

Liu Z, Lebrin F, Maring JA, van den Driesche S, van der Brink S, van Dinther M, Thorikay M, Martin S, Kobayashi K, Hawinkels LJ, van Meeteren LA, Pardali E, Korving J, Letarte M, Arthur HM, Theuer C, Goumans MJ, Mummery C, ten Dijke P.

PLoS One. 2014 Jan 28;9(1):e86273. doi: 10.1371/journal.pone.0086273. eCollection 2014.

18.

Novel Ex Vivo Culture Method for the Study of Dupuytren's Disease: Effects of TGFβ Type 1 Receptor Modulation by Antisense Oligonucleotides.

Karkampouna S, Kruithof BP, Kloen P, Obdeijn MC, van der Laan AM, Tanke HJ, Kemaladewi DU, Hoogaars WM, 't Hoen PA, Aartsma-Rus A, Clark IM, Ten Dijke P, Goumans MJ, Kruithof-de Julio M.

Mol Ther Nucleic Acids. 2014 Jan 21;3:e142. doi: 10.1038/mtna.2013.69.

19.

Mutational analysis of sclerostin shows importance of the flexible loop and the cystine-knot for Wnt-signaling inhibition.

Boschert V, van Dinther M, Weidauer S, van Pee K, Muth EM, Ten Dijke P, Mueller TD.

PLoS One. 2013 Nov 29;8(11):e81710. doi: 10.1371/journal.pone.0081710. eCollection 2013. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/067f1197-3290-4d1e-8f77-4d3996a6b9e8.

20.

Signaling interplay between transforming growth factor-β receptor and PI3K/AKT pathways in cancer.

Zhang L, Zhou F, ten Dijke P.

Trends Biochem Sci. 2013 Dec;38(12):612-20. doi: 10.1016/j.tibs.2013.10.001. Epub 2013 Nov 14. Review.

PMID:
24239264
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