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Results: 1 to 20 of 293

1.

Time-resolved dissection of early phosphoproteome and ensuing proteome changes in response to TGF-β.

J D'Souza RC, Knittle AM, Nagaraj N, van Dinther M, Choudhary C, Ten Dijke P, Mann M, Sharma K.

Sci Signal. 2014 Jul 22;7(335):rs5. doi: 10.1126/scisignal.2004856.

PMID:
25056879
[PubMed - in process]
2.

Generation, expansion and functional analysis of endothelial cells and pericytes derived from human pluripotent stem cells.

Orlova VV, van den Hil FE, Petrus-Reurer S, Drabsch Y, Ten Dijke P, Mummery CL.

Nat Protoc. 2014 Jun;9(6):1514-31. doi: 10.1038/nprot.2014.102. Epub 2014 May 29.

PMID:
24874816
[PubMed - in process]
3.

Loss of SMAD4 alters BMP signaling to promote colorectal cancer cell metastasis via activation of Rho and ROCK.

Voorneveld PW, Kodach LL, Jacobs RJ, Liv N, Zonnevylle AC, Hoogenboom JP, Biemond I, Verspaget HW, Hommes DW, de Rooij K, van Noesel CJ, Morreau H, van Wezel T, Offerhaus GJ, van den Brink GR, Peppelenbosch MP, Ten Dijke P, Hardwick JC.

Gastroenterology. 2014 Jul;147(1):196-208.e13. doi: 10.1053/j.gastro.2014.03.052. Epub 2014 Apr 3.

PMID:
24704720
[PubMed - in process]
4.

Targeting TGF-β Signaling by Antisense Oligonucleotide-mediated Knockdown of TGF-β Type I Receptor.

Kemaladewi DU, Pasteuning S, van der Meulen JW, van Heiningen SH, van Ommen GJ, Ten Dijke P, Aartsma-Rus A, 't Hoen PA, Hoogaars WM.

Mol Ther Nucleic Acids. 2014 Apr 1;3:e156. doi: 10.1038/mtna.2014.7.

PMID:
24691207
[PubMed]
Free PMC Article
5.

ENDOGLIN is dispensable for vasculogenesis, but required for vascular endothelial growth factor-induced angiogenesis.

Liu Z, Lebrin F, Maring JA, van den Driesche S, van der Brink S, van Dinther M, Thorikay M, Martin S, Kobayashi K, Hawinkels LJ, van Meeteren LA, Pardali E, Korving J, Letarte M, Arthur HM, Theuer C, Goumans MJ, Mummery C, ten Dijke P.

PLoS One. 2014 Jan 28;9(1):e86273. doi: 10.1371/journal.pone.0086273. eCollection 2014.

PMID:
24489709
[PubMed - in process]
Free PMC Article
6.

Novel Ex Vivo Culture Method for the Study of Dupuytren's Disease: Effects of TGFβ Type 1 Receptor Modulation by Antisense Oligonucleotides.

Karkampouna S, Kruithof BP, Kloen P, Obdeijn MC, van der Laan AM, Tanke HJ, Kemaladewi DU, Hoogaars WM, 't Hoen PA, Aartsma-Rus A, Clark IM, Ten Dijke P, Goumans MJ, Kruithof-de Julio M.

Mol Ther Nucleic Acids. 2014 Jan 21;3:e142. doi: 10.1038/mtna.2013.69.

PMID:
24448195
[PubMed]
Free PMC Article
7.

Mutational analysis of sclerostin shows importance of the flexible loop and the cystine-knot for Wnt-signaling inhibition.

Boschert V, van Dinther M, Weidauer S, van Pee K, Muth EM, Ten Dijke P, Mueller TD.

PLoS One. 2013 Nov 29;8(11):e81710. doi: 10.1371/journal.pone.0081710. eCollection 2013.

PMID:
24312339
[PubMed - in process]
Free PMC Article
8.

Signaling interplay between transforming growth factor-β receptor and PI3K/AKT pathways in cancer.

Zhang L, Zhou F, ten Dijke P.

Trends Biochem Sci. 2013 Dec;38(12):612-20. doi: 10.1016/j.tibs.2013.10.001. Epub 2013 Nov 14. Review.

PMID:
24239264
[PubMed - indexed for MEDLINE]
9.

Transforming growth factor-β signalling controls human breast cancer metastasis in a zebrafish xenograft model.

Drabsch Y, He S, Zhang L, Snaar-Jagalska BE, ten Dijke P.

Breast Cancer Res. 2013 Nov 7;15(6):R106. doi: 10.1186/bcr3573.

PMID:
24196484
[PubMed - in process]
Free PMC Article
10.

Activin receptor-like kinase 1 as a target for anti-angiogenesis therapy.

Hawinkels LJ, Garcia de Vinuesa A, Ten Dijke P.

Expert Opin Investig Drugs. 2013 Nov;22(11):1371-83. doi: 10.1517/13543784.2013.837884. Epub 2013 Sep 21. Review. Erratum in: Expert Opin Investig Drugs. 2013 Dec;22(12):1695.

PMID:
24053899
[PubMed - indexed for MEDLINE]
11.

Transforming growth factor-β (TGF-β)-mediated connective tissue growth factor (CTGF) expression in hepatic stellate cells requires Stat3 signaling activation.

Liu Y, Liu H, Meyer C, Li J, Nadalin S, Königsrainer A, Weng H, Dooley S, ten Dijke P.

J Biol Chem. 2013 Oct 18;288(42):30708-19. doi: 10.1074/jbc.M113.478685. Epub 2013 Sep 4.

PMID:
24005672
[PubMed - indexed for MEDLINE]
12.

TRAF4 promotes TGF-β receptor signaling and drives breast cancer metastasis.

Zhang L, Zhou F, García de Vinuesa A, de Kruijf EM, Mesker WE, Hui L, Drabsch Y, Li Y, Bauer A, Rousseau A, Sheppard KA, Mickanin C, Kuppen PJ, Lu CX, Ten Dijke P.

Mol Cell. 2013 Sep 12;51(5):559-72. doi: 10.1016/j.molcel.2013.07.014. Epub 2013 Aug 22.

PMID:
23973329
[PubMed - indexed for MEDLINE]
13.

FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension.

Spiekerkoetter E, Tian X, Cai J, Hopper RK, Sudheendra D, Li CG, El-Bizri N, Sawada H, Haghighat R, Chan R, Haghighat L, de Jesus Perez V, Wang L, Reddy S, Zhao M, Bernstein D, Solow-Cordero DE, Beachy PA, Wandless TJ, Ten Dijke P, Rabinovitch M.

J Clin Invest. 2013 Aug 1;123(8):3600-13. doi: 10.1172/JCI65592. Epub 2013 Jul 15.

PMID:
23867624
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Antisense-oligonucleotide mediated exon skipping in activin-receptor-like kinase 2: inhibiting the receptor that is overactive in fibrodysplasia ossificans progressiva.

Shi S, Cai J, de Gorter DJ, Sanchez-Duffhues G, Kemaladewi DU, Hoogaars WM, Aartsma-Rus A, 't Hoen PA, ten Dijke P.

PLoS One. 2013 Jul 4;8(7):e69096. doi: 10.1371/journal.pone.0069096. Print 2013.

PMID:
23861958
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Three-dimensional co-cultures of human endothelial cells and embryonic stem cell-derived pericytes inside a microfluidic device.

van der Meer AD, Orlova VV, ten Dijke P, van den Berg A, Mummery CL.

Lab Chip. 2013 Sep 21;13(18):3562-8. doi: 10.1039/c3lc50435b.

PMID:
23702711
[PubMed - indexed for MEDLINE]
16.

Anti-Sclerostin antibody inhibits internalization of Sclerostin and Sclerostin-mediated antagonism of Wnt/LRP6 signaling.

van Dinther M, Zhang J, Weidauer SE, Boschert V, Muth EM, Knappik A, de Gorter DJ, van Kasteren PB, Frisch C, Mueller TD, ten Dijke P.

PLoS One. 2013 Apr 29;8(4):e62295. doi: 10.1371/journal.pone.0062295. Print 2013.

PMID:
23638027
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Snail and Slug, key regulators of TGF-β-induced EMT, are sufficient for the induction of single-cell invasion.

Naber HP, Drabsch Y, Snaar-Jagalska BE, ten Dijke P, van Laar T.

Biochem Biophys Res Commun. 2013 May 24;435(1):58-63. doi: 10.1016/j.bbrc.2013.04.037. Epub 2013 Apr 22.

PMID:
23618854
[PubMed - indexed for MEDLINE]
18.

Preventive and therapeutic effects of Smad7 on radiation-induced oral mucositis.

Han G, Bian L, Li F, Cotrim A, Wang D, Lu J, Deng Y, Bird G, Sowers A, Mitchell JB, Gutkind JS, Zhao R, Raben D, ten Dijke P, Refaeli Y, Zhang Q, Wang XJ.

Nat Med. 2013 Apr;19(4):421-8. doi: 10.1038/nm.3118. Epub 2013 Mar 10.

PMID:
23475202
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6.

Zhang X, Zhang J, Bauer A, Zhang L, Selinger DW, Lu CX, Ten Dijke P.

EMBO J. 2013 Apr 3;32(7):996-1007. doi: 10.1038/emboj.2013.38. Epub 2013 Mar 1.

PMID:
23455153
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination.

Anderberg C, Cunha SI, Zhai Z, Cortez E, Pardali E, Johnson JR, Franco M, Páez-Ribes M, Cordiner R, Fuxe J, Johansson BR, Goumans MJ, Casanovas O, ten Dijke P, Arthur HM, Pietras K.

J Exp Med. 2013 Mar 11;210(3):563-79. doi: 10.1084/jem.20120662. Epub 2013 Feb 11.

PMID:
23401487
[PubMed - indexed for MEDLINE]
Free PMC Article

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