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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1918 1
1920 1
1930 1
1932 1
1945 2
1946 1
1947 2
1948 3
1949 2
1950 1
1951 2
1952 1
1953 1
1954 1
1955 1
1956 1
1957 1
1958 1
1959 2
1960 2
1961 2
1962 2
1963 9
1964 8
1965 4
1966 5
1967 12
1968 5
1969 6
1970 8
1971 13
1972 10
1973 12
1974 12
1975 12
1976 13
1977 25
1978 15
1979 8
1980 12
1981 10
1982 8
1983 15
1984 22
1985 19
1986 18
1987 27
1988 13
1989 20
1990 28
1991 37
1992 23
1993 30
1994 18
1995 24
1996 40
1997 32
1998 33
1999 35
2000 65
2001 86
2002 65
2003 102
2004 100
2005 154
2006 159
2007 182
2008 162
2009 219
2010 236
2011 207
2012 236
2013 220
2014 254
2015 264
2016 246
2017 197
2018 230
2019 231
2020 236
2021 276
2022 252
2023 274
2024 103

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5,081 results

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Page 1
Importance of tautomerism in drugs.
Bharatam PV, Valanju OR, Wani AA, Dhaked DK. Bharatam PV, et al. Drug Discov Today. 2023 Apr;28(4):103494. doi: 10.1016/j.drudis.2023.103494. Epub 2023 Jan 18. Drug Discov Today. 2023. PMID: 36681235 Review.
Nuclear magnetic resonance (NMR), infrared (IR), ultraviolet (UV), Raman, and terahertz spectroscopic techniques, as well as X-ray diffraction, are useful for exploring drug tautomerism. Quantum chemical methods, in association with pharmacoinformatics tools, are being use …
Nuclear magnetic resonance (NMR), infrared (IR), ultraviolet (UV), Raman, and terahertz spectroscopic techniques, as well as X-ray diffracti …
Spectroscopy and Tautomerization Studies of Porphycenes.
Waluk J. Waluk J. Chem Rev. 2017 Feb 22;117(4):2447-2480. doi: 10.1021/acs.chemrev.6b00328. Epub 2016 Jul 28. Chem Rev. 2017. PMID: 27468110 Review.
Tautomerization in porphycenes, constitutional isomers of porphyrins, is strongly entangled with spectral and photophysical parameters. ...Next, photophysical characteristics are presented, setting the stage for the final part, which discusses the developments in research …
Tautomerization in porphycenes, constitutional isomers of porphyrins, is strongly entangled with spectral and photophysical parameter …
Importance of Indazole against Neurological Disorders.
Pal D, Sahu P. Pal D, et al. Curr Top Med Chem. 2022;22(14):1136-1151. doi: 10.2174/1568026622666220225152443. Curr Top Med Chem. 2022. PMID: 35232360 Review.
Indazole is a nitrogen-containing bicyclic compound, having three tautomeric forms: 1Hindazole, 2H-indazole, and 3H-indazole. Mostly, they are considered as 1H-indazole tautomeric forms, although they have the potential to tautomerism to 2H- and 3H-indazole f …
Indazole is a nitrogen-containing bicyclic compound, having three tautomeric forms: 1Hindazole, 2H-indazole, and 3H-indazole. Mostly, …
NMR of Natural Products as Potential Drugs.
Hansen PE. Hansen PE. Molecules. 2021 Jun 21;26(12):3763. doi: 10.3390/molecules26123763. Molecules. 2021. PMID: 34205539 Free PMC article. Review.
This review outlines methods to investigate the structure of natural products with emphasis on intramolecular hydrogen bonding, tautomerism and ionic structures using NMR techniques. The focus is on 1H chemical shifts, isotope effects on chemical shifts and diffusion order …
This review outlines methods to investigate the structure of natural products with emphasis on intramolecular hydrogen bonding, tautomeri …
Role of tautomerism in RNA biochemistry.
Singh V, Fedeles BI, Essigmann JM. Singh V, et al. RNA. 2015 Jan;21(1):1-13. doi: 10.1261/rna.048371.114. RNA. 2015. PMID: 25516996 Free PMC article. Review.
Heterocyclic nucleic acid bases and their analogs can adopt multiple tautomeric forms due to the presence of multiple solvent-exchangeable protons. ...This review summarizes the role of tautomerism in RNA biochemistry, specifically focusing on the role of tautome …
Heterocyclic nucleic acid bases and their analogs can adopt multiple tautomeric forms due to the presence of multiple solvent-exchang …
Structural Studies of β-Diketones and Their Implications on Biological Effects.
Hansen PE. Hansen PE. Pharmaceuticals (Basel). 2021 Nov 20;14(11):1189. doi: 10.3390/ph14111189. Pharmaceuticals (Basel). 2021. PMID: 34832971 Free PMC article. Review.
Density functional calculations are also briefly treated. Emphasis is on the tautomeric equilibria of beta-diketones in relation to biological effects. ...A series of biologically active molecules are treated with respect to structure (tautomerism). Characteristic m …
Density functional calculations are also briefly treated. Emphasis is on the tautomeric equilibria of beta-diketones in relation to b …
Warfarin: history, tautomerism and activity.
Porter WR. Porter WR. J Comput Aided Mol Des. 2010 Jun;24(6-7):553-73. doi: 10.1007/s10822-010-9335-7. Epub 2010 Mar 30. J Comput Aided Mol Des. 2010. PMID: 20352297 Review.
The history of studies on warfarin tautomerism is reviewed, along with the implications of tautomerism to its biological properties (activity, protein binding and metabolism) and chemical properties (log P, log D, pK (a)). Experimental approaches to assessing warfar …
The history of studies on warfarin tautomerism is reviewed, along with the implications of tautomerism to its biological prope …
Time delay during intra-base proton tunneling in the guanine base of the single stranded DNA.
Özçelik E, Akar DE, Zaman S, Demir D. Özçelik E, et al. Prog Biophys Mol Biol. 2022 Sep;173:4-10. doi: 10.1016/j.pbiomolbio.2022.05.009. Epub 2022 Jun 1. Prog Biophys Mol Biol. 2022. PMID: 35659504 Review.
Spontaneous point mutations are one of the main actors in evolution, and the tautomerization of organic bases in the DNA is hypothesized to be the underlying mechanism of this crucial process. Tautomerization can be induced by proton tunneling, and if it occurs in s …
Spontaneous point mutations are one of the main actors in evolution, and the tautomerization of organic bases in the DNA is hypothesi …
Experimental and pK(a) prediction aspects of tautomerism of drug-like molecules.
Martin YC. Martin YC. Drug Discov Today Technol. 2018 Jul;27:59-64. doi: 10.1016/j.ddtec.2018.06.006. Epub 2018 Jun 27. Drug Discov Today Technol. 2018. PMID: 30103864 Review.
Molecules that can tautomerize are a challenge to scientists because one must consider the possible tautomers in most tasks involving chemical structures: for example, searching databases, interpreting experimental property measurements, calculating properties, virtual scr …
Molecules that can tautomerize are a challenge to scientists because one must consider the possible tautomers in most tasks involving …
Excited-State Intramolecular Proton Transfer: A Short Introductory Review.
Joshi HC, Antonov L. Joshi HC, et al. Molecules. 2021 Mar 9;26(5):1475. doi: 10.3390/molecules26051475. Molecules. 2021. PMID: 33803102 Free PMC article. Review.
Since Weller's discovery of ESIPT in salicylic acid (SA) and its derivative methyl salicylate (MS), numerous studies have emerged on the topic and it has become an attractive field of research because of its manifold applications. Here, we discuss some critical aspects of ESIPT a …
Since Weller's discovery of ESIPT in salicylic acid (SA) and its derivative methyl salicylate (MS), numerous studies have emerged on the top …
5,081 results