Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 1
2004 1
2005 1
2006 1
2007 2
2008 7
2009 8
2010 11
2011 10
2012 13
2013 14
2014 21
2015 23
2016 23
2017 23
2018 27
2019 43
2020 40
2021 37
2022 31
2023 42
2024 19

Text availability

Article attribute

Article type

Publication date

Search Results

345 results

Results by year

Citations

1 article found by citation matching

Search results

Filters applied: . Clear all
Page 1
Did you mean targeting ampk more cardiac protection (19 results)?
Targeting AMPK for cardiac protection: opportunities and challenges.
Kim M, Tian R. Kim M, et al. J Mol Cell Cardiol. 2011 Oct;51(4):548-53. doi: 10.1016/j.yjmcc.2010.12.004. Epub 2010 Dec 13. J Mol Cell Cardiol. 2011. PMID: 21147121 Free PMC article. Review.
AMP-activated protein kinase (AMPK) regulates cellular energy homeostasis and multiple biological processes in cell growth and survival, hence an attractive drug target. AMPK is a heterotrimeric protein consisting of alpha catalyti …
AMP-activated protein kinase (AMPK) regulates cellular energy homeostasis and multiple biological processes in c …
FGF21-Sirtuin 3 Axis Confers the Protective Effects of Exercise Against Diabetic Cardiomyopathy by Governing Mitochondrial Integrity.
Jin L, Geng L, Ying L, Shu L, Ye K, Yang R, Liu Y, Wang Y, Cai Y, Jiang X, Wang Q, Yan X, Liao B, Liu J, Duan F, Sweeney G, Woo CWH, Wang Y, Xia Z, Lian Q, Xu A. Jin L, et al. Circulation. 2022 Nov 15;146(20):1537-1557. doi: 10.1161/CIRCULATIONAHA.122.059631. Epub 2022 Sep 22. Circulation. 2022. PMID: 36134579
RESULTS: Treadmill exercise markedly induced cardiac expression of beta-klotho and significantly attenuated diabetes-induced cardiac dysfunction in wild-type mice, accompanied by reduced mitochondrial damage and increased activities of mitochondrial enzymes in heart …
RESULTS: Treadmill exercise markedly induced cardiac expression of beta-klotho and significantly attenuated diabetes-induced cardi …
Molecular machinery and interplay of apoptosis and autophagy in coronary heart disease.
Dong Y, Chen H, Gao J, Liu Y, Li J, Wang J. Dong Y, et al. J Mol Cell Cardiol. 2019 Nov;136:27-41. doi: 10.1016/j.yjmcc.2019.09.001. Epub 2019 Sep 7. J Mol Cell Cardiol. 2019. PMID: 31505198 Free article. Review.
Coronary heart disease (CHD) is a common heart disease and the leading cause of cardiovascular death. ...In contrast, activated autophagy protects heart from myocardial ischemia injury and post-ischemia cardiac remodeling, but can exert controve …
Coronary heart disease (CHD) is a common heart disease and the leading cause of cardiovascular death. ...In contrast, activate …
Resveratrol and Cardiovascular Diseases.
Bonnefont-Rousselot D. Bonnefont-Rousselot D. Nutrients. 2016 May 2;8(5):250. doi: 10.3390/nu8050250. Nutrients. 2016. PMID: 27144581 Free PMC article. Review.
Preclinical studies have made it possible to identify molecular targets (SIRT-1, AMPK, Nrf2, NFkappaB); however, there are limited human clinical trials, and difficulties in the interpretation of results arise from the use of high-dose RES supplements in research st …
Preclinical studies have made it possible to identify molecular targets (SIRT-1, AMPK, Nrf2, NFkappaB); however, there are lim …
Cardiac metabolism as a driver and therapeutic target of myocardial infarction.
Zuurbier CJ, Bertrand L, Beauloye CR, Andreadou I, Ruiz-Meana M, Jespersen NR, Kula-Alwar D, Prag HA, Eric Botker H, Dambrova M, Montessuit C, Kaambre T, Liepinsh E, Brookes PS, Krieg T. Zuurbier CJ, et al. J Cell Mol Med. 2020 Jun;24(11):5937-5954. doi: 10.1111/jcmm.15180. Epub 2020 May 8. J Cell Mol Med. 2020. PMID: 32384583 Free PMC article. Review.
Reducing infarct size during a cardiac ischaemic-reperfusion episode is still of paramount importance, because the extension of myocardial necrosis is an important risk factor for developing heart failure. ...Currently, the most promising and druggable metabolic the …
Reducing infarct size during a cardiac ischaemic-reperfusion episode is still of paramount importance, because the extension of myoca …
Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species.
Zhang XJ, Liu X, Hu M, Zhao GJ, Sun D, Cheng X, Xiang H, Huang YP, Tian RF, Shen LJ, Ma JP, Wang HP, Tian S, Gan S, Xu H, Liao R, Zou T, Ji YX, Zhang P, Cai J, Wang ZV, Meng G, Xu Q, Wang Y, Ma XL, Liu PP, Huang Z, Zhu L, She ZG, Zhang X, Bai L, Yang H, Lu Z, Li H. Zhang XJ, et al. Cell Metab. 2021 Oct 5;33(10):2059-2075.e10. doi: 10.1016/j.cmet.2021.08.014. Epub 2021 Sep 17. Cell Metab. 2021. PMID: 34536344 Free article.
Remarkably, pharmacological inhibition of ALOX12 significantly reduced cardiac injury in mice, pigs, and monkeys. Unexpectedly, ALOX12 promotes cardiomyocyte injury beyond its enzymatic activity and production of 12-HETE but also by its suppression of AMPK activity …
Remarkably, pharmacological inhibition of ALOX12 significantly reduced cardiac injury in mice, pigs, and monkeys. Unexpectedly, ALOX1 …
Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS/STING signaling dependent on LKB1/AMPK/ULK1-mediated autophagy.
Lu QB, Ding Y, Liu Y, Wang ZC, Wu YJ, Niu KM, Li KX, Zhang JR, Sun HJ. Lu QB, et al. J Adv Res. 2023 Sep;51:161-179. doi: 10.1016/j.jare.2022.10.014. Epub 2022 Nov 9. J Adv Res. 2023. PMID: 36334887 Free PMC article.
Metrnl is found to protect against cardiac hypertrophy and doxorubicin-induced cardiotoxicity. ...Cardiac-specific overexpression (OE) of Metrnl markedly ameliorated cardiac injury and dysfunction in both T1D and T2D mice. ...
Metrnl is found to protect against cardiac hypertrophy and doxorubicin-induced cardiotoxicity. ...Cardiac-specific over …
Autophagy in the diabetic heart: A potential pharmacotherapeutic target in diabetic cardiomyopathy.
Dewanjee S, Vallamkondu J, Kalra RS, John A, Reddy PH, Kandimalla R. Dewanjee S, et al. Ageing Res Rev. 2021 Jul;68:101338. doi: 10.1016/j.arr.2021.101338. Epub 2021 Apr 7. Ageing Res Rev. 2021. PMID: 33838320 Review.
Although autophagy plays a vital role in maintaining the cellular homeostasis in diligent cardiac tissues, this process is frequently impaired in the diabetic heart. ...Given the clinical significance of autophagy in the diabetic heart, we further discussed t …
Although autophagy plays a vital role in maintaining the cellular homeostasis in diligent cardiac tissues, this process is frequently …
Salidroside inhibits doxorubicin-induced cardiomyopathy by modulating a ferroptosis-dependent pathway.
Chen H, Zhu J, Le Y, Pan J, Liu Y, Liu Z, Wang C, Dou X, Lu D. Chen H, et al. Phytomedicine. 2022 May;99:153964. doi: 10.1016/j.phymed.2022.153964. Epub 2022 Jan 29. Phytomedicine. 2022. PMID: 35180677
Mechanistically, salidroside inhibited DOX-induced mitochondrial ROS, Fe(2+), and lipid peroxidation as well as restored mitochondrial membrane potential by promoting mitochondrial biogenesis, improving mitochondrial iron-sulfur clusters, and restoring mitochondrial OXPHOS comple …
Mechanistically, salidroside inhibited DOX-induced mitochondrial ROS, Fe(2+), and lipid peroxidation as well as restored mitochondrial membr …
SIRT2 Acts as a Cardioprotective Deacetylase in Pathological Cardiac Hypertrophy.
Tang X, Chen XF, Wang NY, Wang XM, Liang ST, Zheng W, Lu YB, Zhao X, Hao DL, Zhang ZQ, Zou MH, Liu DP, Chen HZ. Tang X, et al. Circulation. 2017 Nov 21;136(21):2051-2067. doi: 10.1161/CIRCULATIONAHA.117.028728. Epub 2017 Sep 25. Circulation. 2017. PMID: 28947430 Free PMC article.
BACKGROUND: Pathological cardiac hypertrophy induced by stresses such as aging and neurohumoral activation is an independent risk factor for heart failure and is considered a target for the treatment of heart failure. ...Mechanistically, SIRT2 maintain …
BACKGROUND: Pathological cardiac hypertrophy induced by stresses such as aging and neurohumoral activation is an independent risk fac …
345 results